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J Wiedmayer

Publications and source records attributed to J Wiedmayer.

2 recordsLinked to original sources

[Malignant cerebellar infarct].

Three patients with cerebellar infarcts and secondary obstructive hydrocephalus (hydrocephalus occlusus) are described, the condition being due to the space-occupying action of the ischaemia and oedema zone with compression and displacement of the fourth ventricle and/or obstruction of the aqueduct. Possible brain stem compression and danger of cerebellar tonsillar herniation were present. From the acute deterioration of the clinical picture, particularly of the state of consciousness, as well as from the findings obtained via computed tomography showing a widening of the inner ventricular space, it was imperative to perform emergency pressure-relieving drainage surgery with ventriculo-atrial shunts in all the cases described. The first two patients could be discharged postoperatively with successful treatment, only slight neurological disturbances remaining. This leads to the conclusion that a (malignant) cerebral infarct should be treated as an emergency case, in a somewhat similar way as in cases of cerebellar haemorrhage or other space-occupying lesions in the posterior fossa of the skull. To recognize the life-threatening exacerbation, sufficient observation and supervision will be necessary. Rapid deterioration in consciousness should be considered a sign of increasing intracranial pressure progressing with the development of hydrocephalus internus occlusus. After neuroradiological diagnosis, especially after verification via computed tomography, this should be interpreted as an indication for immediate neurosurgical intervention. This is the only way to keep the mortality rate satisfactorily low. Dichotomy of cerebellar infarcts into a benign type with spontaneous decrease of symptoms and signs, and a malignant type with development of hydrocephalus internus and increased intracranial pressure, such as in the cases described here, is suggested.

Cerebellum↗

[Therapy of acute schizophrenic attacks. High dosage haloperidol therapy compared with a two component treatment].

In a controlled open study 18 patients were treated with high doses of haloperidol (Haldol-Janssen) from 50 to 100 mg daily and 15 patients with a combined therapy of 10 mg haloperidol and 150 to 300 mg levomepromazin (Neurocil). The high-dosed sample a significantly rapid decrease of the productive symptoms and improvement of the general condition were found. The medians of the rating scales and self-rating scales showed similar courses. Within the high-dosage group especially after the beginning of therapy, there was an unexpected significant increase in extrapyramidal signs (dyskinesias), which did not appear any more after starting with an initial dose of at least 50 mg Haldol-Janssen. Other side effects could not be found, the tolerance was good.

Anxiety↗