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Biomedical subjects

J Zajíc

Publications and source records attributed to J Zajíc.

11 recordsLinked to original sources
PubMed2004

[Successful indirect cardiac massage as a cause of thoracic wall instability and respiratory insufficiency].

The authors in their two cases describe unusual complication after successful indirect cardiac massage which was carried out in terrain. Both patients were then transferred to Dept. of gerontology and metabolic care. However the resuscitation was in both cases successful it caused in these two cachectic oseoporotic patients sternal and costal en block fractures. This iatrogenic trauma of thoracic wall showed up in further cause as a major problem. The patients could not have been disconnected from artificial support of ventilation and therefore their thoracic cage had to be surgically stabilized.

Aged↗
PubMed2001

Autoantibodies to asialoglycoprotein receptor in chronic hepatitis C patients.

The aim of this study was to determine the incidence of autoantibodies to asialoglycoprotein receptor (ASGPR, anti-ASGPR) in chronic hepatitis C patients and to characterize the anti-ASGPR-positive and anti-ASGPR-negative patients in more detail. A total of 79 chronic hepatitis C patients were screened for the presence anti-ASGPR by ELISA. Anti-ASGPR were detected in 11 (13.9%) patients. No significant differences were found between the anti-ASGPR-positive and anti-ASGPR-negative patients in age, alanine transaminase (ALT) activity, histological findings and response and tolerance to alpha-interferon (alpha-IFN) therapy. The male predominance in the anti-ASGPR positive group was statistically significant. It was surprising that other tested autoantibodies (antinuclear autoantibodies [ANA], smooth muscle autoantibodies [SMA], type 1 liver-kidney microsome autoantibodies [LKM-1], anti-thyroglobulin and thyroid microsome autoantibodies) and increased levels of immunoglobulins A, G and/or M were observed significantly more frequently in the anti-ASGPR-negative group.

Adolescent↗
PubMed2000

[Cross-sectional study of choice of drug therapy in the acute phase of treatment in acute myocardial infarct--part 1].

INTRODUCTION: Treatment of acute myocardial infarction is undergoing changes. In the treatment of acute myocardial infarction in particular the following proved useful: thrombolysis, administration of anti-aggregating drugs, beta-blockers and inhibitors of angiotensin converting enzyme. An decisive part is played by the interval between the onset of symptoms and the beginning of hospital treatment. OBJECTIVE: To describe treatment of patients hospitalized at intensive care units for acute myocardial infarctions. Investigate differences between faculty and other hospitals. METHOD: The authors investigated by means of questionaires in a prospective study during the first three months in 1996 all patients who were hospitalized on account of acute myocardial infarction. The investigation was implemented in seven intensive care units of faculty hospitals and in nine intensive care units of hospitals and information on diagnosis, pharmacotherapy and results of therapy were assembled. During the first 24 hours of treatment more detailed information was procured. RESULTS: Antiaggregants were used in 88%, nitrates in 77.8%, thrombolytics, beta-blockers and and ACE inhibitors in ca 30% patients. Percutaneous transluminal coronary angioplasty was used in ca 7% patients. CONCLUSIONS: The authors describe treatment of the acute stage of myocardial infarction. In faculty hospitals in 1996 thrombolysis, percutaneous transluminal coronary angioplasty, beta-blockers and nitrates by the i.v. route were used more frequently.

Adrenergic beta-Antagonists↗
PubMed1993

Intrabronchial brachytherapy using 226-radium source.

Present work reports on results of manual brachytherapy in lung cancer using intrabronchial catheter and 226-radium source. Expected dosage was 18 Gy at 1 cm from the source. This therapy was combined with external radiotherapy by 60-cobalt till the dosage about 65 Gy. 19 men were treated, the mean survival was 14.3 months. Advantages and disadvantages of the method are discussed.

Adult↗
PubMed1993

[Osteomyelitis of the ilium and traumatic rupture of a hydronephrotic right kidney imitating acute appendicitis].

The author describes two case-histories of profoundly different diseases which imitated in a similar way the symptoms of acute appendicitis. In both instances the authors had to operate under pressure of the local finding, although in the case of osteomyelitis of the ilium this diagnosis was contemplated before operation. The author draws attention to some specific features of work in developing countries.

Acute Disease↗
PubMed1992

Radio-chemotherapy in the treatment of advanced cancer.

Tests in vitro and first clinical studies proved a radiosensitizing effect of cisplatin. In our study 40 patients with advanced resistant cancer of head, neck, lungs and rectum were treated by conventional radiotherapy and cisplatin. The drug was administrated in 10 mg after each irradiation. The tumor dose varied between 30-50 Gy in 3-5 weeks, within the total dose cisplatin 150-250 mg. In more than 70% of cases remarkable retreat of tumors, in some cases even a complete regression, were observed. Adverse reactions and toxicity often associated with administration of platin were very mild, so that even patients in rather poor physical condition could have been treated. Having performed no special hydratation serious nephrotoxicity was never observed. The potentiation of radiation by cisplatin can be therefore considered a relatively harmless treatment of inoperable advanced cancers useful especially in cases where other forms of palliative treatment have been exhausted or not feasible.

Cisplatin↗
PubMed1990

[Half-body irradiation in the palliative treatment of multiple bone metastases].

The authors used as palliative analgetic treatment half-body irradiation in 13 patients with dissemination of a malignant tumour into bones. In six patients both halves of the body were irradiated. A long-term analgetic effect was observed in five patients (in one female patient more than 400 days, four patients 100-150 days), a short-term effect up to 100 days was recorded in six patients. The pain was not influenced in two patients. Mitigation of pain increased the patients' performance: according to the WHO scale in one case by 3 grades, in three patients by 2 grades, in six patients by 1 grade. The performance of three patients was not affected by irradiation. Side-effects of treatment were controlled by means of supporting treatment. They did not threaten life in any of the patients. The authors consider half-body irradiation an effective and useful analgetic treatment of multiple metastases into the bones.

Bone Neoplasms↗
PubMed1976

Reactions of oxidized lipids with protein. XIII. Interactions of polar groups of lipids with nonlipidic substances.

Contrary to fresh lipids, oxidized lipids form chloroform-insoluble, but methanol-soluble compounds with cellulose. The amount of chloroform-insoluble lipids is significantly higher in mixtures containing cellulose impregnated with albumin. Polar groups of oxidized lipids formed nonextractable compounds with protein more readily than polar groups of a monoglyceride. Compounds insoluble either in chloroform and in chloroform-methanol or methanol were formed in contact of oxidized lipids with protein, contrary to mixtures of lipids with sole cellulose. The formation of these nonextractable compounds is due both to the interaction of protein with hydroperoxides and with non-peroxidic oxidation products.

Cellulose↗