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Biomedical subjects

J Wieckowski

Publications and source records attributed to J Wieckowski.

16 recordsLinked to original sources
PubMed1993

Creation of experimental urethral obstruction in utero: evaluation of fetal renal function.

Management of obstructive uropathy diagnosed in utero would be markedly enhanced by the availability of a simple, safe and quantitative fetal renal function test to predict postnatal renal function. In order to allow experimental evaluation of such a parameter, we adjusted a model of complete urethral obstruction with urachal ligation in 30 fetal lambs at 79 or 99 days of gestation. The method described allows obstruction in male and female fetuses as early as 79 days of gestation, with an overall high survival rate (control: 12/14; obstructed: 23/29), although lower (6/12) when obstruction is performed early (79 days) during gestation. Consequences of obstruction were examined on the 121st day of gestation. Severe hydronephrosis, ureteral and calyceal dilatation, with or without ascites and pulmonary hypoplasia were observed in all fetuses; creatinine clearance determined in utero was decreased in both groups with obstruction (early and late) vs control group: 1.15 +/- 0.5, NS, and 0.58 +/- 0.4, p < 0.01 vs 1.61 +/- 0.8 ml/min/kg respectively. In both obstructed groups, fetuses with ascites displayed lower plasma creatinine concentration and higher creatinine clearance values when compared to fetuses without ascites. In conclusion, the experimental model of obstructive uropathy described appears efficient and easily reproducible, allowing therefore the evaluation of a predictive parameter of postnatal renal function. Our preliminary results suggest that renal fetal function is more dependent on the degree of obstruction than on the term of its creation.

Animals↗
PubMed1989

[Treatment of an undescended testis with human chorionic gonadotropin (HCG)].

Seventy one patients with ectopic testis of age between 2 and 11.5 years were treated with human chorionic gonadotropin (HCG) at doses recommended by the International Health Foundation. The descent of testis to the scrotum was achieved in almost half of the treated boys (49.3%). The descent was successful mainly in cases of lower inguinal position of the undescended testicle, and only rarely when the testicle was situated higher. The descent was never successful in cases when the scrotum was small and underdeveloped.

Age Factors↗
PubMed1979

Maintaining the lung disease patient at home.

A pilot home care program for lung disease patients has been set up by a lung association, in conjunction with local hospitals and home care agencies. The emphasis is on long-term care and support of services for which home care agencies would not ordinarily be reimbursed.

Emphysema↗
PubMed1973

Dystrophic chicken muscle: altered synaptic acetylcholinesterase.

Individual motor endplates in the skeletal muscles of chickens genetically homozygous for muscular dystrophy have been compared with those in normal chickens. Measurements were made there, by specific autoradiographic techniques, of the numbers of total cholinesterase-like molecules and of acetylcholinesterase molecules. The acetylcholinesterase is distinctly decreased at the endplates in dystrophic muscles. The various data available on these muscles are compatible with the concept that a neural factor which determines the synaptic acetylcholinesterase, along with a number of other characters in the muscle cell, is defective in this disorder.

Acetylcholinesterase↗
PubMedDate not supplied

[Small intestine transplantation--current status of animal experiments].

The most frequently used methods are discussed of small intestine transplantation (SIT) in experimental models. The advantages and drawbacks of various operational techniques are characterized. The problems are presented associated with the intensity of graft rejection reaction. The presently used methods of preservation of small intestine taken for transplantation are discussed.

Animals↗
PubMedDate not supplied

[Small intestine transplantation--immunologic problems in experimental studies].

The basic immunological problems are discussed associated with small transplantation (SIT) in experimental models. The types of immunological reactions are characterized. The status is presented of studies on the used methods of immunosuppression and the decrease of immunogenicity of graft. The role is stressed of histological monitoring of graft rejection reaction.

Animals↗
PubMedDate not supplied

[Small intestine transplantation in the human--clinical studies].

Three stages in development of small bowel transplantation (SBT) in a human are discussed. Indications to SBT in adults and children are mentioned. Clinical experiences in SBT in humans with particular presentation of actual problems, difficulties and future of SBT are discussed.

Adult↗