PubMed Health⌕ Search

Biomedical subjects

Jack E Riggs

Publications and source records attributed to Jack E Riggs.

15 recordsLinked to original sources
PubMed2005

Impact of institution of a stroke program upon referral bias at a rural academic medical center.

CONTEXT: Referral bias reflecting the preferential hospital transfer of patients with intracerebral hemorrhage (ICH) has been demonstrated as the major contributing factor for an observed high nonrisk-adjusted in-hospital crude acute stroke mortality rate at a rural academic medical center. PURPOSE: This study was done to assess the impact of a clinical acute stroke program upon referral bias in August 2000. METHODS: A chart review of acute stroke (DRG 14) discharges during 2001 from a rural academic medical center was compared with the same data from 1999. RESULTS: The odds ratio of ICH in hospital-transfer patients compared with nonhospital-transfer patients decreased from 11.7 in 1999 to 3.2 in 2001 (P < .035). CONCLUSIONS: This study demonstrated the rapid magnitude and significance that clinical programs can have upon referral bias. Changes in referral bias may be more rapid at rural academic medical centers because of the relative lack of health care delivery competition.

Academic Medical Centers↗
PubMed2004

Critical illness myopathy associated with hyperthyroidism.

A 51-year-old woman was admitted to the intensive care unit for exacerbation of chronic obstructive pulmonary disease. She received antibiotics, neuromuscular blocking agents, and steroids. After 8 days in the intensive care unit, she was noted to be severely weak, her serum creatine kinase had risen to 1,692 U/L (normal, 20-220 U/L), and a muscle biopsy was consistent with critical illness myopathy. As a result of evaluating for resting tachycardia, the patient was found to be hyperthyroid. Her weakness rapidly improved within 1 month after treatment of her hyperthyroidism with iodine-131 and methimazole. The metabolic alterations associated with hyperthyroidism may enhance the risk of developing critical illness myopathy after the administration of antibiotics, neuromuscular blocking agents, and steroids in the intensive care unit.

Critical Illness↗
PubMed2004

The contributions of Lavoisier, Carnot, and Mayer to understanding heat illness.

Although heat illness has been described throughout recorded history, an understanding of its pathophysiology was only achieved in the 20th century. Lavoisier, Carnot, and Mayer described fundamental concepts about thermodynamics in the late 18th and early 19th centuries that were crucial to the eventual understanding of heat illness. Lavoisier recognized that the human body was a heat engine. Carnot recognized that useful heat engines must dissipate heat. Mayer recognized that humans possess the capacity to regulate body heat. The fundamental contributions of Lavoisier, Carnot, and Mayer to the understanding of heat illness have gone largely unacknowledged.

Body Temperature↗
PubMed2003

Channelopathies in pediatric neurology.

Although the genetic neurologic channelopathies are uncommon, they serve as models that further understanding of disease mechanisms in paroxysmal disorders. Many other neurologic channelopathies likely will be identified in the future.

Child↗
PubMed2003

Congenital myopathies/dystrophies.

The congenital myopathies and congenital muscular dystrophies are a group of relatively infrequent neuromuscular disorders. Ultimate understanding of these disorders, however, will undoubtedly shed considerable light on skeletal muscle development and function. Three classical congenital myopathies are central core disease, nemaline myopathy, and centronuclear myopathy. The congenital muscular dystrophies are often distinguished by whether or not they are associated with clinically evident cerebral involvement.

Child↗
PubMed2003

Association between early returns and frequent ED visits at a rural academic medical center.

The objective of this study was to examine the influence of frequent emergency department (ED) use on early returns to the ED at a large rural academic medical center. An analysis was done of all 35,440 visits by 22,442 individuals to a large rural academic medical center ED during calendar year 2000. Of 35,440 ED visits, there were 1,992 (5.62%) return visits within 72 hours (early return). Frequent ED visits (visits made by individuals making 4 or more visits per year) was a predictor of early return visits (odds ratio [OR] 3.21, 95% confidence interval [CI] 2.93-3.52; Wald chi(2), P <.0001). Of 22,442 individuals who came to the ED during the study period, 1,601 (7.13%) returned within 72 hours. Frequency of ED use by a particular individual (4 or more visits per year) was also a predictor of early return for that individual (OR 14.55, 95% CI 12.84-16.48; Wald chi(2), P <.000001). The high rate of early returns to this rural academic ED was significantly associated with frequent visits (4 or more times per year) to the ED by particular individual.

