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J Y Lettvin

Publications and source records attributed to J Y Lettvin.

At least 19 recordsLinked to original sources
PubMed1999

Selective, unilateral, reversible loss of behavioral responses to looming stimuli after injection of tetrodotoxin of cadmium chloride into the frog optic nerve.

Unilateral injection of tetrodotoxin or cadmium chloride into the frog optic nerve selectively eliminates behavioral responses to looming stimuli while sparing responses to prey stimuli. This behavioral loss is correlated with a loss of activity of "dimming" units in tectal layer G. These findings suggest that separate sets of retinal ganglion cell fibers carry information concerning looming stimuli and prey stimuli. The lack of activity in layer G suggests that information about looming stimuli is being conveyed by myelinated retinal ganglion cell axons. It is argued that unmyelinated fibers are not blocked by the neurotoxins because the extracellular space around the fibers is mostly inaccessible.

Animals↗
PubMed1997

A compartment-based, asymmetric representation of the retina in an induced projection to the olfactory cortex.

Displacing the optic nerve into the telencephalon in adult Rana pipiens induces a projection to olfactory cortex. We have examined the topographic organization of this projection anatomically by injecting a mixture of biotin dextran (BDA) with 3H-amino acids into the affected eye immediately after making cuts across defined sectors of the nerve fiber layer to trace the complementary patterns of anterograde migration of BDA and 3H label in the cut and intact retinal axons, respectively. Fibers from the temporal side of the optic disc terminated in an oblique band along the posterior two-thirds or more of the ectopic projection field. In contrast, fibers arising in the nasal retina terminated in a parallel strip occupying the anterior one-third or less of the field. Varying the location of the cuts within each hemiretina did not reveal any further organization along the nasotemporal or dorsoventral axes of the retina. The retinal location of the cells involved in this projection was further studied with injections of wheat germ agglutinin conjugated to horseradish peroxidase into the olfactory cortex. Ganglion cells labeled by retrograde transport were found throughout the retina, but they were much more numerous on the temporal side, having a mean spatial density 3.7-7.4 times greater in the temporal hemiretina, whereas the overall ganglion cell density (labeled plus unlabeled) was roughly the same in the two halves of the retina. These data provide an example of a permanent projection in which the overall representation of the retina, though nontopological, is polarized in one axis (nasotemporal) and, therefore, compartmentally organized.

Animals↗
PubMed1996

Concentration and storage of biotin in the amphibian brain.

Prominent displays of endogenous biotin reactivity can be observed at specific locations in histochemical preparations of the forebrain and midbrain in the northern leopard frog (Rana pipiens) and common American toad (Bufo americanus). At the light microscopic level, the biotin reactivity appears in clusters of darkly stained puncta of either spherical or rodlike shape in the olfactory cortex, nucleus isthmi, and hypothalamus. With the electron microscope, the biotin reactive spheres are identified as neuronal varicosities and synaptic boutons and the rods as short segments of axons. Appropriate controls demonstrate that the punctate biotin-reactive structures are sites of concentration of biotin or a biotin analog in the processes of certain neurons. These data represent the first observation on the selective concentration of a vitamin in vertebrate neurons and suggest that biotin may have specialized functions in anatomically delimited areas of the central nervous system. Localization of the densest concentration of the biotin-reactive puncta in the dorsolateral prominence of the olfactory cortex may have relevance to the functional organization of the olfactory system. The distributions of biotin-reactive puncta were observed in laboratory-housed frogs and in wild toads captured in the summer months but were sparse or absent in batches of commercially obtained frogs examined immediately upon arrival in the laboratory. Systemic administration of biotin or biocytin hydrochloride did not alter the appearance or numbers of the biotin-reactive structures either in newly received or laboratory-housed frogs. These findings suggest that the capacity of the biotin-storage mechanism in the amphibian brain may be set by environmental factors and may be readily saturable from natural dietary or enteric sources.

Animals↗
PubMed1995

Functional properties of regenerated optic axons terminating in the primary olfactory cortex.

