Biomedical subjects

Jacques Corcos

Publications and source records attributed to Jacques Corcos.

At least 37 records · Page 2Linked to original sources

PubMed2005

An investigation of dose titration with darifenacin, an M3-selective receptor antagonist.

OBJECTIVES: To evaluate the efficacy, tolerability and safety of a flexible-dosing strategy with darifenacin, an M(3)-selective receptor antagonist, in patients with symptoms of overactive bladder (OAB). PATIENTS AND METHODS: In this multicentre double-blind 12-week study, 395 patients (aged 22-89 years; 84% female) with OAB symptoms for >6 months were randomized (2 : 1) and received once-daily treatment with darifenacin controlled-release tablets 7.5 mg (268 patients) or matching placebo (127). After 2 weeks of treatment, the efficacy, safety and tolerability were assessed and the dose increased to 15 mg once daily (pseudo-increase for placebo recipients) if additional efficacy was required by both the patient and physician. In the week before clinic visits (at 2 and 12 weeks), patients recorded incontinence episodes (primary efficacy endpoint) and several secondary efficacy variables in an electronic daily diary. Safety and tolerability were evaluated from withdrawal rates and adverse-event reports. RESULTS: The treatment groups had comparable baseline characteristics. Similar proportions of darifenacin (59%) and placebo (68%) recipients increased the dose at 2 weeks; at 12 weeks patients on darifenacin (overall group) had a significantly greater reduction in the median number of incontinence episodes per week than had those on placebo, at - 8.2 (-62.9%) and - 6.0 (-48.1%), respectively (P = 0.035). There were also significant improvements in voiding frequency (P = 0.001), bladder capacity (volume voided; P = 0.036), frequency of urgency (P < 0.001), severity of urgency (P = 0.013) and number of significant leaks/week (i.e. incontinence episodes needing a change of clothing or pads, per week; P = 0.010) for darifenacin over placebo. Subset analysis suggested that some patients (those remaining on darifenacin 7.5 mg) were more sensitive to darifenacin than those who increased the dose, based on both efficacy and adverse events. Continued treatment with 7.5 mg for 'sensitive' patients, and an increased dose (to 15 mg) for remaining patients, resulted in comparable outcomes by 12 weeks. The most common treatment-related adverse events were mild-to-moderate dry mouth and constipation, which led to discontinuation in < 3.0% of darifenacin-treated patients and < 1.0% of the placebo group. Central nervous system and cardiovascular adverse events were comparable to those with placebo. CONCLUSIONS: Darifenacin appears to be an effective, well-tolerated and flexible treatment for patients with OAB, allowing individualized dosing according to patient needs.

Adult↗

PubMed2005

Canadian guidelines for the management of benign prostatic hyperplasia.

OBJECTIVE: To develop the first Canadian guidelines for the management of lower urinary tract symptoms in men with benign prostatic hyperplasia (BPH). METHODS: These guidelines, developed under a mandate provided by the Canadian Urological Association (CUA), were a collaborative effort between the CUA guidelines committee and the Canadian Prostate Health Council. BPH guidelines developed by the American Urological Association, the European Association of Urology, the World Health Organization International Consultation on BPH, and similar committees from Germany, Sweden and Australia were reviewed. The committee further reviewed a systematic literature search, updated to May 2004, and systematically derived Canadian urological opinion data. RESULTS: The subsequent Canadian BPH guidelines were developed as an evidence based consensus among the committee members. Mandatory evaluation includes history, physical examination and urinalysis, while a symptom inventory and PSA in selected patients are recommended. Serum creatinine, uroflow, voiding diary, post void residual and sexual function questionnaire are optional. Unless there is an indication, other related tests are not recommended. Treatment choices should be governed by the severity of the symptoms, bother and patient preference. Guidelines for medical, surgical and minimally invasive treatment as well as special considerations are described in terms of guideline, option and recommendation. CONCLUSIONS: Diagnostic and treatment guidelines for BPH reflect the Canadian social priorities, economics, socialized medical practice, manpower issues, and medicolegal considerations.

Canada↗

PubMed2004

A randomized, double-blind, parallel-group comparison of controlled- and immediate-release oxybutynin chloride in urge urinary incontinence.

OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of a new PO controlled-release (CR) QD oxybutynin tablet relative to PO immediate-release (IR) TID oxybutynin in patients with urge urinary incontinence (UI). METHODS: In this multicenter, double-blind trial, patients with UI (> or = 7 episode/wk) and frequency (> or = 8 micturitions/d) were randomized to CR or IR oxybutynin for 6 weeks. Patients initiated treatment at 15 mg/d and the dose was adjusted (in 5-mg/d increments) over 2 weeks according to tolerability. Efficacy (UI episodes, voids, absorbent pads used, urgency, and volume voided per micturition) was assessed during the final 2 weeks of treatment. Tolerability was assessed by evaluating adverse events and treatment withdrawals. RESULTS: Of the 125 patients randomized, 94 (75%) were evaluable for efficacy; tolerability was assessed in all patients. In the CR group, 48 patients (91%) were women and 5 (9%) were men; the mean (SD) age was 58.0 (12.4) years (range, 26-78 years). In the IR group, 37 patients (90%) were women and 4 (10%) were men; the mean (SD) age was 60.6 (14.8) years (range, 26-83 years). Both CR and IR oxybutynin significantly reduced the mean number of total UI episodes per week (both P < 0.001 vs baseline). Both treatments produced equivalent reductions in mean voiding frequency and urinary urgency (all P < 0.001 vs. baseline). Significantly more patients rated CR oxybutynin tolerable on the initial dose of 15 mg/d (P = 0.020) and completed the study at a dose of > or = 15 mg/d (P = 0.018). Dry mouth was the most common adverse event, reported by 68% and 72% of patients in the CR and IR oxybutynin groups, respectively. CONCLUSIONS: Among the patients with urge UI included in this study, CR oxybutynin was as effective as IR oxybutynin for improving primary symptoms, with the additional benefit of QD administration.

Adult↗

PubMed2004

Symptom severity and QOL scales for urinary incontinence.

Symptoms of incontinence are common, particularly among older people, and incontinence can have a severe effect on the quality of life of some individuals at any age. A number of treatments are available, most of which aim to reduce the occurrence of incontinent episodes or to limit the effects of the disorder on everyday life. In research and clinical practice, it is essential that the symptoms and effects of incontinence be properly assessed and recorded. The only valid means of measuring patients' perspectives is through the use of psychometrically robust self-report questionnaires. Incontinence may be experienced as part of the symptom complex of a range of conditions (e.g., benign prostatic diseases or fistulas), and the effect of incontinence on quality of life varies depending on the severity of the condition and other psychosocial and medical factors. Questionnaires with acceptable levels of psychometric testing are identified and recommended for use in clinical practice and research investigations according to the following categories: (1) questionnaires to assess symptoms of incontinence, (2) generic health-related quality-of-life questionnaires to assess the effect of incontinence on quality of life, and (3) incontinence-specific measures to assess the effect and bothersomeness of incontinence on quality of life.

Humans↗

PubMed2004

Complications of tension-free vaginal tape surgery: a multi-institutional review.

OBJECTIVE: To analyse the complications of tension-free vaginal tape (TVT) surgery, a minimally invasive alternative for treating patients with stress urinary incontinence (SUI), at six institutions, and to review the management of these complications and their effect on patient outcome. PATIENTS AND METHODS: In all, 241 patients who had a TVT procedure by six urologists at six hospitals (two university and four community) were reviewed retrospectively by the same urologist. Complications during and after surgery, and their management, were analysed. RESULTS: Complications during surgery included bladder perforation in 48 patients (5.8%) and blood loss > 500 mL in 16 (2.5%). Immediate complications after surgery were urinary retention (>24 h after) in 47 patients (19.7%), pelvic haematoma in four (1.9%) and suprapubic wound infection in one (0.4%). Of the 47 patients in retention, 32 were in retention for <48 h and treated with an indwelling catheter. The 15 remaining patients were treated with an indwelling catheter (one) or clean intermittent catheterization for a mean of 22 days. To correct the retention the TVT was released in seven patients and the tape sectioned in three. Late complications were de novo urgency, persistent suprapubic discomfort and intravaginal tape erosion in 36 (15%), 18 (7.5%) and one (0.4%) patient, respectively. Most of these complications resolved with observation and medical management, but intravaginal tape erosion required partial resection of the tape with closure and repair of the vaginal mucosa. CONCLUSIONS: The present TVT complication rates were slightly higher than reported previously. This multi-institutional review in both academic and community hospitals may better reflect the morbidity of TVT insertion in clinical practice. TVT is a highly effective, minimally invasive method for treating SUI. A stricter definition of each complication and a better understanding of the mechanism of these complications may further improve the surgical outcome and decrease patient morbidity.