Academic Medical Centers↗
PubMed2003

Motor axonal injury and amyotrophic lateral sclerosis: risk assessment using a reverse probability analysis technique.

A relationship between antecedent trauma and amyotrophic lateral sclerosis (ALS) has been clinically suspected for over a century. Nine cases of ALS that occurred over a 14-year period in young U.S. men (age range, 28-43 years) following trauma that produced motor axonal injury that antedated (range, 5-42 months) the onset of ALS have been reported by a single neurologist. After estimating the number of cases of ALS in 28- to 43-year-old American men that would be expected to occur over a 14-year period, a reverse probability analysis technique was used to determine the expected incidence rates of motor axonal injury in a ideally matched control population that would give probabilities of 0.05, 0.01, and 0.001 of observing nine or more instances of motor axonal injury occurring during the previous 5 to 42 months. This analysis was repeated assuming that this one neurologist had only reported 50 and 10% of all instances of ALS that occurred during this 14-year period in American men ages 28 to 43 years who had experienced trauma that produced motor axonal injury that occurred 5 to 42 months before the onset of ALS. Reverse probability analysis is a technique that can be used in performing risk assessments.

Adult↗
PubMed2002

Neurologic manifestations of electrolyte disturbances.

Electrolyte disturbances occur commonly and are associated with a variety of characteristic neurologic manifestations involving both the central and peripheral nervous systems. Electrolyte disturbances are essentially always secondary processes. Effective management requires identification and treatment of the underlying primary disorder. Since neurological symptoms of electrolyte disorders are generally functional rather than structural, the neurologic manifestations of electrolyte disturbances are typically reversible. The neurologic manifestations of serum sodium, potassium, calcium, and magnesium disturbances are reviewed.

Brain↗
PubMed2002

In-hospital stroke mortality, hospital transfers, and referral bias at a rural academic medical center.

A chart review of acute stroke (DRG 14) discharges from a rural academic medical center in 1999 was performed because of an observed high in-hospital crude acute stroke mortality rate. An analysis of the results of this chart review demonstrated that the odds ratio of intracerebral hemorrhage in patients who had been transferred from other hospitals was 11.7 compared to intracerebral hemorrhage in nonhospital transfer patients (p < 0.00001). This finding illustrates the potential magnitude and significance of referral bias at a rural academic medical center.

Academic Medical Centers↗
PubMed2002

Nitrosative stress, uric Acid, and peripheral nerve function in early type 1 diabetes.

The present study was performed to determine whether nitric oxide overproduction is associated with deterioration in peripheral nerve function in type 1 diabetes. We measured peripheral nerve function and biochemical indicators of nitrosative stress annually for 3 years in 37 patients with type 1 diabetes. Plasma nitrite and nitrate (collectively NO(x)) were 34.0 +/- 4.9 micro mol/l in the control subjects and 52.4 +/- 5.1, 50.0 +/- 5.1, and 49.0 +/- 5.2 in the diabetic patients at the first, second, and third evaluations, respectively (P < 0.01). Nitrotyrosine (NTY) was 13.3 +/- 2.0 micro mol/l in the control subjects and 26.8 +/- 4.4, 26.1 +/- 4.3, and 32.7 +/- 4.3 in the diabetic patients (P < 0.01). Uric acid was suppressed by 20% in the diabetic patients (P < 0.001). Composite motor nerve conduction velocity for the median, ulnar, and peroneal nerves was decreased in patients with high versus low NTY (mean Z score -0.522 +/- 0.25 versus 0.273 +/- 0.22; P < 0.025). Patients with high NO(x) had decreased sweating, and those with suppressed uric acid had decreased autonomic function. In conclusion, nitrosative stress in early diabetes is associated with suppressed uric acid and deterioration in peripheral nerve function.

Adolescent↗
PubMed2002

Heart block associated with spinocerebellar ataxia type 2.

A 20-year-old man was discharged from the U.S. Army because of increasing gait abnormalities. One year later, he developed episodes of syncope secondary to high-degree atrial/ventricular block with periods of complete heart block and ventricular asystole. A permanent dual-chamber, rate-responsive cardiac pacemaker was implanted. At age 29 years, an abnormal expansion of the CAG trinucleotide repeat in the ataxin-2 gene on chromosome 12 was identified. This case suggests that cardiac conduction abnormalities should be included as part of the recognized clinical heterogeneity of spinocerebellar ataxia type 2.

Adult↗