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J de La Tour

Publications and source records attributed to J de La Tour.

At least 19 recordsLinked to original sources
PubMed1984

[Effect of 5-thioglucose on external pancreatic secretion in rats. Comparison with 2-deoxyglucose].

The aim of this study was to compare the stimulation of the external pancreatic secretion induced in rats by two glucose analogs: 5-thio-glucose (5-TG) and 2-deoxy-glucose (2-DG). In rats with an acute pancreatic fistula, 5-TG and 2-DG induced a dose-related increase in outputs of sodium (reflecting the volume), bicarbonate and total protein of the pancreatic juice. The efficacy of both drugs was not significantly different. Maximal responses were obtained with 75 mg/kg 5-TG and 225 mg/kg 2-DG and were approximately 3.5 x (sodium), 5 x (bicarbonate) and 8.5 x (protein) the basal level. Dose-response curves to 5-TG were shifted to the left with respect to 2-DG. The DE50 was approximately 25 mg/kg for 5-TG and 60 mg/kg for 2-DG. The molar potency ratio was 2.5 x, 3.1 x and 3.3 x in favor of 5-TG, for sodium, bicarbonate and protein respectively. The potency, but not the efficacy, of 5-TG is thus greater than that of 2-DG in stimulating external pancreatic secretion.

Animals↗
PubMed1978

Methadone blockade of 2-deoxyglucose-induced pancreatic secretion in the rat.

The effects of methadone on pancreatic exocrine secretions in the rat were tested under basal conditions and after hormonal stimulation by secretin and caerulein or after stimulation of the differentially acting cholinergic agents acetylcholine, 2-deoxyglucose, and electrical stimulation of the vagus. Methadone had no effect on basal hydroelectrolytic secretion. It decreased basal enzyme secretion very slightly under our experimental conditions. The stimulatory effects of 75 mg of 2-deoxyglucose per kg were completely blocked by methadone at 5 mg per kg and this blockade was reversed by nalorphine at 6 to 9 mg per kg. It was found that there are doses of methadone (100 microgram) which block 2-deoxyglucose effects when injected into brain ventricles but are ineffective when systemically introduced. The effects of secretin, caerulein, acetylcholine, and electrical stimulation of the vagus were not depressed by methadone. These results strongly suggest that the methadone blockade of 2-deoxyglucose effects occurs at a central level and is mediated by narcotic drug receptors.

Acetylcholine↗
PubMed1977

Effects of chronic ethanol consumption on pancreatic response to central vagal stimulation by 2-deoxy-D-glucose in the rat.

Male Wistar rats, fed a standard normal laboratory diet, drank ad libitum a 20% ethanol solution for 3 months. Basal and 2-deoxy-D-glucose (2DG) stimulated pancreatic secretion were measured. Basal secretion of sodium (-30%, p less than 0.001), bicarbonate (-35%, p less than 0.001) and total protein (-35%, p less than 0.001) were depressed in alcoholic versus control rats. Pancreatic response was identical in both groups with the smaller dose of 2DG, dose related in controls, and identical for both doses in alcohol-fed rats. The response was thus significantly smaller in alcohol-fed rats than in controls for the larger dose of 2DG (p less than 0.01). Pancreatic concentration and contents of amylase, trypsinogen, chymotrypsinogen and lipase were all decreased in alcoholic versus control rats (40-60%, p less than 0.001). These results are consistent with the hypothesis of functional modifications in pancreatic cholinergic innervation in alcohol-fed rats.

Amylases↗
PubMed1976

[Pancreatic secretion in rats. A comparative study of basal and stimulated secretions in acute and chronic fistula conditions (author's transl)].

Two types of pancreatic fistulas were directly compared in Wistar rats, to define more accurately the differences between collecting pancreatic juice under anesthesia (acute fistula) and in awake restrained animals (chronic fistula). Basal outputs of water, bicarbonate and total protein were about then times larger in chronic than in acute animals; they could be larger than the maximal secretory rate in anaesthetized rats. As a corollary, the chronic preparation was less sensitive to ecbolic and hydrelatic stimulations, with respect to basal levels. It is concluded that chronic fistula rats display a highly stimulated state of pancreatic secretion, probably due to the potentiation of several neurohumoral factors. Whatever this stimulation originates from, it renders the model less suitable for studies on ancreatic stimulating agents. On the contrary, anaesthetized rats displayed a low secretion more responsive to stimulating agents.

Acetylcholine↗
PubMedDate not supplied

[Aggravation of acute galactosamine hepatitis by a sodic bicarbonated water in rats (author's transl)].

1. Acute galactosamine (Gal) hepatitis was induced in rats drinking ad libitum either sodic bicarbonated water of Vichy Grande Grille (GG) or ordinary tap water (OH2). Two series of experiments were performed. 2. In the first series, Gal-induced hepatitis was moderate. Twenty four hours after IP Gal injection, GG treated rats had relative to OH2 treated rats a decrease of bile flow and BSP excretion, and an increase of serum transaminase and bilirubin. Seven days after Gal the liver had returned to normal except for an increase in biliary bilirubin and liver total lipids. 3. In the second series, Gal-induced hepatitis was severe. Twenty four hours after galactosamine administration, an increase in mortality after anesthesia was found in Gal/GG rats. An increase of liver size and total hepatic lipids was also observed, while bile secretion, BSP excretion, cyt P 450 and ARN decreased in Gal/GG rats. Steatosis and inflammatory reactions were more important in Gal/GG than in Gal/OH2 rats. Most parameters came back to their normal levels in two days in Gal/OH2 rats, while 7 days were generally necessary in Gal/GG treated animals. Hepatic DNA kept increasing in Gal/GG animals and was still higher after 7 days, maybe due to a greater inflammatory reaction in the liver, maybe following a stimulated hepatocyte regenerative response. 4. These results indicate that GG water is not an inoffensive salt solution.

Animals↗