Adult↗

PubMed2004

Prevalence of overactive bladder and incontinence in Canada.

AIMS OF STUDY: The main objectives of the study were to measure the prevalence of overactive bladder (OAB) with its sub-types (wet OAB, dry OAB, mixed OAB) in the Canadian population and to assess prevalence variations in according to gender and age. METHODS: The prevalence of OAB in Canada was investigated via a validated, computer-assisted telephone interview (CATI) system. The interviews were conducted in two steps: an initial questionnaire evaluating if respondents suffered from OAB, followed by a detailed questionnaire completing the assessment. The final data were weighted according to the census of metropolitan areas and by gender, on the basis of Canadian population statistics. RESULTS: A sample of 3249 adults, aged 35 years and older, was interviewed with the CATI system. Six hundred and three respondents were found to suffer from wet OAB, dry OAB or mixed OAB. The overall prevalence of OAB in this Canadian population was evaluated to be 18.1%. It was lower in men (14.8%) than in women (21.2%). Dry OAB was assessed to be the highest sub-type, with a rate of 13.6%, 11.7% in men and 15.6% in women. The prevalence of wet OAB was estimated to be 2.3%, 2% in men and 2.6% in women. Finally, the prevalence of mixed OAB was found to be 1.2% in this population, with a much lower prevalence in men (0.3%) than in women (2.1%). Dry OAB increased with age in both men and women; wet OAB was markedly higher in both men and women over the age of 75 years. No correlation was observed between age and prevalence of mixed OAB in women, whereas a linear relationship was noted between the two variables in men. CONCLUSIONS: This is the first large study of OAB symptoms prevalence in the Canadian population aged 35 years and older. We established that OAB prevalence was higher in women than in men, with women experiencing more dry OAB and mixed OAB than men.

Adult↗

PubMed2004

A survey of urological manpower, technology, and resources in Canada.

INTRODUCTION: Knowledge of the current status of manpower and resources is important in understanding the state of any medical specialty, and critical in planning for future recruitment, funding and infrastructure development. METHODS: In 2003, the Canadian Urological Association (CUA) conducted two nationwide surveys examining manpower, resources, and the technology available. One survey went only to academic and hospital leaders across the country (the resources survey), while the other was sent to the entire general membership of the CUA. RESULTS: The response rate for the resources survey was 67%, while that for the membership survey was 50.4%. The respondents' ages were evenly distributed, with the modal 5-year range being 51 to 55 years of age. Eighty-eight percent of respondents were Canadian-trained. Two-thirds of respondents spent over 80% of their practice time in direct patient care, and most practiced general urology. The majority of respondents practiced in smaller hospitals: 57.6% in centres with 300 or fewer inpatient beds, and 47.2% of centres reported < 500 procedures/year. Community hospitals (62% of responses to the resources survey) generally had fewer advanced technologies than academic centres. A quarter of the cystoscopy equipment used by respondents was over 15 years old. CONCLUSIONS: The results of these surveys present a snapshot of the current state of urology resources and manpower across Canada, potentially allowing better planning and negotiations with hospitals and governments.

Biomedical Technology↗

PubMed2004

Tissue reactions of the rabbit urinary bladder to cadaveric human fascia lata and polypropylene surgical mesh.

OBJECTIVE: To evaluate and compare histological tissue reactions of the urinary bladder to human cadaveric fascia lata (CFX) slings and synthetic mesh. METHODS: Thirty rabbits were randomized to three groups: group A (multifilament - Surgipro Mesh) 12 animals, group B (CFX) 12 animals, and group C (surgical controls) 6 animals. A piece of Mesh or CFX was fixed in direct contact with the anterior bladder neck wall. The control group simply underwent sham bladder manipulation. The animals were sacrificed at 6- and 12-week intervals, and their bladders were collected for histological analysis. RESULTS: Group A showed fibrosis within the detrusor of the bladder wall in half of specimens, including marked trans-mural inflammation in one case. The graft was incorporated within a plate of fibrous tissue with a foreign body-type granulomatous reaction to the synthetic material. In group B, no fibrosis or inflammation was seen within the bladder wall. The graft showed marked inflammation (mixed cell infiltrate) in all specimens, whereas foci of devitalized collagen with associated foreign body-type granulomatous changes and dystrophic calcification were present in more than half of specimens. No histopathological alteration was found in the control group. CONCLUSION: Significant histopathological changes within the bladder wall occur in response to synthetic mesh as compared to CFX over two tested time intervals. We believe these differences are related to the lack of reported adverse outcome with the use of cadaveric fascia lata slings in regard to graft erosion or infection when compared to complications occurring with the use of artificial materials.

