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J Witchitz

Publications and source records attributed to J Witchitz.

At least 19 recordsLinked to original sources
PubMed1982

[Gram negative bacilli endocarditis ].

Gram negative bacilli endocarditis are unfrequent. Nevertheless we encountered 28 cases of them (8.8%) among 320 endocarditis of which 10 were primitive and 7 cases (10.9%) among 65 prosthetic endocarditis. Bacterial species were 12 Pseudomonas aeruginosa, 2 Ps, stutzeri, 1 Ps. maltophilia, 2 Klebsiella pneumoniae, 2 Escherichia coli, 3 Serratia marcescans, 1 Enterobacter cloacae, 1 Brucella, 1 Hemophilus aphrophilus, 1 Fusobacterium funduliformis, 18 cases were hospital acquired infections related to cardiac surgery (4 cases), intracardiac catheterization (5 cases), intravenous catheter (4 cases). Uncontrolled infection or cardiac insufficiency underwent respectively in 14 and 18 cases. The overall mortality was 50 p. cent. The death occurred more frequently in primitive endocarditis (70%) than in secondary native endocarditis (45%) or prosthetic endocarditis (29%). It was also more frequent in Pseudomonas endocarditis (59%) than with other species (36%) and more frequent when cardiac sufficiency was present (50%). 15 patients underwent surgical procedure of which 6 died (40%). The results were better if the infection was cured before surgical procedures: 5 deaths occurred when the culture of the valves remained positive (9 cases) but none when it was negative. The 5 most recent cases of prosthetic endocarditis were cured. Since 1979, no death occurred among treated patients. we concluded that surgery is usually necessary but after an effective antibiotic therapy over a 4 or 6 week period.

Adolescent↗
PubMed1979

[Pneumococcal serotyping. Multicentric inventory in hospital. Years 1977-1978 (author's transl)].

For a period of 17 months, 670 pneumococci, mostly isolated in the Paris area, have been typed with contercurrent-immunoelectrophoresis ; 338 of them come from cases of pneumonia, bacteremia, meningitis and acute otitis media. An important regrouping of the most frequent serotypes among the 83 known serotypes makes possible a vaccinal prophylaxis. The tetradecavalent vaccine which is now for sale in USA gives, in the four main pathologies of this enquiry, a coverage superior to 80 percent. Choosing the 14 most frequent serotypes of the four main pathologies of their data the authors propose the following vaccinal formula : 1, 3, 4, 5, 6, 7, 8, 10, 12, 14, 15, 18, 19, 23.

Adolescent↗
PubMed1976

Pseudomonas aeruginosa endocarditis. A report of nine cases.

9 cases of Pseudomonas aeruginosa endocarditis are reported and the results of this study are compared with the data of the literature. The source of infection was known in 8 patients: 7 were nosocomial infections (cardiac catheterization in 5 cases, cardiac surgery in 2 cases). The diagnosis was made in 8 patients with left-sided endocarditis. In 1 patient tricuspid endocarditis was diagnosed on postmortem examination. Carbenicillin associated with an aminoglycoside antibiotic appeared to be the most effective treatment when prescribed for several weeks. 6 of 9 patients died of uncontrolled septicemia, 3 of whom underwent surgery which was twice performed because of poor hemodynamic status. In the other 3 patients drug administration was effective at first. However, a relapse occurred in these three cases compelling another effective antibiotic therapy. Surgery was peformed in these three patients. Valve cultures were negative in two cases and positive in 1. These 3 patients survived. They are still alive after a follow-up period of 2 or 3 years.

Adult↗
PubMed1974

3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor.

A new R factor-mediated gentamicin acetyltransferase obtained from a clinical isolate of gentamicin-, tobramycin-, and kanamycin-resistant Klebsiella was characterized. R factor R 176 was transferred to Escherichia coli K-12 LA 290 from a Klebsiella. Resistance transfer, minimal inhibitory concentrations of various aminoglycoside antibiotics, enzymatic inactivation, and the isoelectric point of the enzyme obtained were determined. We found that R factor R 176 could govern the enzymatic 3-N acetylation of gentamicin, tobramycin, and kanamycin, and isoelectric point determinations suggested that the enzymes governed by R 176 and R 135 are different. The genes responsible for resistance to gentamicin, tobramycin, and kanamycin govern the synthesis of an isoenzyme of AAC(3)I, which we propose to call AAC(3)II.

Acetylation↗