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Biomedical subjects

J Wessely

Publications and source records attributed to J Wessely.

At least 19 recordsLinked to original sources

[Relation between the body weight of the pregnant patient and her serum alpha fetoprotein levels].

In 1000 singleton pregnancies between 16 and 18 weeks maternal serum alpha-fetoprotein (AFP) levels were related to maternal weight. The heavier women had lower mean levels apparently as a result of the diluting effect of larger blood volume. Lighter women had higher AFP levels, perhaps on account of the greater concentration of AFP in their relatively smaller volume of blood. A policy of evaluating the maternal serum AFP level according to maternal weight among women with borderline positive results could reduce both the number of patients having a diagnostic amniocentesis, and the rate of false negative cases.

Amniocentesis

[Electrodynamic discrepancy of the heart].

Electrodynamic discrepancy was observed in the hearts of 15 out of 144 patients with myocardial infarction who died on account of various complications. Autopsy revealed cardiac rupture with pericardial tamponade in each of the 15 cases. If the ECG shows no typical signs of a myocardial infarction, then with great probability an aortic rupture is present. The pathomechanism of electrodynamic discrepancy of the heart may be explained with the help of Laplace's law and "neuropraxia", "Afterload" and "preload" are reduced to practically nil, the tension of the myocardial walls falls, the effective work of the heart muscle stops and with the considerably lower oxygen requirement of the myocardium the bioelectric activity of the heart is still maintained for 12-30 minutes.

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