When the optic nerve of Rana pipiens is cut and deflected into the telencephalon, the regenerating fibers terminate selectively in the superficial neuropil of the primary olfactory cortex. These redirected fibers and their terminals on the dendrites of the cortical cells appear normal by LM and EM criteria. Electrical recording, done 2-16 months after surgery, shows visually evoked activity in the superficial neuropil (Layer I) of the olfactory cortex, and visually excited responses in the deep cortical cell layer (Layer II). In the normal frog, the electrical activity seen in the neuropil of the olfactory cortex consists of small transients about 2-3 x the noise level of the electrode contact. These occur spontaneously and are also excited by puffs of air to the nose. There is no such excitation by visual stimuli. Larger initially negative spikes cell above noise level are recorded in the cell layer next to the ependymal surface, and these are also spontaneous, or excited by puffs of air to the nose, but not by visual stimuli. In the operated frog, the small transients in the neuropil appear and are excited by the puffs of air and by visual stimuli. Similarly the responses in the cell layer are excited by both sorts of stimuli. But new types of electrical signals appear in the neuropil; they are driven only by visual stimuli presented to the affected eye. These are very large transients of the kind found in the tectal neuropil and have the two characteristic shapes which were classified as B and C types in the tectum. Such large transients are never seen in the neuropil of the olfactory cortex in normal frogs. The receptive fields of the small visually driven transients in the neuropil are not easy to make out because the signal levels are so close to the noise level that different units cannot be reliably distinguished from each other. But the receptive fields of the much larger B and C type unit responses are as easy to classify and plot as they are in tectum, even though on the average they are only about 2/3 as large as in tectum. The single-unit receptive fields belong to one or another of the several types of retinal ganglion cell classes distinguished in optic-nerve recordings. Four of the major classes normally project to the tectum and a fifth projects to the lateral geniculate complex. But all five are present in the ectopic projection to the olfactory cortex.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1994

Dyslexic children learn a new visual strategy for reading: a controlled experiment.

Recent studies by Geiger, Lettvin and Zegarra-Moran have proposed a new non-reading test for the diagnosis of dyslexia, and a new method for remediation. The latter involves the learning of a "visual strategy". On adult dyslexics the test was reliable and the remediation apparently effective. The purpose of this study is to confirm the usefulness of the remediation and test with children. Dyslexic children (3rd-6th grade) were divided into two groups. The experimental group (9) was given a new remedial regimen of practise. The control group (6) continued the remedial process given in their school. After 3 months of practising their separate regimens all the dyslexic children who were in the two groups were retested and compared. The "experimental" dyslexics improved in reading by 1.22 grade level on average while the "control" dyslexics improved by 0.17 grade on average. The form-resolving field (FRF) plots narrowed significantly for the experimental dyslexics while they changed little for the control dyslexics. At the end of the second testing the control dyslexics were also given the new regimen of practise. Five months later all the dyslexic children were tested for the third time. The initial control dyslexics who later practised the regimen (2) improved in reading by 2-2.5 grades and their FRF plot narrowed. The experimental dyslexics continued to improve yet further. All the dyslexic who practised the new regimen started at an average of 2.5 grades behind their expected grade/age level and after 8 months were at an average 0.75 grades behind their expected grade/age level. This is on average 1.75 grade level improvement in reading within 8 months, a rate of improvement larger than that of ordinary reading subjects. The dyslexic children were compared with matched grade/age ordinary reading children for reference. The study confirms the usefulness of the test and the applicability of the remediation method for children. It also shows that improvement under that method is quite rapid.

Child↗
PubMed1992

Task-determined strategies of visual process.

Lateral masking in the peripheral field of vision obscures letter recognition and is not accounted for by diminished acuity. In measuring lateral masking between letters in the peripheral visual field we accidentally discovered that ordinary readers and severe dyslexics differ markedly in tachistoscopic letter recognition tasks. Tests were devised to measure the differences accurately. Ordinary readers recognize letters best in and near the center of gaze. Recognition falls off rapidly with angular distance in the peripheral field. Severe dyslexics recognize letters farther in the periphery in the direction of reading (English-natives to the right, Hebrew-natives to the left). They have marked lateral masking in and near the center of the field when letters are presented in aggregates. With dyslexia as an example, we proposed that the distribution of lateral masking is a task-dependent strategy in visual perception. To test this notion we designed an active practise regimen for 4 severe adult dyslexics, who within a few months improved sharply in reading. At the same time their test results changed to those of ordinary readers. We conclude that there are switchable task-determined pre-cognitive strategies of vision that can be learned and that the distribution of lateral masking may be part of what is learned.

Adolescent↗
PubMed1991

Sources of electrical transients in tectal neuropil of the frog, Rana pipiens.

