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Biomedical subjects

J Witte

Publications and source records attributed to J Witte.

35 records · Page 2Linked to original sources
PubMed1977

Metastatic choriocarcinoma transplanted with cadaver kidney: a case report.

A unique case of a metastasising choriocarcinoma, inadvertently transplanted to a man from a female cadaver kidney is reported. When the kidney was removed six days after transplantation, arterial blood vessel infiltration by chorio-carcinoma cells and high levels of human chorionic gonadotropin (HCG) in the serum of the recipient indicated an haematogenous dissemination of viable neoplastic cells. The immunosuppressive therapy was discontinued after removal of the graft and the HCG levels in the recipient gradually decreased over a periode of eight weeks, indicating a slow immunologic rejection of the tumor cells. The recipient committed suicide seven months after the transplantation had failed. No metastases were found at a legal autopsy. It seems advisable, whenever there is evidence that neoplastic cells might have been transfered by a homograft, to remove the graft and discontinue the immunosuppressive therapy. Neoplastic cells already disseminated can still be eliminated when the immunologic system is intact and not suppressed.

Cadaver↗
PubMed1977

[The significance of sodium intake in postoperative aldosteronism].

The postop. aldosteronism of a control-group with a sodium intake of 1.5 mval/kg bw/d can be suppressed by increasing the sodium intake up to 5 mval/kg bw/d. A postop. increased need for sodium is supposed to be the most possible cause for this aldosteronism.

Aldosterone↗
PubMed1977

[Manometric study on the effect of proximal vagotomy on the lower esophageal sphincter].

Selective proximal vagotomy (SPV) decreases the LES pressure (resting pressure and pentagastrin-stimulated pressure), significantly 6 months postoperatively without achieving LES insufficiency by clinical means. Immediately after stimulation LES pressure is identical, compared to preoperative measurements. The postoperative significantly increased concentration of basal gastrin seems not to be a major determinant of LES tone in humans.

Adult↗
PubMed1976

[Haemobilia as a special form of gastro-intestinal bleeding (author's transl)].

Nine patients with haemobilia were treated during a 17-year period (1958-1974), seven of them with postoperative haemobilia after operations on the biliary tract, and one with traumatic haemobilia. Three patients with intrahepatic injury after transhepatic drainage for inflammatory biliary-tract stricture or after extraction of intrahepatic biliary-tract stones with a Fogarty catheter were free of symptoms on conservative treatment alone. Of six operated patients one died from extensive hepatic necrosis after ligation of the main and right hepatic arteries, another two months after operation of septicaemia. The other patients have remained free of symptoms.

Adult↗
PubMed1976

[Manometric studies on the influence of selective proximal vagotomy on the lower esophageal sphincter].

Selective proximal vagotomy (SPV) decreases the LES pressure (resting pressure and pentagastrin-stimulated pressure), significantly 6 months postoperatively without achieving LES insufficiency by clinical means. Immediately after stimulation LES pressure is identical, compared to preoperative measurements. Concentration of serum gastrin is not a major determinant of LES tone in humans.

Cardia↗
PubMed1975

Metabolic and structural recovery of left ventricular canine myocardium from regional complete ischemia.

The capacity for recovery of the normothermic left ventricular myocardium from a regional complete ischemia (RCI) was investigated using changes in the myocardial metabolic status (ATP, ADP, AMP, creatine phosphate (CrP), free creatine, glycogen, glucose, lactate) and alterations of the morphology as parameters. In dogs, an area of the anterior wall of the left ventricular myocardium was temporarily deprived completely of its blood supply by 5--7 overlapping ligatures extending into the heart cavity. The metabolites of the adenylic acid-CrP system returned to normal tissue levels after 30 and 60 min of RCI within 14 and 35 days of recovery, respectively; restoration averaged 82% after 100 min, 74% after 140 min, and 38% after 180 min of RCI after 5 weeks of recovery. At the same time glycogen amounted to 163% after 100 min, 114% min, and 65% after 180 min of RCI. The biochemical data correlated well with the structural changes in the affected myocardium, especially with the amount of de- and regenerating heart muscle cells. These obviously were functionally defect and were not comparable with normal structured and functioning heart muscle cells.

Adenosine Diphosphate↗
PubMed1975

The value of quantitative apex-cardiography as compared to intracardiac functional diagnostics of the left ventricle.

A quantitative procedure of recording the apex impulse as regards its duration, force and rate of development of force requires a DC amplification ensured by a semiconductor strain-gauge transducer. In addition, impact and diameter or stamp and internal diameter of the contact ring must be defined. Comparative measurements show a good correlation between timing, absolute values and the first derivatives.

Cardiac Catheterization↗
PubMed1975

Effect on myocardial metabolic pattern of local complete and incomplete ischemia.

After local complete ischemia at normothermia of 60, 100, 140, and 180 min duration the status of the adenylic acid-creatine phosphate system in the canine myocardium recovered to 98, 85, 74, and 30 percent of the control values, whereas glycogen was restored even more. In the infarcted myocardium the extent of alterations of the metabolic status was a function of the residual blood flow. Deviations from a regular metabolic status developed if the blood flow dropped below about 35 ml/min/100 gm. This critical flow rate is expected to vary with the energy requirement of the heart, but it is in keeping with results obtained by Rudolph and coworkers (personal communication) who found that patients with a myocardial blood flow below 30 ml/min/100 gm had a life expectancy of less than 1 month. In the nonaffected myocardium, both in experiments with local complete ischemia and in experiments with infarction, the metabolic status was always within normal ranges. This is in contrast to results published by Gudbjarnason (1971/1972) and Gudbjarnason, Puri, and Mathes (1971), who found that in noninfarcted myocardium tissue levels of ATP and creatine phosphate decreased to about 50 percent of the control values and that there was no restoration to normal values within 10 days after infarction.

Adenosine Monophosphate↗