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Biomedical subjects

J de Boever

Publications and source records attributed to J de Boever.

11 recordsLinked to original sources
PubMed1985

Screening of sera and tumor extracts of cancer patients using a monoclonal antibody directed against human placental alkaline phosphatase.

A sensitive endogenous enzyme immunoassay involving an anti-human placental alkaline phosphatase (PLAP) monoclonal antibody was used in the screening of sera and tumor extracts of patients with various types of cancer. In sera of breast cancer patients an incidence of 5.2% was recorded. This value rose to 43% when tumor extracts were analyzed. For lung and bronchial cancers we found 11.2% seropositive patients. On several occasions a good correlation was observed between the PLAP determinations and the histopathological staging of tumor tissue.

Adult↗
PubMed1985

The occurrence of human placental alkaline phosphatase (PLAP) in extracts of normal, benign and malignant tissues of the female genital tract.

In addition to its presence in extracts of carcinomatous tissues from the vulva, endometrium and ovary, PLAP can also be found in tissue extracts of benign conditions of the endometrium and myometrium. We detected slightly elevated levels of PLAP in patients with myoma, raised levels in 2/2 patients with endometrial polyps and high values in 2/2 patients with glandulocystic hyperplasia. Moreover, normal endometrium and fragments of normal Fallopian tube also contained fairly high amounts of endogenous PLAP. These results have important implications with regard to the possible use of PLAP as a tumour marker or of anti-PLAP monoclonal antibodies in radioimmunolocalization or radioimmunotherapy.

Adolescent↗
PubMed1983

Revascularization of gingival autografts placed on different receptor beds. A fluoroangiographic study.

The revascularization of gingival autografts, placed either on fenestrated periosteum or on non-fenestrated periosteum, has been compared by means of 12 fluorescein angiographs, taken 8, 10 and 12 days postoperatively on 12 patients, 18-32 years of age. The grafts placed on periosteum (P-zone) showed a mean increase of fluorescence of 10.6% between the 8th and 10th day and of 19.4% between the 10th and 12th day. At that time the circulatory system in the graft seemed to be established for 97.7%. The grafts placed on fenestrated periosteum (B-zone) showed a mean increase of fluorescence of 13.2% between the 8th and the 10th day and of 13.5% between the 10th and 12th day. The revascularization reached 96.1% at that time. Between both groups no statistically significant difference has been found. It can be concluded that a periosteal receptor side is not a prerequisite for the formation of an even circulatory pattern in gingival autografts.

Adolescent↗
PubMed1980

[Symptomatology of pain-dysfunction of the temporomandibular joint].

Symptomatology of pain-dysfunction in the temporomandibular joints. The symptomatology of 135 patients treated for pain-dysfunction syndrome (PDS) of the temporomandibular joints has been described. They were divided into five dysfunction groups according to the clinical dysfunction-index of Helkimo (1976). 75,3% of the patients were females, especially between 25-40 years of age. Most of the patients fell into the dysfunction II and III group. 20,0% of the patients waited 0-3 months between the onset of the pain and the first demand for treatment, 41,7% waited 0-6 months. 18.0% waited even longer than 25 months to consult the dentist. Almost 40% had psychological problems. Bruxism was present in 66% and joint noises have been found in 92,0%. A deviation in the openings movement occured in 55%, a reduction of the lateral movement has been observed in 38%. No correlation could be found between the dysfunction index and the number of occluding pairs of molars (r = .03) or premolars and molars combined (r = .20). This was also the case for all other anamnestic and occlusal parameters except for the occurrence of premature contacts on the balancing side. The fact is stressed that the etiology of PDS is multifactorial.

Adolescent↗