Animals↗

PubMed2003

Surgery versus collagen for female stress urinary incontinence: economic assessment in Ontario and Quebec.

INTRODUCTION AND OBJECTIVE: The purpose of this study was to evaluate the cost-effectiveness of surgery versus collagen injection to treat female stress urinary incontinence after the failure of initial surgical treatment. The analysis was conducted from the health care system perspectives of Ontario and Quebec. MATERIALS AND METHODS: A decision-tree was constructed to compare each of three surgeries (i.e., retropubic suspension, transvaginal suspension, sling procedures) with collagen. An average cost estimate was generated for each intervention, as was an incremental cost-effectiveness ratio for each surgery-collagen comparison. RESULTS: In both Ontario and Quebec, the treatment with the lowest average cost was collagen (Ontario: collagen = 2695 dollars; Quebec: collagen = 2718 dollars). However, the surgeries had higher probabilities of success (defined as 'cure' - no urine leakage during follow-up examinations), with point estimates of at least.79 (.53 for collagen). Incremental cost-effectiveness ratios for the base case analyses of all treatment comparisons indicated that the cost to cure an additional patient with surgery could range from 1824 dollars to 6814 dollars in Ontario and 1388 dollars to 3008 dollars in Quebec. These ratios were sensitive to changes in the mean number of injections for collagen patients and to a reduction in the length of hospital stay for surgery to 1 day. CONCLUSIONS: Collagen injection may be cost-effective as a follow-up treatment to initial surgical failure in both Ontario and Quebec when the number of injections is kept to a minimum and hospital stays after surgery are relatively lengthy. Otherwise, surgery may be cost-effective.

Collagen↗

PubMed2002

Identifying cut-off scores with neural networks for interpretation of the incontinence impact questionnaire.

We propose to determine cut-off scores for the Incontinence Impact Questionnaire (IIQ) based on the neural network (NN) approach. These cut-off scores should discriminate between patients having poor, moderate, or good quality of life (QoL) secondary to their incontinence problems. Data from two prospectively completed QoL questionnaires, the IIQ (n = 237) and the MOS 36-Item Short-Form Health Survey (SF-36) (n = 237), were analyzed using NN and conventional statistical tools. Kohonen networks identified three distinct clusters of IIQ scores. The three clusters represent the full spectrum of possible scores on the IIQ. We interpreted these clusters as reflecting good, moderate, and poor QoL. We estimated that a score of less than 50 on the IIQ would be representative of good QoL, between 50 and 70 would be moderate QoL, and greater than 70 would be indicative of poor QoL. Validation with the SF-36 data confirmed these categories. The present study demonstrated that the NN approach is opening new areas in the interpretation and clinical usefulness of QoL questionnaires. NN allowed the identification of three levels of QoL and should be useful in clinical decision making.

Data Interpretation, Statistical↗

PubMed2002

Normal variation and influence of stress, caffeine intake, and sexual activity on uroflowmetry parameters of a middle-aged asymptomatic cohort of volunteer male urologists.

AIMS: To assess normal variations of uroflowmetry in middle-aged asymptomatic male urologists and to analyse the influence of stress, caffeine intake, and sexual activity. METHODS: Thirty-one male urologists from Quebec and Ontario were recruited for this study. All were healthy, not taking any current medications known to interfere with lower urinary tract function, and symptom-free (International Prostate Symptom Score less than 5). Each received two identical flowmeters to keep over a period of 2 weeks, one at home and one in his busiest office. Ten uroflow tracings, with a volume greater than 150 mL, were requested from each of them; five at home and five in the office. A total of 310 flows were analysed. The subjective level of stress, coffee intake, and sexual activity, in the hour before each uroflowmetrogram, was recorded, through a short self-administered questionnaire and stress visual scale. RESULTS: are presented as an average per individual. The voided volume was 331.9 mL, with an SD of 94.8 mL. The voiding time was 32.7 seconds (SD=15.5). The peak flow rate was 20.5 mL/sec (SD=3.9), the mean flow rate was 14.3 mL/sec (SD=3.0), and the time to maximum flow was 7.2 sec (SD=4.0). Subjective levels of stress did not significantly change these parameters. Uroflows were obtained with and without coffee drinking. The voided volume was 337.4 mL (SD=109.2) vs. 290.8 mL (SD=77.3) (P=0.03), and peak flow rate 19.4 mL/sec (SD=4.1) vs. 18.9 mL/sec (SD=3.1) (P=0.49), respectively. CONCLUSIONS: Uroflowmetry parameters and voided volume are highly variable in a normal asymptomatic population. Subjective stress level does not seem to have an influence on these parameters. Coffee intake significantly increases the voided volume but does not change the peak flow rate. These conclusions should be considered when using uroflowmetry parameters as an outcome measure.

