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Biomedical subjects

J Wentzel

Publications and source records attributed to J Wentzel.

27 records · Page 2Linked to original sources
PubMed1976

A search for linkage in cystic fibrosis.

Linkage between the locus for cystic fibrosis and other genetic markers was explored in 40 families from Birmingham and 20 from Manchester. No strong evidence was found for linkage with any of the markers examined. There was evidence against close linkage with ABO, HLA, and Rh.

Child↗
PubMed1972

Human leucocyte antigens in Crohn's disease and ulcerative colitis.

The frequency of occurrence of 15 of the commoner human leucocyte antigens was determined in 18 patients with Crohn's disease and in 16 patients with ulcerative colitis, using an in-vitro lymphocyte cytotoxicity test (Harris, Wentzel, Cocking, Dodsworth, and Ukaejiofo, 1970). The overall results showed that, with the exception of human leucocyte antigen 3 in patients with Crohn's disease, in neither disease was there any major difference in any of the other antigen frequencies compared with a panel of 50 healthy controls. Nor was there an excess frequency of any particular antigen occurring in both Crohn's disease and colitis.

Antigens↗
PubMedDate not supplied

HLA antigens and growth in diabetic children.

HLA types in 121 diabetic children in Newcastle are examined in relation to their growth records. The children's height at the onset of diabetes was normal, but fell away during the course of the disease; there was low mean height velocity and failure of bone development to keep pace with chronological age. The total series shows the expected excess of HLA antigens B8, B15 and Cw3 and deficit of B7. Children with B8 are of smaller stature adjusted for bone age than those without the antigen, while children with B7 appear to do better. The results suggest that within the diabetic spectrum of genotypes the HLA antigens are relevant to growth and development.

Adolescent↗
PubMedDate not supplied

HLA frequencies in Basques in Spain and in neighbouring populations.

HLA antigen and gene frequencies at the A, B, and C loci are examined in a sample of 181 Basques and 102 non-Basques in Bilbao, Spain. The most common associations of genes at the A and B loci are as in western Europe generally. The results are compared with gene frequencies in other Basque and non-Basque samples in Spain and France. There is clear distinction in gene frequency between Basques and non-Basques, to which the greatest contribution is made by A1 and B35, followed by B7, B8 and B12; and a difference between Basques in France and in Spain, notably in A28, 29, 30 and 31 and B17 and 18.

Ethnicity↗