PubMed Health⌕ Search

Biomedical subjects

J van Heerden

Publications and source records attributed to J van Heerden.

At least 37 records · Page 2Linked to original sources
PubMed1993

Besnoitiosis in a horse.

Besnoitiosis was confirmed in a pony which presented with inspiratory dyspnoea, scleroderma and ventral oedema. Numerous cysts were visible in the sclerae. Histological examination of the skin confirmed the presence of numerous cysts. The parasite could not be transmitted by subcutaneous injection of homogenised skin from the infected horse to rabbits and a horse. Ultrastructural morphology of the crescent-shaped bradyzoites was not compatable with Besnoitia besnoiti or B. jellisoni and it is proposed that the infection was caused by B. bennetti.

Animals↗
PubMed1992

Clinical and biochemistry findings, and parathyroid hormone concentrations in three horses with secondary hyperparathyroidism.

Three cases of horses with nutritional secondary hyperparathyroidism (NSH) are described. The horses showed typical thickening of the maxillae and mandibular bones with or without lameness. Laboratory findings included elevated concentrations of parathyroid hormone (carboxy-terminal and mid-molecule fractions), alkaline phosphatase and an increase in the fractional excretion rate of serum inorganic phosphorus.

Animals↗
PubMed1992

Parathyroid carcinoma: clinical and pathologic features in 43 patients.

Parathyroid carcinoma accounts for 0.5 to 5% of all cases of hyperparathyroidism. We reviewed the clinical, surgical, and pathologic features observed in all patients with parathyroid carcinoma evaluated at the Mayo Clinic from 1920 through 1991. Forty-three patients (22 women, 21 men; mean age, 54 yrs, range 29-72) were identified, including 2 with familial hyperparathyroidism. Information on initial presentation was available in 40 patients: 15 (38%) presented with polydipsia or polyuria, 11 (27%) with myalgias or arthralgias, 7 (17%) with weight loss, and 4 (10%) with nephrolithiasis; 3 patients (7%) were asymptomatic at presentation. Of 31 patients in whom the initial neck examination was recorded, 14 (45%) had a palpable neck mass. The mean serum calcium and serum phosphorus levels were 14.6 mg/dl and 2.3 mg/dl, respectively. Parathyroid hormone levels were elevated in 21 of 21 patients (mean elevation, 10.2 times upper limit of normal). Complications included nephrolithiasis in 14 of 25 patients (56%), bone disease in 20 of 22 patients (91%) and both in 8 of 15 patients (53%). All patients underwent primary surgical resection of parathyroid carcinoma. Twenty-six of 43 patients (60%) required a second operation with 18 patients requiring multiple re-explorations. At the second operation, residual tumor was found in the neck (68%), mediastinum (16%), or both (12%). Six patients received radiation therapy to the neck (5 patients) or bones (1 patient) for recurrent or metastatic disease. Of these, 1 patient appeared cured of parathyroid carcinoma by radiation therapy 11 years after documented tumor invasion of his trachea. Repeated excision of tumor recurrences was an effective means of controlling hypercalcemia in these patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Academic Medical Centers↗
PubMed1991

A preliminary investigation into the immobilising potential of a tiletamine/zolazepam mixture, metomidate, a metomidate and azaperone combination and medetomidine in ostriches (Struthio camelus).

Ostrich chicks (n = 34) were successfully immobilised with intramuscular injections of a tiletamine/zolazepam mixture at dosages of 5, 10, 15 and 20 mg kg-1; with metomidate at dosages of 15 and 20 mg kg-1 and with a metomidate/azaperone combination at respectively 20 and 6.6 mg kg-1, and 10 and 3.3 mg kg-1. Unsatisfactory immobilisation with violent body movements and self traumatisation were observed in an adult ostrich after the intramuscular administration of a tiletamine/zolezepam mixture. Anaesthesia was achieved by the administration of metomidate in combination with azaperone. Medetomidine administered at a dosage rate of 0.1 mg kg-1 did not result in immobilisation of ostrich chicks (n = 4). Findings in ostrich chicks should not necessarily be extrapolated to adult birds.

Animals↗
PubMed1990

Liposarcoma of bone marrow origin in a kudu (Tragelaphus strepsiceros).

A primary intraosseous liposarcoma in a kudu (Tragelaphus strepsiceros), is reported. The lesion had a multilocular radiographic appearance and caused fracture of a metacarpus of the right front leg. Microscopically the lesion consisted of a lobular proliferation of lipoblasts of varying maturity. This is the first description of an intraosseous liposarcoma in a nondomesticated animal.

Animals↗
PubMed1990

Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis.

Although the etiology of pouchitis after ileal pouch-anal anastomosis (IPAA) is unknown, its manifestations resemble those of nonspecific inflammatory bowel disease, including, anecdotally, the apparent ability to evoke extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD). Our aim was to determine in what manner pouchitis and EIMs were associated. The computerized records of 819 consecutive patients who underwent IPAA between January 1981 and December 1988 were reviewed. Eighty-five patients were excluded (because of incomplete follow-up, death, or permanent ileostomy). Follow-up of the remaining 734 patients was complete (mean, 41 months). The mean age was 32 years and the ratio of men to women was 1:1. Ileal pouch-anal anastomosis was performed for chronic ulcerative colitis in 91% of patients and for familial adenomatous polyposis in 9%. Pouchitis occurred in 31% of chronic ulcerative colitis patients and 6% of familial adenomatous polyposis patients (p less than 0.01). The mean time to first occurrence was 17 months. Pouchitis recurred in 61% of patients at risk. Patients with preoperative and postoperative EIMs had significantly higher rates of pouchitis than did patients without EIMs (39% preoperative EIMs versus 26% with no EIMs, p less than 0.001; 53% postoperative EIMs versus 25% with no EIMs, p less than 0.001). Of patients with pouchitis in whom EIMs resolved after IPAA but then recurred (n = 12), EIMs recurred when pouchitis occurred and abated when pouchitis was treated in seven patients. We concluded that pouchitis occurred frequently after IPAA and that patients with EIMs were at higher risk of developing pouchitis than were patients who never had EIMs. Furthermore some patients experienced a temporal relationship between flares of EIMs and pouchitis. These results imply that pouchitis may be a novel manifestation of inflammatory bowel disease persisting after operation.

