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Biomedical subjects

J Z Cinberg

Publications and source records attributed to J Z Cinberg.

10 recordsLinked to original sources
PubMed1985

Calvarial grafts for midface rehabilitation.

Access, pain, prolonged hospitalization, or inadequacy of consistency and quantity of a graft are drawbacks to traditional donor sites of autologous bone for reconstruction of severe midface trauma with bone loss. The sectioning of human skulls resulted in selection of the parietal bone as a technically feasible donor site for obtaining adequate autologous bone for the rehabilitation of generous defects in the floor of the orbit or the anterior maxillary wall. The examination of various animal skulls resulted in the selection of the large canine as an adequate experimental model to evaluate the technique. The parietal bone served as a harvest site, without morbidity, for autologous bone used to fill in the defects in the orbit and anterior malar wall in the live canine model. Subsequently, human autografts of outer cranial table parietal bone provided adequate material to repair severe floor of orbit and maxillary defects with minimal patient discomfort and donor site morbidity.

Adult↗
PubMed1983

An application of immunocytology to the analysis of the cell kinetics of upper respiratory and digestive tract squamous carcinoma.

An antinucleoside immunofluorescence technique (ANIF) facilitated evaluation of labeling index (LI) from frozen sections of 36 upper respiratory and digestive tract squamous cancers (URDTS) from a group of 35 patients. There were 35 URDTS of the larynx, oral cavity, or pharynx and the LIs of this population ranged from 0-39.4%, (mean, 14.7%); 6% of URDTS (2 of 36) were not assessable by ANIF. The administration of nontherapeutic radioactive materials, the establishment of cell cultures, and perturbations in cell growth implicit in the removal of tumor from host prior to assessment are unnecessary in the application of this technique.

Carcinoma, Squamous Cell↗
PubMed1983

Tumor mapping: new rationales, adjusted techniques, expanded applications.

Eleven consecutive patients with cancers of the oropharynx (4), hypopharynx (4), and oral cavity (3) were endoscoped and "tumor mapped" with a modified tattoo solution before beginning non-surgical antineoplastic therapy. The tattooed outlines were clearly visible at 7 weeks (5 patients after induction chemotherapy); at 14 weeks (2 patients after induction chemotherapy and radiotherapy); and between 12 and 16 weeks (4 patients after radiotherapy). The "tumor mapping" aided both the establishment of appropriate resection margins in cancers that had diminished in response to non-surgical therapy and the recognition of a tumor's lack of response to nonsurgical antineoplastic treatment.

Carbon↗
PubMed1982

Cervical cysts: cancer until proven otherwise?

A cystic neck mass can be either malignant or benign; 22% of patients (4/18) admitted with the tentative diagnosis of branchial cyst in a recent 2-year period (1977-1979) had metastatic carcinoma: epidermoid, thyroid or salivary gland. Preoperative fine needle aspiration was diagnostic in 1 instance and unhelpful in 2. Frozen section analysis of the gross specimen invariably provided the correct diagnosis. All patients with malignancies had subclinical primary disease and in 1 instance random biopsies identified its origin. The prudent surgeon will avoid untoward results if he approaches a neck cyst in an adult as if it were malignant. Guidelines he can follow to prevent the inadvertent removal of a metastasis under the misapprehension that it is a benign neck cyst include: 1. Prior to operation, perform a thorough head and neck examination to identify a primary carcinoma; 2. Do a fine needle aspiration of the mass for cytology. A negative report must be considered inconclusive; 3. Make a gross examination in the operating room of the opened cyst and frozen section processing of suspicious areas; 4. Follow with a panendoscopy and random biopsies of appropriate areas and complete the neck dissection on the involved side, after a metastatic deposit has been recognized. The preoperative procurement of contingency consent for these procedures is understood.

Adult↗
PubMed1980

Thyroid carcinoma and secondary malignancy of the sinonasal tract.

The sinonasal tract in general and the maxillary antrum in particular are uncommon sites for primary or metastatic tumors. Recently a woman had severe left posterior epistaxis. Hemorrhagic thyroid tissue was in the left maxillary sinus. The patient also had roentgenographic and scintigraphic evidence suggestive of thyroid tissue in her lungs and spine. Sixteen years previously she had undergone a partial lobectomy for a thyroid tumor. Reports of metastatic thyroid carcinoma in the maxillary, ethmoid, or sphenoid sinuses apparently have not appeared previously in the literature. Thyroid carcinoma's ability to metastasize to a paranasal sinus is documented now, and the list of tumors of the sinonasal tract are to be included in the differential diagnosis of epistaxis increases.

