Biomedical subjects

J-D Kim

Publications and source records attributed to J-D Kim.

4 recordsLinked to original sources

PubMed2006

Metastatic tumours to the jaws and oral soft tissues: a retrospective analysis of 41 Korean patients.

This article describes a pooled analysis of 41 Korean patients with metastatic oral tumours. The data reviewed are from Korean dental and medical case reports published between 1983 and 2004. The mean age was 55.2 years, and the male-to-female ratio was 1.9:1. There were more metastases in the jawbone than in oral soft tissues. The lung was the most common primary site for jawbone metastases, whereas the liver was for those of oral soft tissues. In contrast to reports in Western literature of the breast being the most common primary site, the liver was the most common primary site, followed by the lung and thyroid. These differences may be caused by a relatively high incidence rate of hepatocellular carcinoma in Korea.

Adult↗

PubMed2005

Isolation and characterization of a bio-agent antagonistic to diatom, Stephanodiscus hantzschii.

AIMS: Identification of bacterium HYK0203-SK02 and its lysis of Stephanodiscus hantzschii. METHODS AND RESULTS: In an effort to identify a bio-agent capable of controlling S. hantzschii blooms, we used the algal lawn method to identify 76 bacteria in relevant water samples. Of these, the seven isolate showed algicidal activity against S. hantzschii; isolate HYK0203-SK02 exhibited the strongest algicidal activity, and was used for further analysis. 16S rDNA sequencing of this isolate allowed us to identify HYK0203-SK02 as a strain of Pseudomonas putida (99.2%). Growth of S. hantzschii was strongly suppressed by bacteria in all growth phases, with the strongest algicidal activity noted against diatoms in the exponential stage (5-18 days). Host range assays revealed that isolate HYK0203-SK02 also strongly inhibited the growth of Microcystis aeruginosa, but stimulated growth of the diatom Cyclotella sp., which has a similar structure to that of S. hantzschii. Biochemical assays revealed that the algicidal substance seemed to be localized in the cytoplasmic membrane of this newly identified algicidal bacterium. CONCLUSION: The algicidal bacteria P. putida HYK0203-SK02 caused cell lysis and death of not only diatom S. hantzschii but also cyanobacteria M. aeruginosa, dramatically. Algicidal substance might be located at the compartment of cytoplasmic membrane. SIGNIFICANCE AND IMPACT OF THE STUDY: Taken together, our results indicate that P. putida HYK0203-SK02 may be a potential bio-agent for future use in controlling freshwater diatomic blooms.

Bacteriolysis↗

PubMed2003

GENIA corpus--semantically annotated corpus for bio-textmining.

MOTIVATION: Natural language processing (NLP) methods are regarded as being useful to raise the potential of text mining from biological literature. The lack of an extensively annotated corpus of this literature, however, causes a major bottleneck for applying NLP techniques. GENIA corpus is being developed to provide reference materials to let NLP techniques work for bio-textmining. RESULTS: GENIA corpus version 3.0 consisting of 2000 MEDLINE abstracts has been released with more than 400,000 words and almost 100,000 annotations for biological terms.

Abstracting and Indexing↗

PubMedDate not supplied

Thermo-sensitive microparticles of PNIPAM-grafted ethylcellulose by spray-drying method.

The thermo-sensitive polymer, PNIPAM-grafted ethylcellulose, was synthesized and it was confirmed by FTIR spectroscopy that PNIPAM was successfully grafted onto ethylcellulose. Microparticles were prepared by the spray-drying method using a B-191 Mini Spray Dryer. Their morphology, observed by scanning electron microscopy (SEM), showed irregular spheres with rugged surfaces, and narrow size distribution. In a model delivery system, ethylcelullose-g-PNIPAM was used as the polymer wall material and allopurinol was used as the model drug. The release rate of allopurinol from ECGPN8 microparticles was slower at 40 degrees C (above the LCST) than that of 25 degrees C (below the LCST), probably due to the collapse of PNIPAM chains by temperature. Although PNIPAM was the large part of wall material, the thermo-sensitive release behavior was not so obvious. It is believed that the release of allopurinol from the microparticles is more dependent on the porous structure of microparticles than the conformational change of PNIPAM, created by the rapid evaporation of solvent during the spray-drying process.

Acrylic Resins↗