Adult↗

PubMed2002

A survey of physician efficacy requirements to plan clinical trials.

PURPOSE: Eliciting physician efficacy requirements for utilizing medical treatments can be a useful means of helping plan a clinical trial. Efficacy requirements were studied for female stress urinary incontinence, where an experimental treatment (collagen injection) was compared to the standard therapy (surgery). METHODS: A self-administered questionnaire was sent to 223 North American urologists, gynecologists, and urogynecologists. An interviewer also administered a similar questionnaire to 20 other clinician-specialists. RESULTS: The response rate for the self-administered questionnaire was 48.4% (108/223). All 20 clinician-specialists who were approached for an interview consented. On average, respondents to the self-administered questionnaire indicated they would consider using collagen as the first line treatment if the absolute reduction in efficacy of collagen versus surgery was no larger than 23%. The corresponding result for the interview-questionnaire was 22%. Efficacy was measured as patient satisfaction with treatment. In the opinion of the physicians, surgery would remain the standard therapy if the reduction was greater than 34% (self-administered questionnaire), or 37% (interviewer-administered questionnaire). CONCLUSIONS: The elicitation of physician efficacy requirements provides an idea of the treatment effect that would be needed for a clinical trial to have an impact on medical practice. These requirements can be used to calculate a relevant sample size.

Clinical Trials as Topic↗

PubMed2002

Quality of life assessment in men and women with urinary incontinence.

PURPOSE: The literature on assessment of quality of life from 1993 to 2001 was reviewed to evaluate and compare existing measures through their psychometric value and make adequate recommendations on their clinical use and future research. MATERIALS AND METHODS: We selected quality of life articles and abstracts from Current Content 1996 to 1997 and MEDLINE 1993 to 1996 for our first report presented at the first consultation on incontinence in Monaco in 1998. This report was then updated up to September 2001 using the same strategy. We made our recommendations based on our clinical and research experience with these tools. RESULTS: Several quality of life generic or disease specific questionnaires have been published for male and female urinary incontinence. However, their psychometric value is far from uniform and for most of them responsiveness is weak or has never been reported. CONCLUSIONS: Few quality of life questionnaires are at an advanced enough stage of development to be applied in clinical practice. However, even with these questionnaires more study remains to be done to make them shorter, sometimes even more specific and easier to use in different populations.

Female↗

PubMed2002

Endoluminal ureteroileal anastomosis.

PURPOSE: We present an alternative technique used to complete the ureteroileal anastomosis during the formation of an ileal conduit or neobladder. MATERIALS AND METHODS: Using an intraoperative camera to produce digital images and with the aid of computer graphics a visual and descriptive method was used to illustrate the technique. It involves eversion of the proximal ileal segment with exteriorization of the ileal mucosa. RESULTS: This technique allows for direct visualization of the mucosa-to-mucosa ureteroileal anastomosis. With normal tissues it does not require ureteral stents postoperatively. We have been performing this technique for the last 20 years and have never observed symptomatic urinary leakage. CONCLUSIONS: We present an alternative technique for completing the ureteroileal anastomosis with direct visualization and minimal morbidity.

Anastomosis, Surgical↗

PubMed2002

Assessment of clinical reasoning competence in urology with the script concordance test: an exploratory study across two sites from different countries.

OBJECTIVES: The script concordance (SC) test is designed to measure the organisation of knowledge that allows interpretation of data in clinical reasoning. This study explores the use of this new written examination tool in urology. MATERIALS AND METHODS: An 80 items SC test was administered to participants from a French and a Canadian university. Three levels of experience were tested: urologists (n = 22), residents in urology (n = 25) and students (n = 23). Scores between groups were compared by analysis of variance. Reliability analysis was studied with Cronbach alpha coefficient. RESULTS: Mean global scores were 51.45 +/- 5.29 for students, 58.19 +/- 3.81 for residents and 62.27 +/- 5.46 for urologists. The difference between the three groups was statistically significant (P < 0.00001). Interaction between levels of expertise and sites was apparently not significant (P = 0.326). Cronbach alpha was 0.79 for the test. CONCLUSIONS: This study shows that the SC test is able to discriminate among participants according to their levels of clinical experience in urology. The results are similar in two different learning environments. The SC test appears as a simple and direct approach to testing organisation and use of knowledge in urology.

