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Biomedical subjects

JN Greene

Publications and source records attributed to JN Greene.

At least 19 recordsLinked to original sources
PubMed1995

Hematological Effects of Human Immunodeficiency Virus Infection.

Anemia, thrombocytopenia, and neutropenia are common manifestations in patients with human immunodeficiency virus infection that become more frequent and severe with progression from the asymptomatic state to acquired immunodeficiency syndrome (AIDS). Causes of anemia in AIDS include nutritional deficiencies, infection, and marrow suppression by antiretroviral drugs and by the disease itself. Autoimmune hemolysis and blood loss from gastrointestinal lymphoma or Kaposi sarcoma may also contribute. Granulocytopenia may be due to infection, autoimmunity, or bone marrow suppression by drugs or the immunodeficiency virus. Lymphopenia, the classic hallmark of the disease, typically affects T-helper cells first and worsens as the disease advances. Lymphopenia is a result of the direct cytopathic effects of the virus. Thrombocytopenia can occur from antibodies causing an idiopathic thrombocytopenic purpura-like state from bone marrow suppression or from thrombotic thrombocytopenic purpura. A prolonged partial thromboplastin time due to a coagulopathy caused by lupus anticoagulant causing has been described. A variety of malignancies occurs.

Journal Article↗
PubMed1994

Infectious and Inflammatory Diseases Masquerading as Head and Neck Malignancy.

Lesions of the head and neck and upper respiratory tract can be quite difficult to diagnose at times when presenting symptoms and signs appear out of character or biopsy of affected tissue reveals nonspecific results. A heightened awareness of important historical facts such as place of birth and residence, travel and occupation may provide important clues to narrow the differential diagnosis. Not all destructive ulcers and tumors of the head and neck are malignant. Inflammatory and infectious diseases that mimic cancer are presented.

Journal Article↗