Adenocarcinoma↗
PubMed1980

The percentage of cells in DNA synthesis in epidermoid carcinomas of the head and neck: a preliminary report.

The in vivo study of cell kinetics of squamous carcinomas of the head and neck is in its infancy. One cell kinetic parameter, the labelling index (LI), the percentage of cells actively replicating DNA, was estimated in carcinomas of the oral cavity (10), larynx (6) and pharynx(5) by an histochemical immunoglobulin technique developed recently in our laboratory: the antinucleoside antibody technique (ANIP-LI). Data from earlier experiments using autoradiography (3H-thymidine) have established that the enzyme-antibody and isotopic techniques are equivalent. The LI ranged from 1 to 30 with a mean of 13 in this group of tumors. The LI could not be evaluated for 14% (3/21) of the specimens. The 3 patients with tumors not suitable for ANIP-LI had received a full course of radiotherapy and/or chemotherapy before they had entered our study. The higher the LI of the tumor, the greater the likelihood that the surgical stage would be higher than the clinical stage, most often as a result of clinically unrecognized lymph node metastasis. However, the number of tumors sampled was inadequate for a statistical trend to be identified. The potential for the LI to be useful in the formulation of improved therapeutic strategies awaits the accumulation of more data from studies currently in progress.

Carcinoma, Squamous Cell↗
PubMed1978

Eosinophilic granuloma in the head and neck: a five year review with report of an instructive case.

Head and neck symptoms occurred in 87% of patients (14 of 16) with eosinophilic granuloma seen in a 5 year period. Two patients with head and neck disease died (14% mortality). Both had concomitant pituitary disease. The underlying pathology was discovered in each instance only after a year of extensive diagnostic effort. The specific problems in diagnosis and treatment are apparent in the case report of an initially misdiagnosed patient. The following recommendations are suggested to optimize the care of such patients. Eosinophilic granuloma must be suspected in a variety of clinical settings. Radiography is the only helpful noninvasive study and definitive diagnosis depends on microscopic tissue examination. Patients with symptoms of pituitary disease pose a frustrating diagnostic problem because of the inaccessibility of the location for pathologic study. In contrast, the head and neck, ear, nose and throat are easily biopsied and comprise the region most frequently involved. A careful examination of this area is mandatory in all patients with symptoms consistent with eosinophilic granuloma intracranially or elsewhere if the disease is to be diagnosed and treated without delay.

Adolescent↗
PubMedDate not supplied

Median palatal cyst. A reminder of palate fusion.

The existence of a median palatal cyst has been questioned. Such a lesion would represent an unusual anomaly of a unique embryological process. The radiologic and pathologic criteria necessary to establish such a diagnosis are inconclusive in the ten case reports that have appeared in the English language literature. A median palatal cyst that is distinct from other palatal defects would have specific characteristics that included: 1) a true epithelial-lined cyst; 2) no salivary gland, vascular, or neural elements in the cyst wall; and 3) location in the palate at a distance sufficiently posterior to avoid confusion with structures of the nasal palatine region. We report the findings of a palate lesion excised from a 27-year-old male which by location and histology were consistent only with a median palatal cyst. These data appear to authenticate, for the first time, the median palatal cyst as a distinct pathological entity.

Adult↗
PubMedDate not supplied

Follicular adenocarcinoma of the thyroid in the maxillary sinus.

No reports of metastatic thyroid carcinoma in the maxillary, ethmoid, or sphenoid sinuses can be found in the literature. A woman with severe posterior epistaxis was examined recently. She had undergone a partial lobectomy for a thyroid tumor 16 years previously. Hemorrhagic thyroid tissue was in the maxillary sinus. The results of subsequent examinations indicated thyroid deposits in the lung and spine. The patient received radioactive iodine, 100 MCi. Her lung and spine deposits lysed, and she experienced no further epistaxis. Thyroid carcinoma's ability to metastasize to a paranasal sinus is documented here. Epistaxis after a thyroidectomy for cancer now must be considered an unusual clinical manifestation of metastatic spread, unless otherwise proved. The differential diagnosis of epistaxis must now include thyroid carcinoma metastatic to the sinonasal tract.

Adenocarcinoma↗