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Biomedical subjects

J Weisman

Publications and source records attributed to J Weisman.

14 recordsLinked to original sources
PubMed1995

Mood recognition across the ages.

A cross-sectional study was conducted in which level of mood recognition was assessed from early childhood through old age. Asymptotic performance was obtained on facial affect recognitions tasks from ages 3-34 yrs. There was a progressive decline in facial affect recognitions beginning at age 45, with the principal problem that of recognizing angry faces. With respect to auditory prosody, there was an improvement in recognition level from ages 3-12 yrs. Performance remained asymptotic through age 43 and then began to decline increasingly beyond age 45.

Adolescent↗
PubMed1994

Facial affect recognition in singly diagnosed mentally retarded people and normal young children: a methodological comparison.

Facial affect recognition was studied in groups of mildly retarded subjects, moderately retarded subjects, and nonretarded children. Subjects were tested under five conditions. In Condition 1, they were presented with happy, sad and angry faces simultaneously in each of 18 trials and were prompted with short commands to point to one of the affective faces. Conditions 2 and 3 were the same as the first, except that subjects were prompted with short affective vignettes. In Condition 2, the vignettes were followed by tag lines identifying the moods of the vignettes. There were no tag lines in Condition 3. Conditions 4 and 5 were identical to Conditions 2 and 3, except that the vignettes were longer. The error data were analyzed and results showed that the groups did not differ in response to short commands and vignette prompts produced more errors than short commands. Also, long vignettes gave rise to more mistakes than short vignettes, and vignettes without tag lines resulted in more errors than those with tag lines. Group differences emerged when vignettes were presented, with more errors made as level of retardation and length of vignettes increased. It was concluded that mental retardation is not associated with a disturbance in facial affect recognition.

Adult↗
PubMed1992

Neuroretinitis: an unusual presentation of ocular toxoplasmosis.

Neuroretinitis is a clinical condition usually seen in young healthy adults that is characterized by rapid profound unilateral loss of vision. Funduscopic findings include swollen disc, splinter hemorrhages, and macular star. Catscratch fever and leptospirosis have been suggested as possible etiologies in this condition. We report a case of a patient with neuroretinitis whose only laboratory abnormality was an elevated enzyme-linked immunosorbent assay immunoglobulin G Toxoplasma titer. The patient responded favorably to treatment with clindamycin, triple sulfa, and systemic corticosteroids. We recommended toxoplasmic serology be added to the workup of patients with neuroretinitis.

Adult↗
PubMed1991

Comparing three head-pointing systems using a single subject design.

The keyboard is the most commonly used input method for interfacing with computers. When using a keyboard is not possible, alternative computer input methods are needed. Three methods using head control are: Head Master by Prentke Romich, Free Wheel by Pointer Systems, and LROP by Words+. The purpose of this study was to compare these three methods for speed and accuracy using a single subject design for nine individuals with disabilities. Visual inspection of the data revealed that subjects obtained higher scores when using Head Master and LROP than Free Wheel. As a follow-up test, an analysis of variance test for repeated measures showed no difference between using Head Master and LROP but did show a significant difference between Head Master and Free Wheel, and LROP and Free Wheel.

Adult↗
PubMed1977

Exudative retinal detachment secondary to dislocated lenses.

2 cases of retinal detachment with ectopia lentis are described. In each, the retinal elevations had surface features consistent with exudative detachments. Following removal of the posteriorly displaced lenses spontaneous retinal attachment was noted. The clinical and surgical course of these patients suggest a diagnosis of lens-induced exudative retinal detachment.

Adult↗
PubMedDate not supplied

Nonhypercalcemic analogs of vitamin D stimulate creatine kinase B activity in osteoblast-like ROS 17/2.8 cells and up-regulate their responsiveness to estrogens.

We have reported that pretreatment with 1 alpha, 25(OH)2D3(1, 25) up-regulates responsiveness and sensitivity to 17 beta estradiol (E2) in osteoblast-like cells, as measured by parallel stimulation of [3H]thymidine incorporation into DNA and the specific activity of creatine kinase BB (CK). Increased responsiveness was correlated with increased E2 receptor concentration. In this study, we have extended these observations to new nonhypercalcemic analogs of 1,25. We compared the analogs hexafluoro vitamin D3 (FL), and the side chain modified derivatives: EB 1089 (EB), CB 1093 (CB) and MC 1288 (MC) with 1,25 and 25 (OH)D3(25 D3). Treatment with 30 nM E2 for 4 h stimulated CK activity in ROS 17/2-8 cells by 40%; there was no further increase after 3 daily additions of E2. Treatment by 3 daily additions, at 1 nM, of all analogs except 25 D3 caused a 2-3-fold increase in CK specific activity. This schedule of treatment also upregulated the response to 4 h exposure to 30 nM E2 by 30-70% above the response to vitamin D analogs alone, and by up to 2 fold compared to E2 without pretreatment. At 1 pM, the analogs doubled CK activity, and, except for 1,25, upregulated the response to E2 to levels characteristic of each analog. Pretreatment with vitamin D analogs also increased the sensitivity to E2 by lowering the dose for a comparable response to E2 by one or two orders of magnitude. Stimulation of specific activity of CK by the analogs was paralleled by increases in the steady state level of mRNA for CKB, but not in its half life. Whereas pretreatment by vehicle followed by E2 for 2 h was unable to increase CKB mRNA, pretreatment with the analogs made possible detection of mRNA responsiveness to E2. These results add to the evidence for the interaction of estrogens and antiestrogens with vitamin D metabolites in regulation of bone growth in vitro. They also strengthen the potential for treatment of bone loss, as occurs in postmenopausal osteoporosis, by a combination of nonhypercalcemic vitamin D analogs and estrogens.

Animals↗
PubMedDate not supplied

Virus-neutralization versus agar-gel precipitin tests for detecting serological response to infectious bursal disease virus.

The virus-neutralization (VN) test was found much more sensitive than the agar-gel precipitin (AGP) test for detecting prior exposure to infectious bursal disease (IBD). Many sera that were negative in the AGP test were found to have VN antibodies, and virtually all sera in a commercial flock were free of precipitin but had VN titers. VN titers varied widely on a flock basis, and revaccination of an 8-month-old flock through the drinking water did not alter the antibody titers. Inoculation of maternally immune chicks at 7 days of age with IBD virus resulted in a good serologic response by both the AGP and VN tests.

Age Factors↗
PubMedDate not supplied

Infectious bursal disease virus infection attempts in turkeys and Coturnix quail.

Attempts failed to infect Coturnix quail with infectious bursal disease (IBD) virus by exposure at 7, 14, 21, and 31 days old. There were no clinical signs or gross and microscopic changes in the bursa of Fabricius, and serologic tests and virus isolation attempts from cloacal swabs were negative. Turkeys of two breeds exposed to IBD virus at 6 or 8 weeks old showed no clinical signs or lesions in the bursa of Fabricius, and the virus could not be isolated from cloacal swabs. They did respond serologically, however, by developing both precipitin and virus-neutralizing antibodies.

Animals↗
PubMedDate not supplied

Isolation of Yersinia (Pasteurella) pseudotuberculosis from the Palm dove (Streptopelia senegalensis).

Yersinia pseudotuberculosis was isolated from a sick Palm dove (Streptopelia senegalensis) picked up near a turkey farm in Nir-Banim, Israel. Clean birds and a guinea pig inoculated with the isolate died of the infection, or were killed in extremis. Y. pseudotuberculosis showing the same cultural characteristics as the original isolate was recovered from these animals. This is the first reported case of this infection from Israel.

Animals↗