[Possibilities and limits in radiological diagnosis (author's transl)].
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Biomedical subjects
Publications and source records attributed to J Wellauer.
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A significant decrease in mortality due to breast cancer is feasible only by earlier diagnosis. The decisive screening method is mammography, which permits identification of a malignancy in its earliest stages. Indirect and direct signs of malignancy exist whose detection necessitates biopsy. Radiological examination of the tissue sample permits evaluation of the adequacy of excision and thus renders possible specific histological examination of the region of interest. Pneumocystography is a method for simultaneous diagnosis and therapy of benign cysts.
The diagnosis of coronary aneurysms has for a long time been made at autopsy. After a general review of coronary artery aneurysms, a large aneurysm of the circumflex branch of the left coronary is described; this was diagnosed by selective coronary angiography and successfully treated by surgery. The results are compared with six other reported cases of pre-operatively diagnosed coronary artery aneurysms. Since complications, such as rupture, embolisation or infarction, are common in large coronary aneurysms, early diagnosis is desirable. An abnormal bulge of the cardiac contour or circular calcification within or at the edge of the cardiac shadow may be suggestive of the diagnosis.
A case with a probable diagnosis of a limited form of Wegener's granulomatosis is presented. Arteriography of an involved kidney revealed arterial occlusions and stenoses with infarcted parenchymal regions and a distinct collateral circulation. Compared to the renal changes in other collagenous diseases, the renovasographic findings in this case were more prominent, more centrally located, and of segmental distribution.
A case of diffuse lymphangiomyomatosis with involvement of the large veins of the body is reported. The clinical, pathologoanatomic and especially the roentgenologic findings are described. Interstitial lung thickening, pleural effusions and spontaneous pneumothorax are findings which together with a stasis in the lymphatic system strongly suggest the diagnosis. The extensive involvement of the venous system supports the theory of a hamartomatous nature of the disease.
The existence of several very impressive spinal paroxysms after lumbar myelography with Dimer-X1 caused us to make a retrospective investigation of 327 patients with 355 myelographies. In 7.1% of the investigations we have found partly heavy, but mostly reversible neurological complications. The latter cannot be classified, contrary to prevailing statements, in spinal, meningeal or cerebral reactions, since mostly all 3 anatomical structures are being concerned. Corresponding casuistical information are being presented and with their neurological symptomatic discussed. The spinal paroxysms appeared approximately 6 hours after the myelography and lasted over 8-10 hours, in spite of intensive therapeutical efforts. The pathogenesis points to a multifactorial occurrence caused by the coincidence of an increased dosage of the contrast media, too bed rest time, rising of the contrast media in the spinal cord zone and disturbed liquor fluid circulation and contrast media resorption. Pathophysiologically is in connection with spinal cramps an epileptic mechanism probable. Additional spinal reflexive components could be an explanation for the little therapeutical effect of Diacepam (Valium), which is contrary to the statement in the literature. We have seen a better effect in particular cases with Phenothiazine. With strict observance of specific precautionary measures, the Dimer-X seems to be a good media for the presentation of the lumbar subarachnoid space. A further development in this field is desirable.
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The effect of successful aortocoronary artery bypass surgery on left ventricular (LV) function was studied by angiography in 13 patients with coronary-artery disease and resection of a ventricular aneurysm. The following were calculated from single-plane right anterior oblique LV cine-angiograms: LV end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), percentage shortening of the medial perpendicular short axis (deltaM), mean velocity shortening of the circumferential fibres (VCF). The changes in the five hemi-axes of the anterior LV wall, and five of the inferior wall were averaged to give a value for relative anterior wall motion (SMV) and inferior wall motion (SMH). Changes in apical motion (SMS) were calculated from the percentage changes in the base-to-apex axis. The following mean values (x plus or minus s) were obtained four months before and 11 months after aneurysmectomy: EDVI (ml/m2) 154 plus or minus 27 (126 plus or minus 23), ESVI (ml/m2) 107 plus or minus 28 (56 plus or minus 15), SVI (ML/M2) 46.5 plus or minus 12.7 (69.9 plus or minus 23.1), EF (%) 32.6 plus or minus 8.0 (54.6 plus or minus 12.0), SMV (%) 6.1 plus or minus 10.0 (25.0 plus or minus 13.4), SMH (%) 25.9 plus or minus 13.1 (31.2 plus or minus 11.1), SMS (%) 5.1 PLus or minus 3.4 (13.1 plus or minus 4.2). These results indicated significant improvement in ventricular pumping action and wall motion after aneurysm resection and aortacoronary bypass surgery in patients with coronary-artery disease and severe cardiac failure.
Based on a review of 123 consecutive examinations a classification of ten types of meatocisternograms is proposed. Surgical correlation in 53 of these cases has shown that other causes of intrameatal filling defects may mimic acoustic neurinoma presence. Furthermore, grouping of these 123 patients into three clinical groups on the basis of symptoms and findings has not resulted in a clear type correlation when using a mixture of the ethyl esters of 9- and 10- monoiodostearates (Duroliopaque). Based on an experience using this classification in well over 500 meatocisternograms, several proposals are made for the clinical management of cases of clear-cut or suspect acoustic neurinomas.
Because of its particular photoelectric properties, xero-tomography is particularly suited for the investigation of abnormalities in the hilar regions. It is superior to conventional tomography because of the improved edge contrast, which emphasises details of relatively non-opaque structures, and because of its high exposure latitude. This justifies its use despite the higher radiation dose that is necessary. The demonstration of relatively dense and of more transradient tissues on the same picture by xero-tomography, and the ability to read it by ordinary light, makes it less tiring to interpret than the translucencies of conventional radiographs.
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The cineangiographically determined left ventricular function was studied in normals and in CAD-patients with one- and three-vessel disease. From single plane RAO-LV-cineangiograms following parameters were calculated; LV-volumes (EDV, ESV) according to the area-length method, ejection fraction (EF), percentage shortening of the medial perpendicular short axis delta (M,deltaMpl), mean velocity of circumferential fiber shortening (V(CF), V(CFPL)). It can be concluded that there is 1. no correlation between the severity of coronary heart disease and the morphological left ventricular wall lesions, 2. a depressed left ventricular function in coronary heart disease and normal ventriculograms, 3. a more impaired left ventricular function when cineangiograms show hypokinesis or aneurysms, 4. hypokinesis or aneurysms in the anterior wall leads to a more depressed left ventricular function than the same lesions in the posterior wall.
The left ventricular function was evaluated by a cineangiographic method. 28 normals and 36 patients with an isolated stenosis of the anterior descending branch of the left coronary artery underwent this procedure. From single plane RAO-LV-cineangiograms following parameters were calculated: LV-volumens (EDV, ESV) according to the area-length method, ejection fraction (EF), percentage shortening of the medial perpendicular short axis (delta M, delta MPL), mean velocity of circumferential fiber shortening (VCF, VCFPL). Patients with comparable ramus anterior descendens branch findings can have normal- or abnormal pattern of LV-contraction. The critical cineangiographic parameters of left ventricular function are significantly decreased at rest in ramus anterior descendens lesions with normal systolic anterior wall motion in comparison to the normal collective. Hypokinesis, Akinesis and aneurysms deteriorate parameters of LV-function.
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