Biomedical subjects

Jörgen Bengtsson

Publications and source records attributed to Jörgen Bengtsson.

11 recordsLinked to original sources

PubMed2007

Diffractive optical elements designed for highly precise far-field generation in the presence of artifacts typical for pixelated spatial light modulators.

Diffractive optical elements (DOEs) realized by spatial light modulators (SLMs) often have features that distinguish them from most conventional, static DOEs: strong coupling between phase and amplitude modulation, a modulation versus steering parameter characteristic that may not be precisely known (and may vary with, e.g., temperature), and deadspace effects and interpixel cross talk. For an optimal function of the DOE, e.g. as a multiple-beam splitter, the DOE design must account for these artifacts. We present an iterative design method in which the optimal setting of each SLM pixel is carefully chosen by considering the SLM artifacts and the design targets. For instance, the deadspace-interpixel effects are modeled by dividing the pixel to be optimized, and its nearest neighbors, into a number of subareas, each with its unique response and far-field contribution. Besides the customary intensity control, the design targets can also include phase control of the optical field in one or more of the beams in the beam splitter. We show how this can be used to cancel a strong unwanted zeroth-order beam, which results from using a slightly incorrect modulation characteristic for the SLM, by purposely sending a beam in the same direction but with the opposite phase. All the designs have been implemented on the 256 x 256 central pixels of a reflective liquid crystal on silicon SLM with a selected input polarization state and a direction of transmission axis of the output polarizer such that for the available different pixel settings a phase modulation of ~2pi rad could be obtained, accompanied by an intensity modulation depth as high as >95%.

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PubMed2006

Three-level phase modulator based on orthoconic antiferroelectric liquid crystals.

Surface-stabilized orthoconic antiferroelectric liquid crystals (OAFLCs) have a director tilt of theta = 45 degrees and are, with no field applied, negatively uniaxial with the optic axis perpendicular to the cell substrates. We demonstrate that OAFLCs can be utilized to achieve lossless phase modulation with three almost equidistant phase levels. This turns out to be true also for polymer-stabilized OAFLCs, where the polymer network increases the switching speed of the device without affecting the phase modulation appreciably.

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PubMed2006

Diffraction-based determination of the phase modulation for general spatial light modulators.

We describe a characterization method based on diffraction for obtaining the phase response of spatial light modulators (SLMs), which in general exhibit both amplitude and phase modulation. Compared with the conventional interferometer-based approach, the method is characterized by a simple setup that enables in situ measurements, allows for substantial mechanical vibration, and permits the use of a light source with a fairly low temporal coherence. The phase determination is possible even for a SLM with a full amplitude modulation depth, i.e., even if there are nulls in the amplitude transmission characteristic of the SLM. The method successfully determines phase modulation values in the full 2pi rad range with high accuracy. The experimental work includes comparisons with interferometer measurements as well as a SLM characterization with a light-emitting diode (LED).

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PubMed2006

Analog low-loss full-range phase modulation by utilizing a V-shaped switched ferroelectric liquid-crystal cell in reflective mode.

We have studied the analog (V-shaped switching) mode in ferroelectric liquid crystals in reflective mode for analog phase modulation applications. We have found that several combinations of cell thicknesses and input polarization states exist for which near-lossless analog phase modulation with a range of approximately 2pi rad is obtained, and we demonstrate one such combination experimentally. Despite a slight deviation from the ideal conditions, e.g., the tilt angle was 38 degrees instead of the desired 45 degrees , virtually pure 1.6pi rad phase modulation was obtained; the measured values agree very well with our numerical simulations of the real device.

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PubMed2006

Near-lossless continuous phase modulation using the analog switching mode (V-shaped switching) in ferroelectric liquid crystals.

The analog switching mode in ferroelectric liquid crystals, sometimes referred to as 'V-shaped switching,' has, thanks to its submillisecond switching capability, attracted much interest for future fast electro-optic displays where it is to be used for amplitude modulation. We have studied this mode for analog phase-only modulation. As V-shaped switching is based on a conical motion of the index ellipsoid this presents a challenging problem since both the orientation of the slow and fast axes, as well as the amount of birefringence varies in the switching process. We show theoretically, partly by means of Poincaré sphere analysis, that it is in fact possible to obtain near-lossless analog phase modulation between zero and pi radians in an ideal V-shaped switching cell through careful tuning of the polarization state of the input light. Furthermore, we were able to demonstrate this experimentally in a fabricated cell. Although this cell deviated slightly from the ideal conditions, e.g., the tilt cone half-angle was 38 degrees instead of the desired 45 degrees , we still obtained a continuous phase modulation between zero and 0.78pi rad with less than 2% modulation of the amplitude; the measured values agree very well with our numerical simulations of the real device.

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PubMed2006

Replication of continuous-profiled micro-optical elements for silicon integration.

A novel scheme for the integration of diffractive optical elements onto silicon is presented. The processing is made in reverse order, meaning that the process of structuring the optical elements on the wafer precedes the silicon microstructuring. The first processing step on the wafer is the hot embossing of the optical microstructures into an amorphous fluorocarbon polymer spin coated on the wafer. The cured polymer forms a highly stable material with excellent optical properties. The remaining silicon processing is thus performed with the diffractive optical elements already in place. Two different diffractive structures were used in the development of the method-a (Fresnel) lens with a rather low f-number and a diffractive element producing a fan-out of a large number of paraxial beams.

