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JM Anderson

Publications and source records attributed to JM Anderson.

3 recordsLinked to original sources

Near-body flow dynamics in swimming fish

We consider the motions and associated flow patterns of a swimming giant danio (Danio malabaricus). Experimental flow-visualization techniques have been employed to obtain the unsteady two-dimensional velocity fields around the straight-line swimming motions and a 60 degrees turn of the fish in the centerline plane of the fish depth. A three-dimensional numerical method is also employed to predict the total velocity field through simulation. Comparison of the experimental and numerical velocity and vorticity fields shows good agreement. The fish morphology, with its narrow peduncle region, allows for smooth flow into the articulated tail, which is able to sustain a large load for thrust generation. Streamlines of the flow detail complex processes that enhance the efficiency of flow actuation by the tail. The fish benefits from smooth near-body flow patterns and the generation of controlled body-bound vorticity, which is propagated towards the tail, shed prior to the peduncle region and then manipulated by the caudal fin to form large-scale vortical structures with minimum wasted energy. This manipulation of body-generated vorticity and its interaction with the vorticity generated by the oscillating caudal fin are fundamental to the propulsion and maneuvering capabilities of fish.

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Host response to tissue engineered devices.

The two main components of a tissue engineered device are the transplanted cells and the biomaterial, creating a device for the restoration or modification of tissue or organ function. The implantation of polymer/cell constructs combines concepts of biomaterials and cell transplantation. The interconnections between the host responses to the biomaterial and transplanted cells determines the biocompatibility of the device. This review describes the inflammatory response to the biomaterial component and immune response towards transplanted cells. Emphasis is on how the presence of the transplanted cell construct affects the host response. The inflammatory response towards a biomaterial can impact the immune response towards transplanted cells and vice versa. Immune rejection is the most important host response towards the cellular component of tissue engineered devices containing allogeneic, xenogeneic or immunogenic ex vivo manipulated autologous cells. The immune mechanisms towards allografts and xenografts are outlined to provide a basis for the mechanistic hypotheses of the immune response towards encapsulated cells, with antigen shedding and the indirect pathway of antigen presentation predominating. A review of experimental evidence illustrates examples of the inflammatory response towards biodegradable polymer scaffold materials, examples of devices appropriately integrated as assessed morphologically with the host for various applications including bone, nerve, and skin regeneration, and of the immune response towards encapsulated allogeneic and xenogeneic cells.

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Biodegradation and biocompatibility of PLA and PLGA microspheres.

A fundamental understanding of the in vivo biodegradation phenomenon as well as an appreciation of cellular and tissue responses which determine the biocompatibility of biodegradable PLA and PLGA microspheres are important components in the design and development of biodegradable microspheres containing bioactive agents for therapeutic application. This chapter is a critical review of biodegradation, biocompatibility and tissue/material interactions, and selected examples of PLA and PLGA microsphere controlled release systems. Emphasis is placed on polymer and microsphere characteristics which modulate the degradation behaviour and the foreign body reaction to the microspheres. Selected examples presented in the chapter include microspheres incorporating bone morphogenetic protein (BMP) and leuprorelin acetate as well as applications or interactions with the eye, central nervous system, and lymphoid tissue and their relevance to vaccine development. A subsection on nanoparticles and nanospheres is also included. The chapter emphasizes biodegradation and biocompatibility; bioactive agent release characteristics of various systems have not been included except where significant biodegradation and biocompatibility information have been provided.

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