Biomedical subjects
Publications and source records attributed to J Weinreich.
During a period of two months, 37 patients with permanent indwelling bladder catheters on account of incontinence of urine/retention were requested to register the inconveniences connected with the treatment. Despite the necessity of catheter changes more frequently than originally planned, urinary infection and altered sexual behaviour, the majority of patients expressed satisfaction with catheter life.
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The correlation between the haustral pattern in the sigmoid colon, on the one hand, and the pressure activity and presence of diverticula, on the other, was examined in 184 patients, subjected to both X-ray examination and sigmoid pressure measurement. No correlation was found between an increased haustral pattern and a high pressure activity. Only a special S-shaped haustral pattern showed a slight correlation to an increased pressure activity. An interpretation of colonic haustral pattern in terms of muscular activity, therefore, seems unwarranted. A significant correlation was found between an increased haustral pattern and the presence of sigmoid diverticula.
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A modified method for measurement of pressure activity in the sigmoid colon is presented, using open-ended tubes and measurement of pressure activity for 30 minutes after intravenous administration of 0.5 mg of neostigmine. The motility index in 12 normal persons was found to have median 597 with a range of 125-1169. Variation among persons exceeded the day-to-day variation significantly. Error in reading the curves was negligible.
Patients with lower abdominal symptoms, indicating colonic disorder, were classified into predefined clinical syndromes. Two important syndromes were colicky sigmoid syndrome and chronic diverticular disease. The first one, characterized by presence of colicky lower abdominal pains but absence of colonic diverticula, probably covers what is generally referred to as 'irritable bowel syndrome'. The second one was characterized by presence of lower abdominal colics and of colonic diverticula. The results showed a significant correlation between the presence of lower abdominal colics and a high pressure activity in the sigmoid colon after intravenous neostigmine. There was, however, no correlation between the presence of diverticula and a high pressure activity. The generally accepted theory of a high pressure activity as the dominant factor in the pathogenesis of colonic diverticula, therefore, was questioned, as was the equally accepted theory of a gradual development of chronic diverticular disease from the adiverticular colicky sigmoid syndrome.
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