Patch testing with a dilution series of nickel sulfate.
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Biomedical subjects
Publications and source records attributed to J von Mayenburg.
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This is a report on the therapeutic experience gained in 10 patients treated with a urea ointment combination alternatively with and without 1% hydrocortisone. Four of the ten patients successfully completed the therapy as planned after 12 months. The reasons for therapy drop-outs will be discussed. Based on our observations, the above-mentioned therapeutic regimen can be recommended in conjunction with all treatment measures for longer term therapy of neurodermatitis if the patients are well instructed.
27 patients with positive D3 reactions on patch testing to 3 mercury screening allergens were patch tested with 13 mercury patch test preparations, 6 inorganic and 7 organic, and amalgam 20% pet. The 13 patients (all women) showing positive reactions to 20% amalgam were then patch tested to reducing concentrations. 2 patients reacted down to 1%, 4 down to 2%, 4 down to 5%, 2 down to 10% and 1 only to 20%, a total of 10 of the 13 patients therefore reacting to the 5% concentration of amalgam. The appropriate patch test concentration of amalgam is discussed and the clinical significance and female preponderance of amalgam reactivity suggested as being worthy of further investigation.
Repeated intracutaneous injections of alpha-MSH failed to stimulate local pigmentation in healthy persons. Only additional application of UV irradiation resulted in a distinct brown discoloration of the skin at the site of injection.
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90 patients with "hayfever" - that means pollenallergic diseases of the respiration tract and the eyes - were treated in spring 1974 and 1975 with a tyrosinabsorbed grass and rye depot extract with three injections before the pollen-season. Only 16 patients had an isolated grass-rye-pollen-allergy in skin test, all the other patients had additional extrinsic allergies. These results were proved by RAST. One third of the patients had bad side-effects (27 out of 90) during the treatment. 17 patients showed general reactions and ten patients very strong local reactions. We think that these side-effects were caused by contact with antigens (hairs of animals, foods, flowers of trees) during therapy and acute or chronic infections. The results of therapy were asked by a questionnaire one year after the series of injections, there were 37 improved, 32 unchanged and/or worsened in pollen-season after treatment. Nevertheless the results encouraged to continue this treatment with the grass-rye-pollen-extract. It could be used as an "initial treatment" in pollinosis patients with a wide spread allergy just before the beginning of the pollen-season. It is necessary to fullfill all procedures of precaution which are in use in hyposensitizationtherapy to prevent stronger side-effects.
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