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Biomedical subjects

J Whiteley

Publications and source records attributed to J Whiteley.

7 recordsLinked to original sources
PubMed1989

Synergy between 5,10-dideaza-5,6,7,8-tetrahydrofolic acid and methotrexate in mice bearing L1210 tumors.

In vivo studies with 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), an inhibitor of glycinamide ribonucleotide transformylase, indicate that at doses ranging from 2.5 to 10 mg/kg, it prolongs the survival of mice implanted with L1210 tumors. Lower doses of this agent have no effect. Parallel studies with methotrexate indicate that DDATHF is not as potent or as efficacious as methotrexate in this animal model. Low doses of DDATHF combined with low doses of methotrexate can cause a significant increase in the survival of L1210 tumor-bearing mice, suggesting synergism between these two antifolates.

Animals↗
PubMed1976

Serum proline imino-peptidase activity in normal adult subjects and in patients with Paget's disease of bone.

The activity of proline imino-peptidase (EC 3.4.1.4) may provide a measure of collagen degradation, and a method for its estimation in human serum is described. The mean value of this enzyme activity in 48 normal adults of 4.7 mU/l (S.D. 0.9) did not change with sex, age or dietary collagen. In 8 patients with liver disease associated with elevated levels of plasma alkaline phosphatase activity the mean value was normal (4.5 mU/l, S.D. 1.5). However, in 25 patients with untreated Paget's disease of bone, values were significantly increased (mean 7.4 mU/l; S.D. 2.8; p less than 0.001) and were positively correlated with plasma alkaline phosphatase activity (r = 0.75; p less than 0.001) and with urine total hydroxyproline excretion (r = 0.68; p less than 0.001). In patients given disodium ethane-1-hydroxy-1,1-diphosphonate for 3--6 months, serum proline imino-peptidase activity decreased to normal values.

Adult↗
PubMedDate not supplied

Squamous-cell carcinoma of the floor of the mouth.

Among the histologic parameters described by Jakobsson, only the stage (depth) of invasion appears to be of value in predicting lymph node metastases. Early carcinomas of the FOM examined in our institution (T1 and some T2) grew in a superficial or horizontal manner and none developed metastases or local recurrence. Larger neoplasms (some T2 and all T3 and T4) had extensive submucosal and deep soft tissue infiltration and a corresponding high frequency of regional lymph node metastases. T1 and T2 neoplasms with only superficial or microinvasion of the submucosa have little or no propensity for lymph node metastases while T2 cancers with nodular or vertical in filtration into the submucosa have a substantial frequency of metastatic disease (44%). If the biopsy sites are carefully selected, these growth patterns can be identified by the pathologist. In addition, our experience is that clinical assessment of cervical lymph nodes for the presence of metastatic disease is often erroneous. Rates of 56% false positives and 24% false negatives were observed, which were similar to rates reported in other series. Biopsy evaluation of the extent and growth pattern of the primary neoplasm is as important as physical examination in determining the type of surgery to be done and whether lymph node dissection should be performed.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

The Mersey beat.

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Education, Nursing, Continuing↗