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PubMed2006

Efficient numerical representation of the optical field for the propagation of partially coherent radiation with a specified spatial and temporal coherence function.

We propose a method to narrow the gap between the rigorous methods for the propagation of partially coherent light, which require excessive computational capacity, and the numerical methods used in practical engineering applications, where it is not clear how to handle spatial and temporal coherence in a statistically correct manner. As is the case for the latter methods, the numerical method described can deal with fields with a large spatial and temporal extent, which is necessary in practical applications such as laser fusion or optical lithography. However, the method also takes a few steps toward a more rigorous, yet efficient, representation of the optical field, which depends on detailed specified coherence properties of the radiation. The described method uses a set of independent monochromatic fields at different oscillation frequencies. The frequencies are chosen such that the statistical properties of the integrated intensity closely resemble those from a full-time trace treatment. Finally, we demonstrate the capabilities and limitations of the method with a few numerical examples of the propagation of a large field with a specified spatial and temporal coherence.

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PubMed2005

On-line desalting and determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in microdialysis and plasma samples using column switching and liquid chromatography/tandem mass spectrometry.

A sensitive and reproducible method for the determination of morphine and the metabolites morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) was developed. The method was validated for perfusion fluid used in microdialysis as well as for sheep and human plasma. A C18 guard column was used to desalt the samples before analytical separation on a ZIC HILIC (hydrophilic interaction chromatography) column and detection with tandem mass spectrometry (MS/MS). The mobile phases were 0.05% trifluoroacetic acid (TFA) for desalting and acetonitrile/5 mM ammonium acetate (70:30) for separation. Microdialysis samples (5 microL) were directly injected onto the system. The lower limits of quantification (LLOQ) for morphine, M3G and M6G were 0.50, 0.22 and 0.55 ng/mL, respectively, and the method was linear from LLOQ to 200 ng/mL. For plasma, a volume of 100 microL was precipitated with acetonitrile containing internal standards (deuterated morphine and metabolites). The supernatant was evaporated and reconstituted in 0.05% TFA before the desalting process. The LLOQs for sheep plasma were 2.0 and 3.1 ng/mL and the ranges were 2.0-2000 and 3.1-3100 ng/mL for morphine and M3G, respectively. For human plasma, the LLOQs were 0.78, 1.49 and 0.53 ng/mL and the ranges were 0.78-500, 1.49-1000 and 0.53-500 ng/mL for morphine, M3G and M6G, respectively.

Central Nervous System Stimulants↗

PubMed2003

Multifunctional gratings for surface-emitting lasers: design and implementation.

We experimentally demonstrate the use of two different multifunctional grating couplers in surface-emitting lasers for improved beam quality and advanced beam profiles. The lasers used for the demonstration are grating-based unstable resonator lasers, each with a grating coupler for surface emission and beam shaping. The new design method, described in detail, allows for simultaneous optimization of arbitrary feedback and outcoupling characteristics of the grating coupler. The first coupler is designed to reduce feedback to the resonator that would otherwise disturb the operation of the laser and lower the beam quality and to produce an output beam focused to four spots. The second coupler is designed to provide the feedback needed to support the unstable resonator, eliminating one feedback grating, and simultaneously focus the output beam to a single spot. As far as we know, this is the first time such multifunctional couplers are used in grating-coupled surface-emitting lasers. The couplers provide near-diffraction-limited spots that are a considerable improvement compared with previous lasers with no feedback control in the couplers.

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PubMed2002

Input waveguide grating couplers designed for a desired wavelength and polarization response.

Input grating couplers are used to couple light from free space into a waveguide and can provide additional functions such as focusing and beam splitting of the light into arbitrary desired positions in the waveguide. We show that it is possible to design the couplers so that they perform different desired functions depending on the polarization or wavelength of the incident light. We demonstrate experimentally a number of couplers that may be of interest, e.g., in optical fiber communications. Examples are polarization-independent couplers, designed to have the same response for two orthogonal polarizations of the incident light, and couplers for demultiplexing in wavelength division multiplexing applications, designed to separate and focus different input wavelengths to different positions in the waveguide.

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PubMed2002

Fan-out diffractive optical elements designed for increased fabrication tolerances to linear relief depth errors.

The intensity uniformity of the spots generated by fan-out diffractive optical elements (DOEs) (or kinoforms) is often highly sensitive to any fabrication error that leads to a deviation of the surface-relief depth of the DOE from its design value. Many of the fabrication errors, such as those that are due to insufficient control of development or etch rates, increase almost linearly with the desired relief depth in every position of the DOE. We present an algorithm for designing fan-out DOEs with a significantly reduced sensitivity of the intensity uniformity to such errors. The reduced sensitivity can be obtained without reducing the efficiency of the DOE. Experimental results for fabricated DOEs show that reduced sensitivity is also obtained in practice.

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