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Biomedical subjects

J Weiskopf

Publications and source records attributed to J Weiskopf.

17 recordsLinked to original sources
PubMed1985

Amphotericin clearance in vitrectomized versus nonvitrectomized eyes.

Ocular clearance of amphotericin B after direct intravitreal injection was studied in a rabbit model. Unmodified phakic eyes, Candida-infected eyes, aphakic eyes, and aphakic vitrectomized eyes were employed. Using high pressure liquid chromatography to assess drug level, the half-lives of drug disappearance after single 10-microgram (microgram) intravitreal injections were 9.1, 8.6, 4.7, and 1.4 days, respectively. The disappearance slope for vitrectomized eyes was significantly different from all nonvitrectomized eyes with P less than 0.001. The rapid disappearance of amphotericin from vitrectomized eyes must be considered in clinical management of patients with fungal endophthalmitis.

Amphotericin B↗
PubMed1979

[Mandibular positioning and movements relative to the pain dysfunction syndrome].

The movements and positions of the mandible are controlled by three guiding factors: tooth guidance, joint guidance, and muscle guidance. For this reason, the author proposes new, clearly delineated definitions for the terms "central occlusion", "central relation" and "muscle guidance". The unity of structure and function results from the harmony (biological equilibrium) between these three guiding factors. Deviations of the individual guiding factors (occlusal disorders, decentralized relations, malpositions and misguidances of the muscles) may be analyzed separately to begin with; thereupon, their interrelations will be elucidated. As not all of these three guiding factors are necessarily involved in an impairment (above all, the mandibular joints often show no abnormalities), and since pain is the principle sign in the clinical picture of a dysfunction of the orofacial organ, the author is of the opinion that the term "pain-dysfunction syndrome" (as coined by L. Schwarz) is more correct than such terms as "Costen's syndrome" or "myoarthropathy".

Dental Occlusion, Centric↗
PubMed1977

[Achieving therapeutic success with cast removable partial dentures].

The strategic goal is the complex prosthetic rehabilitation for a period of at least 10 years. Thorough oral examination is the basis of differential indication and treatment planning. The pretreatment is an integral part of the therapy. The construction must take into consideration the following facts. The periodontal support is in general superior to the gingival supprt (dependence on incomplete dentition). Primary splinting is in general superior to secondary splinting. The denture skeleton must be stable. The prosthesis should be constructed in such a manner that it can be extended, adjusted and rebased. The denture skeleton and the connectors should not cover the marginal gingiva. Denture sore is caused by mechanical irritation and infection. Mouth and prosthesis hygiene is of prime importance also from the viewpoint of caries prevention and periodontal prophylaxis.

Denture Bases↗