We have studied the outer neuropil layers in frog tectum where the unmyelinated optic nerve fibers terminate. At any point in the neuropil an extracellular microelectrode records several different visually evoked electrical transients, distinct by size and shape. When classified by shape alone, each transient falls into one of 3 distinct classes. Some of these transients are binocularly driven, as originally described by Finch and Collett. The aggregate of the receptive fields of all the elements recorded at a single point defines a multiunit receptive field (MURF). Each MURF is characteristically oval, and divided into 3 sections along its long axis. Each section represents the aggregate of the receptive fields associated with one class of transient; i.e. transients belonging to only one specific class can be evoked by stimulating that part of the visual field corresponding to the appropriate section of the MURF. All of the MURFs mapped by recording in a single tectum are radially arranged in visual space about a central point, or 'visual pole'. Several conclusions are made. First, the two larger types of transient are generated postsynaptically by electrically active dendritic elements, specifically the beaded dendritic appendages of tectal neurons. The smallest type of transient is of presynaptic origin. Second, these tectal elements have a local and global anatomical order across the tectum, which accounts for both the tripartite structure of the MURFs and their radial arrangement about a visual pole. Third, since the large transients are of postsynaptic origin, genuine recordings of single retinal ganglion cell (RGC) activity can be made only in the optic nerve or retina itself. Fourth, information is conveyed over the unmyelinated optic nerve fibers at pulse rates as high as 80/s and is transsynaptically effective at such rates. Finally, the electrically active tectal dendritic elements, with their highly organized spatial arrangement, are an important component of the frog's visual processing apparatus, instead of being merely relays or repeaters.

Animals↗
PubMed1987

Peripheral vision in persons with dyslexia.

We compared persons with dyslexia and normal readers with respect to how well they identified letters and short strings of letters briefly presented in the peripheral visual field at the same time that a single letter was presented at the fixation point of gaze. We found that the dyslexic subjects had a markedly wider area in which correct identification occurred in the peripheral field than did the normal readers. However, the dyslexic subjects had a "masking" between letters in the foveal field and letters in the near periphery. It appears that dyslexic persons learn to read outside the foveal field and, more generally, that there are different learned strategies for task-directed vision. Among such strategies are different mutual interactions between foveal and peripheral vision.

Adolescent↗
PubMed1986

Enhancing the perception of form in peripheral vision.

Experiments are reported which show that the tachistoscopic presentation of a figure at the point of fixation makes salient the same figure where it occurs elsewhere in the visual field during the same flash. This induced saliency operates in all directions from the axis of gaze. If the eccentric figure is alone on a blank field the phenomenon is termed 'eccentric enhancement'. The induced saliency of figures that are laterally masked within horizontal strings of figures that lie off the fixation point is termed 'demasking'.

Attention↗
PubMed1980

Anatomy and physiology of a binocular system in the frog Rana pipiens.

The locations of tectal neurons projecting to nucleus isthmi (n. isthmi) were found by iontophoretic injection of horseradish peroxidase (HRP) into n. isthmi. After retrograde transport, stained tectal somata are found to lie almost exclusively in layer 6 and below of the ipsilateral tectum. Many cells are colored throughout the extent of their dendrites into the fine rami, giving the appearance of a Golgi stain. Nucleus isthmi receives projections from the ipsilateral tectum and from no other region. Nucleus isthmi units recorded electrically respond to visual stimuli and are arranged in a topographic map of the visual field. There are two types of receptive fields, those with small centers and those with large centers. The small centers are about 3-5 degrees in diameter, similar to type 2 optic nerve fibers. Their response is to many of the same geometric features of stimulus as excite type 2 fibers. The large centers are at least 7-10 degrees in diameter and respond to many of the same features as excite types 3 and 4 optic nerve fibers. The responsiveness of small and large center n. isthmi units is very similar to the elements of the ipsilateral visual field projection onto tectum, i.e. the neuropilar units recorded in layers A and 8 of the tectum when the contralateral eye is occluded. These are in strong contrast to those of tectal cells of layer 6 and below, which have large receptive fields, show far less vivacious response, adapt extremely rapidly to repeated stimuli and are hard to describe in terms of characteristic stimuli because they are unresponsive most of the time. We suggest, therefore, that the axons of tecto-isthmic cells are quite active and that their cell bodies, located in layer 6 and below, only fire occasionally on the firing of their axons.

Animals↗
PubMed1976

Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies.

This paper presents a set of probabilistic models which reproduce the proximodistal gradient of sensory deficit in peripheral neuropathies, on the basis of the occurrence of axonal dysfunction as a result of randomly distributed abnormalities. The models, which are based on conduction block, loss of temporal coherence, and weak interactions between nerve fibers, demonstrate that randomly distributed axonal dysfunction provides a sufficient condition for distal sensory deficit. The models predict a marked reduction in the length for normal sensory conduction with small increases in the probability of axomal dysfunction, providing a possible correlate for the rapid clinical progression of some neuropathies. The hypothesis that weak interactions between fibers result in paresthesiae in peripheral neuropathies is also discussed.

Humans↗