PubMed Health⌕ Search

Biomedical subjects

J-F Henry

Publications and source records attributed to J-F Henry.

6 recordsLinked to original sources
PubMed2006

Degradation in insulin sensitivity with increasing severity of the metabolic syndrome in obese postmenopausal women.

AIM: We investigated the relationship between insulin sensitivity and the graded increase in the number of features of the metabolic syndrome in a cross-sectional sample of obese postmenopausal women. We hypothesized that insulin sensitivity would deteriorate with an increased number of metabolic syndrome phenotypes. METHODS: Insulin sensitivity was measured in 75 obese postmenopausal women (age: 57.3 +/- 5.3 years; BMI: 32.8 +/- 4.5 kg/m2) by using both the hyperinsulinaemic-euglycaemic clamp and the homeostasis model assessment (HOMA-IR). Features of the metabolic syndrome included visceral fat (>130 cm2), HDL-cholesterol (<1.29 mmol/l), fasting triglycerides (> or =1.7 mmol/l), blood pressure (> or =130/> or =85 mmHg) and fasting glucose (> or =6.1 mmol/l). Participants were classified into three categories based on the presence of metabolic syndrome phenotypes: 0-1 vs. 2 vs. > or =3 features of the metabolic syndrome. RESULTS: We found that insulin sensitivity decreased in a graded fashion (12.19 +/- 3.2 vs. 11.80 +/- 2.3 vs. 9.29 +/- 2.6 mg/min/FFM) and HOMA-IR increased in a similar manner (2.95 +/- 1.1 vs. 3.28 +/- 1.3 vs. 4.65 +/- 2.2), as the number of features of the metabolic syndrome increased from 0-1 to > or =3. When insulin sensitivity was statistically adjusted for visceral fat (as measured by computed tomography) and plasma triglycerides, the differences among groups were abolished. CONCLUSIONS: These findings suggest that a decreased insulin sensitivity is associated with increased features of the metabolic syndrome in obese postmenopausal women and that visceral fat as well as plasma triglyceride accumulation might be potential mediators of this relationship.

Adipose Tissue↗
PubMed2005

[Lateral endoscopic approach for thyroid and parathyroid surgery].

The endoscopic lateral approach in thyroid and parathyroid surgery is achieved by developing the plane between the carotid sheath laterally and the strap muscles medially. This approach allows direct access to the posterior aspect of the thyroid lobe, without the need for the dissection of the strap muscles and without the need for medial retraction of the thyroid during the procedure. The lateral approach aided by endoscopic magnification provides the surgeon with the ideal view with which to safely dissect the vital structures found in the retro-thyroid space such as the inferior thyroid artery, the recurrent laryngeal nerve and the parathyroid glands. This approach was initially adopted in primary hyperparathyroidism caused by a single adenoma that had been localized preoperatively. It is now also offered to patients with an isolated thyroid nodule smaller than 25 mm in diameter requiring surgical excision. Experience with 408 parathyroidectomies and the preliminary results of 38 thyroid lobectomies allows the authors to recommend this technique to appropriately selected patients.

Endoscopy↗
PubMed2003

Identification of patients with a non-recurrent inferior laryngeal nerve by duplex ultrasound of the brachiocephalic artery.

A non-recurrent inferior laryngeal nerve (NRILN) is a rare anomaly that may increase the risk of injury during thyroid surgery. A NRILN results from an embryologic developmental abnormality of the aortic arches, demonstrated by the absence of the brachiocephalic artery and the presence of an aberrant subclavian artery (arteria lusoria). In our experience 100% of 104 patients with a NRILN were shown to have these abnormalities. We postulated that duplex scanning of the brachiocephalic artery could identify patients at risk of a NRILN. Twelve patients with an operative diagnosis of a right NRILN and associated vascular abnormalities underwent postoperative duplex scanning of the brachiocephalic artery. The examination was performed using a 7.5 or 3.5 MHz transducer. The average duration of assessment was 5 min. The absence of the brachiocephalic artery and the direct origin of the right common carotid artery from the arch of the aorta were demonstrated in each patient. Duplex scanning is a simple noninvasive method of identifying patients with the arterial abnormalities responsible for a NRILN. This may be used in the preoperative assessment of selected patients.

Brachiocephalic Trunk↗