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Biomedical subjects

J van Loosen

Publications and source records attributed to J van Loosen.

9 recordsLinked to original sources

A cephalometric analysis of nasal septal growth.

In a study using lateral cranial radiographs of 454 males and 475 females (age 0-20 years) the anterior nasal spine-nasion (ANS-N) and ANS-posterior nasal spine (ANS-PNS) distance were measured and related to age and gender. The development of both dimensions is best described by negative exponential functions. ANS-PNS distance to the age of 5 and the ANS-N distance to the age of 2, develop linearly without gender difference. After this, deceleration, statistically more significant in females (P < 0.01, ANCOVA non-linear regression analysis) occurs for both parameters. Although a study of this type does not have maximal sensitivity, no significant calendar-age-related 'growth spurts' were detected.

Adolescent↗

Differentiation of proliferating from resting cartilage in human fetal nasal septum by magnetic resonance imaging.

Magnetic Resonance Imaging (MRI) has been used for the characterization of human fetal nasal septa. The images were made from fixed fetal heads from spontaneous abortions of different gestational age. The "in-plane" resolution of the images (at a pixel size of 312 x 312 microns2) allowed a detailed anatomical analysis of the midfacial structures of the fetal heads. In T2-weighted midsagittal sections a low signal intensity region of the septal cartilage could be seen. This part was shown to consist of immature proliferating cartilage by histochemical methods and contrasted to mature resting tissue at the rim of the septum. Direct comparison of the MR images with histological sections demonstrated the potential of MRI in pre- and postoperative evaluation of patients requiring surgical reconstruction of either traumatic or congenital defects of the face.

Cell Division↗

The nasal septal cartilage in the newborn.

The largest part of the nasal septum in young children is cartilaginous. It was established that the cartilaginous septum shows a specific pattern of regional differences in thickness and histologic differentiation. The possible meaning of those phenomenons for growth and support are discussed.

Cartilage↗