PubMed Health⌕ Search

Biomedical subjects

J You

Publications and source records attributed to J You.

95 records · Page 6Linked to original sources
PubMed1993

Characterization of endothelin-A receptors in the cerebral circulation.

Endothelin-1 (ET-1), a 21-amino acid peptide produced by the vascular endothelium, mediates contraction. In the present study we demonstrate that both ET-1 (Emax: 238 +/- 29% of potassium contraction) and ET-2 (Emax: 231 +/- 36%) produce strong concentration-dependent contractions of circular segments of guinea-pig middle cerebral artery, whereas ET-3 has only weak effects (Emax: 32 +/- 13%). FR 139317 (10(-6) M), a selective endothelinA (ETA) receptor antagonist, shifted the ET-1 response curve to the right (pD2:7.86 +/- 0.09 with and 8.76 +/- 0.09 without the antagonist) in a competitive manner (pA2 = 6.83). These findings are the first to show the presence of ETA receptors in cerebral vessels.

Animals↗
PubMed1993

Does the gender of the child affect acceptance of the one-child certificate? The case of Shaanxi province, China.

The author investigates the impact of gender on both acceptance of the one-child certificate and contraceptive use in Shaanxi province, China. "We found a weak association...in both the cross-classification and multiple classification analyses of the 1988 Two-per-Thousand Survey data. However,...[son preference] remains a clear tendency in rural areas, but the low proportion of the one-child certificate acceptors reflects the existence of stronger preferences for larger family size and specific sex composition.... By contrast, the high percentage of urban acceptors of the one-child certificate, regardless of the gender of the child, implies that son preference has decreased in urban areas of Shaanxi Province."

Asia↗
PubMed1992

[The antigastroulcerative activity of beta-sitosterol-beta-D-glucoside and its aglycone in rats].

Beta-sitosterol-beta-D-glucoside and its aglycone (the major constituent of the seed oil of Hippophae rhamnoides L.) were investigated for their antigastroulcerative activity in rats. Two experimental gastric ulcer models were selected: chronic acetic acid-induced ulcers and cold stress-induced ulcers. Both the glucoside and its aglycone showed antiulcerative activity in chronic acetic acid-induced gastric ulcer models, and their effects were at least comparable to the effects of wishupin in combination with cimetidine. The effect of aglycone appears better than the glucoside's. Glucoside also showed visibly antiulcerative effects on cold stress-induced ulcers, but wishupin combined with cimetidine did not have such effects.

Acetates↗
PubMedDate not supplied

Advances in the treatment and prophylaxis of Pneumocystis carinii pneumonia.

Pneumocystis carinii pneumonia (PCP) is the most common illness associated with the acquired immunodeficiency syndrome (AIDS) in the United States and also occurs in immunocompromised persons not infected with the human immunodeficiency virus.. Several advances have taken place in the treatment and prophylaxis of PCP, with most clinical trials conducted in patients with AIDS. Treatment of choice is trimethoprim-sulfamethoxazole (TMP-SMX). Desensitization regimens are available for those who have a fever or rash associated with the agent. Patients with severe PCP who cannot tolerate TMP-SMX may be treated successfully with pentamidine or trimetrexate. Those with mild to moderate disease may receive dapsone-trimethoprim, clindamycin-primaquine, or atovaquone if they cannot take TMP-SMX. Adjunctive therapy with corticosteroids improves the outcome in patients with AIDS and severe PCP.

Antifungal Agents↗