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Biomedical subjects

J van Rossum

Publications and source records attributed to J van Rossum.

10 recordsLinked to original sources
PubMed1985

Determination of cotinine in biological fluids by capillary gas chromatography-mass spectrometry-selected-ion monitoring.

A sensitive and selective method for the determination of cotinine in plasma and urine is presented. Quantitation is effected by capillary gas chromatography-mass spectrometry after liquid--liquid extraction of 0.25-1 ml of biological specimens with a trideuterated cotinine internal standard. The procedure is linear and has acceptable precision over the range of concentrations encountered in pharmacokinetic studies of nicotine or cotinine. The suitability of the assay is shown by a number of plasma concentration--time curves after a single oral or intravenous administration of cotinine to a human volunteer and after multiple-dose intravenous administration of nicotine.

Body Fluids↗
PubMed1984

Disulfiram polyneuropathy.

Disulfiram in generally accepted maintenance doses in alcoholism may produce a rather severe polyneuropathy. In addition to the 39 literature cases, 5 personal patients were examined. Detailed clinical findings are given and the frequent permanent sequelae are emphasized. In 2 patients sural nerve biopsies were studied (including electromicroscopical examination) revealing a primary axonal lesion. In the treatment of alcohol addiction one should be aware of this complication.

Adult↗
PubMed1980

Management in the carpal tunnel syndrome: clinical and electromyographical follow-up in 62 patients.

Sixty-two patients suffering from carpal tunnel syndrome (CTS) were followed for an average period of 36 months, and clinical and electromyographical assessments were carried out repeatedly before and after treatment. Treatment was either conservative (25 patients) or surgical (37 patients). The use of repeated electromyographical examinations to supplement the clinical data proved to reveal more objective information on which to determine the choice of therapy. This type of management leads to the choice of medical treatment for patients showing a decrease in an initially prolonged distal motor latency time of the median nerve, whereas surgery may be preferred in patients showing progressively increasing latency times. In this way, a valuable guideline, i.e. the correlation between distal latency times and natural course, can provide a more objective basis for management of CTS patients. The similar final outcome in both groups in our opinion favours the proposed management.

Carpal Tunnel Syndrome↗
PubMed1979

Facial palsy as the initial symptom of a lymphoreticular malignancy. Case report.

In this case report an adult patient is described who initially manifested a peripheral facial palsy mimicking 'Bell's palsy', which later on appeared to be the first manifestation of a lymphoreticular malignancy. Cranial nerve involvement appears to be very rare as a first symptom of malignant systemic disease. The importance of additional investigations including lumbar puncture and CSF cytology in cases of facial nerve palsy is stressed.

Cranial Nerve Neoplasms↗
PubMed1978

Tennis elbow--a radial tunnel syndrome?

The hypothesis that the chronic tennis-elbow syndrome is caused by an entrapment neuropathy of the radial nerve (Roles and Maudsley 1972) was put to the test prospectively in ten patients. Detailed orthopaedic, neurological and neurophysiological examinations did not reveal any involvement of the radial nerve. It is concluded that this syndrome cannot be explained by an entrapment neuropathy.

Adult↗
PubMed1975

Localization of central noradrenergic mechanisms in cardiovascular regulation in rats.

1. Various drugs were injected stereotactically into the brain of anaesthetized rats. 2. Noradrenaline injected into the area of the nucleus of the tractus solitarius in the lower brain stem or into the far anterior hypothalamus/pre-optic region induced a fall in blood pressure and heart rate related to the administered dose. 3. When injected into the anterior hypothalamus/pre-optic region, clonidine and alpha-methylnoradrenaline induced a long-lasting decrease in blood pressure and heart rate.

Animals↗