Adult↗
PubMed1988

Insulinoma. The value of intraoperative ultrasonography.

After establishing the diagnosis of an insulinoma, most surgeons prefer preoperative localization. Selective arteriography has long remained the gold standard for this purpose, but its use has been met with variable success. Despite various attempts at localization, insulinomas remain undetected in 10% to 20% of patients, and there may be a postoperative complication rate of at least 10% to 25%. To review the results and surgical implications of current localization techniques, 36 adult patients who were surgically treated for insulinomas at the Mayo Clinic, Rochester, Minn, from July 1982 through June 1987 were studied. The sensitivities of tumor localization using arteriography, computed tomography, and preoperative and intraoperative ultrasonography were 53%, 36%, 59%, and 90%, respectively. A subset of 29 patients underwent intraoperative ultrasonography, and all of these patients' insulinomas were identified with a combination of this technique and intraoperative palpation, with nonpalpable tumors being imaged in four patients. In 18 patients (62%), information obtained from the images appeared to influence the surgical management. While there is no substitute for exploration by an experienced surgeon, exploration appears to be enhanced by the addition of intraoperative ultrasonography, particularly during reoperation.

Adenoma, Islet Cell↗
PubMed1987

An investigation into the clinical pathological changes and serological response in horses experimentally infected with Babesia equi and Babesia caballi.

Serologically negative horses, as determined with the indirect fluorescent antibody test (IFA), were infected with Babesia equi and 60 days later with Babesia caballi. The only clinical signs of disease observed in these animals were a febrile reaction and slight icterus. Haematological changes included a drop in haematocrit and haemoglobin concentration, as well as lowered platelet counts. The serum concentrations of albumin, iron and phosphorus were lowered. Mildly elevated serum bilirubin and fibrinogen concentrations were observed. Antibody titres were determined with the IFA and complement fixation (CF) tests. Antibodies to B. equi were first detected between Days 10-19 and 12-38 with the IFA and CF test, respectively, while the corresponding IFA periods for B. caballi were 6-8 days after infection. The parasitaemia of both B. equi and B. caballi infections never reached the 1% level.

Animals↗
PubMed1985

Blood chemical parameters in free-living white rhinoceros Ceratotherium simum.

Serum concentrations of sodium, potassium, chloride, total protein, albumin, aspartate transaminase, creatine kinase, lactate dehydrogenase, gamma-glutamyltranspeptidase, alkaline phosphatase and alanine transaminase were determined in free-living white rhinoceroses Ceratotherium simum (n = 20). Single serum cortisol (n = 20), oestradiol-17 Beta (n = 14) and progesterone (n = 14) concentrations are also presented. Low serum sodium (129.6 +/- 4.2 mmol/l) chloride (94.2 +/- 3.05 mmol/l) and albumin (26.1 +/- 3.71 mmol/l) as well as high globulin (alpha 1, alpha 2, beta and gamma) concentrations were outstanding features.

Animals↗
PubMed1985

Blood chemical parameters in shot Cape Mountain Zebra Equus zebra zebra.

Serum levels of cortisol, sodium, potassium, chloride, urea, creatinine, total protein, albumin, phosphorus, aspartate transaminase, creatine kinase, lactate dehydrogenase, iron, total magnesium, total calcium, alkaline phosphatase, alanine transaminase and gamma-glutamyltranspeptidase were determined in 11 short Cape Mountain Zebra Equus zebra zebra.

Animals↗
PubMed1982

A retrospective study on 120 natural cases of canine ehrlichiosis.

In a retrospective study on 120 natural cases of canine ehrlichiosis, it was found that cases were presented in all months of the year. The disease was diagnosed in 26 different breeds amongst which the German Shepherd was the best represented. Of the different breeds of dog, German Shepherds showed the highest incidence of chronic cases as well as the highest mortality rate. In a randomly selected sample of 50 dogs, the clinical signs of canine ehrlichiosis were found to be mainly non-specific. The terms acute, subacute and chronic are proposed to describe the different stages of disease. The total white cell count was found to be of prognostic value. Treatment with either doxycycline or oxytetracycline was found to be effective in most of the cases. Blood transfusion was the most important method of supportive therapy.

Animals↗
PubMed1980

The treatment of Filaroides osleri infestation with albendazole.

A dog infested with Filaroides osleri was dosed with albendazole at 9,5 mg/kg every day for 55 days. Clinical signs of disease disappeared after 30 days but a few nodules were still present in the left bronchus 373 days after the onset of treatment. The anthelmintic caused an increase in lymphocyte and decrease in neutrophil count.

Albendazole↗
PubMed1979

Carcinoma of the oesophagus.

A survey of carcinoma of the oesophagus at Kalafong Hospital revealed a greater incidence of the disease in males, being highest in the age group 50 - 59 years, with the middle third of the oesophagus the most prevalent site and with oesophagotracheal or oesophagobronchial fistulae a common complication.

Adolescent↗