PubMed Health⌕ Search

Biomedical subjects

J Zák

Publications and source records attributed to J Zák.

At least 19 recordsLinked to original sources
PubMed1995

[Histomorphometry of bone in clinical practice and research].

Short overview of importance and principles of histology and histomorphometry of bone tissue patterns performed in IIIrd internal clinic since 1978 is described. Since the beginning, 736 bone biopsy patterns were taken. Generally there are two groups of indications for bone tissue investigation: differential diagnosis of osteologic or hematologic diseases, or investigational indication in a research study. Short overview of morphometric results, gained in IIIrd internal clinic is stated. Histomorphometric parameters of acromegalic and normal trabecular bone were compared and results and consequences for architecture of trabecular bone are described. No correlation between levels of somatotropin or somatomedin C and histomorphometric parameters was found out. Principles of further investigation in IIIrd internal clinic are outlined.

Acromegaly↗
PubMed1994

[Local factors in bone remodeling. II. Factors stimulating bone resorption].

In this article, author gives a surveillance of factors, locally produced in bone tissue, which stimulate bone resorption. Production of local factors in bone tissue cells is initiated by various hormones, including some systemic hormones. Some new hypothesis about relation of systemic hormones activity and local bone tissue factors production are described including hypothesis about function of estrogens on bone.

Animals↗
PubMed1992

[Changes in hypertrophy and diastolic left ventricular function during hypertension therapy].

The authors examined a group of hitherto not treated patients with primary hypertension and hypertrophy of the left ventricle. By means of echocardiography and isometric loading they investigated the effect of treatment on the left ventricular morphology and function. Despite long-term normalization of casual and loading values of the blood pressure the authors did not observe a significant regression of LV hypertrophy. The authors did not find a relationship between the casual blood pressure and weight of the left ventricle with exception of the diastolic pressure after a load. The indicators of diastolic function did not correlate with the weight of the left ventricle but with changes of the end diastolic volume and blood pressure.

Adult↗
PubMed1990

[Hormones in bone metabolism. I. Calcitropic hormones].

The review concentrates on calcitropic hormones (parathormone, calcitonin and the active metabolite of vitamin D-1,25-dihydroxyvitamin D3) and their action on bone remodeling. Attention is drawn to mechanisms of their action on the bone cell, on their manifestations in histology of osseous tissue and clinical symptomatology in pathological conditions. Attention is also drawn to the possible therapeutic application of calcitropic hormones.

Bone and Bones↗
PubMed1990

[Hormones in bone metabolism. II. Other systemic hormones].

The authors present a review on a number of systemic hormones involved in bone metabolism. At the same time they demonstrate mechanisms of their action on the cellular, tissue and skeletal level. Attention is drawn to the participation of these hormones in the pathology of bone and other organs and the necessity to protect the skeleton during their therapeutic use in other than osteologic indications.

Adrenal Cortex Hormones↗
PubMed1990

[Interrelation between static parameters of trabecular bones in acromegaly, the STH levels and the duration of the condition. Histomorphometric study].

To evaluate trabecular bone formations of active acromegalic patients the authors used the method of histomorphometry and correlated the calculated variables of the trabecular volume (V), osteoid volume (Vos), osteoid surface (Sf) and width of the osseous trabeculum (MTT) with STH levels, the patients' age and the period of the acromegalic process. No correlations were found between Vos, Sf, MTT and STH levels, age and the length of the case-history. There were negative correlations (p less than 0.05) between the trabecular volume (V) and the period of the case-history and trabecular volume (V) and the patients' age. From the results it may be concluded that STH does not influence the balance between resorption and formation of the acromegalic spongiosa in favour of formation.

Acromegaly↗
PubMed1990

[Comparative histomorphometric study of acromegalic spongy bone. Formative static parameters].

The authors used static histomorphometric parameters obtained by processing of bioptic bone specimens for comparison of normal and acromegalic spongious bone. Parameters of the bone volume (V), osteoid volume (Vos), the extent of osteoid bone surfaces (Sf) in the two groups do not differ statistically. The two groups do not differ as to age distribution. The width of bone trabeculae is greater in acromegalic bone; the difference as compared with normal bone specimens is statistically significant (p less than 0.05). The authors conclude that STH in acromegalics subjects does not stimulate osteoid production in trabecular bone to shift the balance between bone resorption and formation significantly in favour of formation. Only restructuring of trabecular acromegalic bone occurs.

