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Biomedical subjects

J Werblowsky

Publications and source records attributed to J Werblowsky.

5 recordsLinked to original sources
PubMed1983

A controlled clinical trial of alprazolam for the treatment of anxiety.

The authors report the results of a large-scale double-blind study comparing the anxiolytic effects of alprazolam, a triazolobenzodiazepine; diazepam, a 1,4-benzodiazepine; and placebo in 151 anxious outpatients. Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam.

Adult↗
PubMed1982

Amitriptyline-perphenazine and doxepin in depressed outpatients: a controlled double-blind study.

Amitriptyline-perphenazine (100/8-150/12 mg/day) and doxepin (100-150 mg/day) were compared for clinical efficacy and safety in a sample of 130 nonpsychotic depressed outpatients. Maximum study duration was 4 weeks; 19 amitriptyline-perphenazine and 29 doxepin patients completed less than or equal to 3 weeks of treatment and 45 amitriptyline-perphenazine and 37 doxepin patients completed 4 weeks of treatment. Patients in both groups showed significant improvement in depression, but amitriptyline-perphenazine produced greater improvement than doxepin on several measures of depressive symptomatology. The incidence of anticholinergic and sedative side effects was higher in the amitriptyline-perphenazine treated group.

Adult↗
PubMed1981

Homosexual incest.

Within the past two years, we have encountered two cases where homosexual incest seemed to be a potent predisposing factor in extreme pathological behavior. In order to better understand what we were contending with, an extensive search and review of the literature was undertaken and the two case histories analyzed in detail. Our conclusions include: (1) that homosexual incest is at times unrecognized by therapists and therefore not dealt with to alleviate torment and sometimes to avert tragic consequences; and (2) that it is underreported so that information is lacking and essential dialogue on dynamics and treatment rarely occurs. It is hoped that this article will stimulate awareness of the phenomenon and foster exchange of ideas regarding etiology, psychodynamics, and intervention.

Adult↗
PubMed1981

Amoxapine and imipramine in the treatment of depressed outpatients: a controlled study.

In a double-blind, controlled study 158 outpatients with unipolar depression were treated for six weeks with amoxapine, imipramine, or placebo to assess the antidepressant effects of the new dibenzooxazepine compound, amoxapine. Forty-five amoxapine, 43 imipramine, and 27 placebo patients completed at least four weeks of treatment. Active drugs produced significantly more improvement at treatment endpoint, according to several physician-rated measures, but patient-rated measures failed to differentiate among treatments. Both active drugs at daily doses up to 200 mg produced an equal amount of moderate and marked global improvement, and both produced significantly more side effects than did placebo.

Amoxapine↗