Clinical Competence↗

PubMed2002

Stability of clinical reasoning assessment results with the Script Concordance test across two different linguistic, cultural and learning environments.

The Script Concordance (SC) test is designed to measure the organization of knowledge that allows interpretation of data in clinical reasoning. An originality of the test is that answer keys use an aggregate scoring method based on answers given by a panel of experts. Previous studies have shown that the SC test has good construct validity. This study, done in urology, explores (1) the stability of the construct validity of the test across two different linguistic and learning environments and (2) the effect of the use of experts who belong to different environments. An 80-item SC test was administered to participants from a French and a Canadian university. Two levels of experience were tested: 25 residents in urology (11 from the French university and 14 from the Canadian university) and 23 students (15 from the French faculty, eight from the Canadian faculty). Reliability analysis was studied with Cronbach's alpha coefficient. Scores between groups were compared by analysis of variance. Reliability coefficient of the 80 items test was 0.794 for the French participants and 0.795 for the Canadian participants. Scores increased with clinical experience in urology in the two sites. Candidates obtained higher scores when correction was done using the answer key provided by the experts from the same country. These data support the stability of the construct validity of the tool across different learning environments.

Adult↗

PubMed2002

Is an artificial sphincter the best choice for incontinent boys with Spina Bifida? Review of our long term experience with the AS-800 artificial sphincter.

OBJECTIVE: We describe our long-term experience in a uniform population of Spina Bifida boys all treated with the AS-800 model artificial urinary sphincter (AUS) and compare our results to other treatment modalities available to children with neurogenic incontinence. MATERIALS AND METHODS: The complete medical records of 30 patients with insertion of the AS-800 were reviewed. All were boys having Spina Bifida with only one having prior bladder neck reconstruction. The mean age at insertion was 12.6 years and the average follow up was 6.5 years. Anticholinergic agents and self-intermittent catheterization were used concomitantly to the AUS in 21 and 22 patients respectively. RESULTS: In our series, 19 (63%) patients were completely dry, 6 (20%) were slightly wet, 5 (17%) were incontinent. The mean lifetime of all artificial sphincters was 4.7 years with no statistically significant difference in survival of those inserted at the bladder neck and bulbar urethra (4.6 and 4.9 years respectively). However, a survival analysis revealed a sharp drop after 100 months with only 8.3% of the sphincters implanted lasting beyond this point. There were a total of 32 revisions performed in 17 patients constituting a 0.164 revision rate/patient-years. The other surgical treatment available to these children is bladder neck reconstruction with reported continence rates ranging from 61% to 76% at about 2 years follow up. CONCLUSIONS: In our experience, the AS-800 model artificial sphincter has a long term survival which rarely exceeds 8 to 9 years putting into question whether it or bladder neck reconstruction is the best long term solution for treating children with neurogenic incontinence. This question may be only answered by a randomized, controlled trial comparing these two modalities.

Adolescent↗

PubMed1999

Performance of the Incontinence Impact Questionnaire in Canada.

The Incontinence Impact Questionnaire (IIQ) was developed in the US and has been shown to be a valid and reliable measure of how urinary incontinence (UI) affects a woman's quality of life. This study aimed to test the performance of the IIQ in Canada with English and French-speaking Canadians. The IIQ underwent professional forwards-backwards translation and psychometric testing. Women (36 English and 34 French-speaking) consulting a urologist for stress urinary incontinence underwent routine multichannel urodynamic testing and completed the SF-36 and the IIQ. Test-retest reliability was moderate (ICC =.73) and each IIQ subscale demonstrated good internal consistency (a=.83 to.91). Moderate correlations between IIQ scores and number of pads/day and severity ratings support construct validity in both languages. In English, correlations with Physical and Social Functioning scales of the SF-36 were also moderate. The IIQ has demonstrated strong reliability and adequate validity with English-speaking Canadian women. Moreover, similar psychometric properties in both English and French provide evidence that the IIQ has been successfully translated into Canadian French.

Journal Article↗