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J de la Cuadra

Publications and source records attributed to J de la Cuadra.

At least 19 recordsLinked to original sources
PubMed1994

Assessment of the wheal size and skin blood flow of the erythema induced by histamine and its modification with cetirizine and ebastine: a crossover, double-blind study.

In order to assess the antihistaminic power of cetirizine and ebastine, we designed a randomized, double-blind, crossover study, measuring their capacity to modify skin blood flow induced by a histamine prick test. The vasomotor response was compared using a laser Doppler flowmeter. Two hours after intake of the antihistaminic drug, there were significant differences between both drugs: at 4 h, the antihistaminic effect of cetirizine persists, whereas ebastine only showed moderate activity. The reduction of the cutaneous blood flow values (CBFV) showed good activity in both groups, but cetirizine was more potent and showed faster activity than ebastine.

Adolescent↗
PubMed1993

[Cutaneous sensitivity to mercury and its compounds].

We present the results of a study, spread over a 12-year period, concerning the frequency of skin sensitization to mercury and some of its compounds in a Spanish community. Among 2,592 subjects suspected of allergic contact dermatitis, 3.5 p. 100 had a positive test to metallic mercury 0.5 p. 100 in petroleum jelly. The pertinence of the test was regarded as "present" or "fast" in 63.9 p. 100 of the cases, and the dermatitis was found to be related to antiseptic Mercurochrome (merbromin) solutions, cosmetics containing ammoniated mercury and inhalation of mercury after breaking of thermometers. We consider that in children metallic mercury should be tested at a concentration not exceeding 0.1 p. 100. Among 2,154 subjects suspected of allergic contact dermatitis, 109 (5 p. 100) had a positive test to thiomersal 0.1 p. 100 in petroleum jelly. The pertinence of the test was regarded as "present" or "past" in 53.8 p. 100 of the cases, and the dermatitis was attributed to antiseptic solutions, eye drops, cosmetics and shoes. There was no cross-reaction between thiomersal and mercury, except in those cases where mercury chloride was the allergic determinant responsible for sensitization to thiomersal (39.4 p. 100 of the cases). Fifteen patients consulted for photoallergy to piroxicam, and all had a positive test to thiosalicylic acid which is the compound most frequently responsible for sensitization to thiomersal (51.6 p. 100 of our cases) and for cross-reaction between thiomersal and piroxicam.

Dermatitis, Allergic Contact↗
PubMed1991

Occupational contact dermatitis from rhodium and cobalt.

We report a case of occupational allergic contact dermatitis from rhodium sulphate and cobalt chloride in a 29-year-old woman working in a goldsmith's workshop. The relevance and source of sensitization to these metals in our patient is described, and the literature on the subject reviewed.

Adult↗
PubMed1986

[A new test for evaluating the von Willebrand factor: collagen-induced agglutination of fixed thrombocytes].

In primary hemostasis von Willebrand factor (vWf) promotes the adhesion of platelets to subendothelial structures of the damaged blood vessel. A new test is described which measures the collagen binding affinity of vWf. Activities of vWf in plasmas of 51 patients were measured with either collagen (ColCof) or ristocetin (RCof). Regression-analysis showed a good correlation of both activities (r = 0.924). In a second group of 21 patients with a variant of von Willebrand's disease, ColCof activity was generally higher than RCof activity.

Collagen↗