Acromegaly↗
PubMed1990

Actual contribution of bronchology to the management of lung diseases.

The paper reports on bronchoscopic examinations carried out at the Department of Bronchoscopy, Clinic of Tuberculosis and Respiratory Diseases, in the period of 1977 to 1987. The applicability of individual bronchoscopic methods is evaluated. Advantages and limitations of the rigid bronchoscope and the fibrescope, techniques of removal of material for cytologic and other examinations are discussed. It is stressed that the most frequent indication for bronchoscopy is suspected bronchial carcinoma with increasing incidence.

Bronchoscopy↗
PubMed1990

[Segmental analysis of left ventricular wall mobility].

The authors present their experience with subjective and quantitative evaluation of the mobility of the left ventricular wall of the heart. The combination of computer technique and two-dimensional echocardiography makes it possible to evaluate quantitatively the function of the left ventricule of the heart by the method of segmental analysis of wall mobility. Segmental analysis has proved to be a suitable method for assessing the function of the left ventricle particularly in subjects with threshold or slightly decreased functional values. The authors use the method in studying the functional response of the left ventricle to diagnostic or therapeutic intervention. The method yields important information also on the development of left ventricular function after myocardial infarction in follow-up studies. Subjective assessment is a less demanding approach and when carried out expertly, the extent of muscular damage can satisfactorily be evaluated.

Cardiomyopathies↗
PubMed1990

[Stress echocardiography in clinical cardiology].

In their generally designed presentation the authors focus on practical problems concerning indication, different stress modalities and projections, evaluation and interpretation of findings, as well as on technical novelties and their use. Only dynamic exercise echocardiography is being discussed. Currently available knowledge is assessed in the light of the authors' own experience. Problems of evaluation and interpretation are considered to be most intricate. In the authors' opinion, many technical problems which have prevented the routine use of the method in practice will be eliminated by introducing technical novelties such as digitalization of the display with image loop. Other innovations will certainly be used to advantage and render the method less demanding and far more widespread.

Echocardiography↗
PubMed1990

[Long-term monitoring of changes in contractility of the left ventricular wall in patients with myocardial infarct].

Using two-dimensional echocardiography, the authors made a one-year investigation of left ventricular function in a group of patients after a first transmural myocardial infarction. They evaluated subjectively and quantitatively changes in the contractility and the development of the diastolic area of the left ventricle. They revealed a certain improvement of the contractility, probably as a result of the development of a collateral circulation and altered structure of the infarction focus associated with dilatation of the left ventricle by the Frank-Starling mechanism.

Adult↗
PubMed1989

[Methods of diagnostic bone biopsy and its complications].

By the end of 1986 559 assessable biopsies had been taken at 3rd internal department. The authors continue the previous study performed at the department and suggest further methods for bioptic sampling enabling sampling of larger bone cylinders. They suggest several ways of bone trepan composition adjustment. The authors discuss and compare the incidence of complications associated with bone biopsy performance. They conclude that in inpatients bone biopsy performed in short-term general anaesthesia is a safe intervention.

Biopsy↗
PubMed1989

[Methodology of diagnostic bone biopsy and its complications].

By the end of 1986 559 assessable biopsies had been taken at 3rd internal department. The authors continue the previous study performed at the department and suggest further methods for bioptic sampling enabling sampling of larger bone cylinders. They suggest several ways of bone trepan composition adjustment. The authors discuss and compare the incidence of complications associated with bone biopsy performance. They conclude that in inpatients bone biopsy performed in short-term general anaesthesia is a safe intervention.

Biopsy↗
PubMed1989

[Comparison of changes in the mobility of the left ventricular wall with coronarographic findings in patients after myocardial infarct].

The authors examined by echocardiography at rest and after exertion a group of 55 patients after a clinically confirmed first transmural infarction. They compared the echocardiographic findings with coronarographic ones. The finding at rest, as regards impaired mobility of the left ventricular wall, corresponded to the clinical finding and the coronarographic finding. By diagnosis of the extended asynergy of contraction during an isometric load it was not possible to differentiate the functional and organic cause of impaired mobility and thus to assess the extent of the coronary affection. The impaired mobility of the left ventricular wall is associated above all with the state of the blood supply rather than with the finding on the coronary artery.

Adult↗
PubMed1988

[Bone remodeling].

Explore the source record for details and available documents.

Bone Development↗