Biomedical subjects

James C Overholser

Publications and source records attributed to James C Overholser.

8 recordsLinked to original sources

PubMed2006

Reduced glial and neuronal packing density in the orbitofrontal cortex in alcohol dependence and its relationship with suicide and duration of alcohol dependence.

BACKGROUND: Reduced metabolism, blood flow, and tissue volume have been detected in the dorsolateral prefrontal cortex (dlPFC) of neurologically intact alcoholic subjects and these deficits are accompanied by lower density of neurons and glial cells. Another prefrontal region, the orbitofrontal cortex (ORB), functionally and structurally differentiated from the dlPFC, and heavily involved in decision-making processes, also shows functional alterations in alcoholic subjects. However, it is unknown whether changes in the packing density of neurons or glial cells also occur in the ORB and whether that density may be related to the increased suicide probability of alcoholic subjects or to the duration of alcohol dependence. METHODS: The present study used a 3-dimensional cell-counting method in postmortem brain tissue to determine the packing density of neurons and glial cells in the ORB (area 47) of 15 subjects with alcohol dependence (8 suicides, 7 nonsuicides) and 8 normal controls and to determine whether cell density is correlated with suicide and duration of alcohol dependence. RESULTS: There was a significantly lower density of both neurons (by 27%) and glial cells (by 25%) in the ORB of alcoholic subjects compared with controls. Packing density of either neurons or glial cells was not significantly different in alcoholic suicides compared with alcoholic nonsuicides. Age was not correlated with neuronal or glial density in either group. However, the duration of alcohol dependence and the ratio of that duration to the length of life span were significantly and negatively correlated to the overall density of neurons. CONCLUSION: The present results indicate that alcohol dependence is associated with a decrease in the packing density of neurons and glia in the ORB and that the reduction in neuronal but not glial density progresses with the duration of alcohol dependence.

Adult↗

PubMed2004

Cellular changes in the postmortem hippocampus in major depression.

BACKGROUND: Imaging studies report that hippocampal volume is decreased in major depressive disorder (MDD). A cellular basis for reduced hippocampal volume in MDD has not been identified. METHODS: Sections of right hippocampus were collected in 19 subjects with MDD and 21 normal control subjects. The density of pyramidal neurons, dentate granule cell neurons, glia, and the size of the neuronal somal area were measured in systematic, randomly placed three-dimensional optical disector counting boxes. RESULTS: In MDD, cryostat-cut hippocampal sections shrink in depth a significant 18% greater amount than in control subjects. The density of granule cells and glia in the dentate gyrus and pyramidal neurons and glia in all cornv ammonis (CA)/hippocampal subfields is significantly increased by 30%-35% in MDD. The average soma size of pyramidal neurons is significantly decreased in MDD. CONCLUSION: In MDD, the packing density of glia, pyramidal neurons, and granule cell neurons is significantly increased in all hippocampal subfields and the dentate gyrus, and pyramidal neuron soma size is significantly decreased as well. It is suggested that a significant reduction in neuropil in MDD may account for decreased hippocampal volume detected by neuroimaging. In addition, differential shrinkage of frozen sections of the hippocampus suggests differential water content in hippocampus in MDD.

Adult↗

PubMed2003

Association of substance abuse and depression among adolescent psychiatric inpatients.

OBJECTIVE: To determine whether depression levels differ among suicide-attempting and non-suicide-attempting adolescent inpatients in relation to their alcohol use. METHOD: Ninety-eight adolescents hospitalized at a midwestern psychiatric hospital completed the Children's Depression Inventory and the Rutgers Alcohol Problem-Drinking Index (RAPI). Based on RAPI scores, adolescents were classified as heavy drinkers (n = 36) or light drinkers and nondrinkers (n = 62). RESULTS: Heavy drinkers had significantly more depression than those who were classified as light drinkers or nondrinkers regardless of suicide-attempting status. CONCLUSIONS: The results demonstrate a positive association between depression levels and problems with alcohol in adolescents, indicating that youth who both suffer from depression and abuse alcohol may be at higher risk for a suicide attempt.

Adolescent↗

PubMed2003

Predictors of attitudes towards physician-assisted suicide.

Psychological factors may influence an individual's acceptance of euthanasia and physician-assisted suicide (PAS). The purpose of the present investigation was to evaluate predictors of attitudes towards PAS. Data were collected from 136 college students at a private Midwestern university. In addition to demographic and family history information, respondents completed measures of attitudes toward seeking mental health services, depression, hopelessness, and PAS attitudes. Respondent age, race, and hopelessness scores emerged as the only significant predictors (R2=.20) in a multiple regression model used to identify potential predictors of PAS attitudes. Younger, non-minority respondents, and those enduring more hopelessness reported more accepting attitudes towards PAS. Data from a three month follow-up assessment supported the stability of this pattern. The findings highlight the important role that mental health professionals should play in PAS decision making. Implications for the evaluation of medically ill considering PAS and their caregivers are discussed.

Adolescent↗

PubMed2002

Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms.

BACKGROUND: Reductions in glial density and enlargement of glial nuclei have been reported in the dorsolateral prefrontal cortex (dlPFC) in mood disorders. In alcohol dependence, often comorbid with depression, it is unclear whether there are changes in the density and size of glial cells in the dlPFC. METHODS: The packing density and size of Nissl-stained glial cell nuclei were analyzed postmortem in the cortical layers of the dlPFC from 21 control and 17 alcohol-dependent (Alc) subjects without Wernicke or Korsakoff syndromes. Eight Alc subjects had depressive symptoms. The density of glial cells was measured with a three-dimensional cell counting method, and the areal fraction of glial fibrillary acidic protein immunoreactivity (GFAP) was also determined. RESULTS: Glial density was reduced by 11-14% in layers V and VI and in all layers combined in the Alc group. The size of glial nuclei was decreased by 3.2% in Alc subjects. The Alc subjects with depressive symptoms showed the lowest values of density and size. There was no difference in GFAP immunoreactivity, although the lowest values were in the Alc group. CONCLUSIONS: Alcohol dependence is characterized by decreases in both density and size of glia in the dlPFC. Glial pathology may be more severe in Alc subjects with depressive symptoms.

Adolescent↗

PubMed2002

Neurokinin-1 receptors are decreased in major depressive disorder.

Treatment with an antagonist at the neurokinin-1 (NK-1) receptor may alleviate depression, however the brain region(s) in which the NK-1 receptor antagonist exerts its therapeutic effect is unknown. [125I]BH-Substance P was used to measure NK-1 receptors postmortem in cytoarchitectonically defined areas of rostral orbitofrontal cortex (Brodmann's area 47) of subjects with major depressive disorder (n = 12, six females) and psychiatrically normal subjects (n = 11, five females). Six subjects with depression died by suicide. Subjects with depression showed decreased binding to NK-1 receptors across all cortical layers (p = 0.024). The pathophysiology of depression, and the reported therapeutic benefit of NK-1 receptor antagonists, may thus involve NK-1 receptors in prefrontal cortex.

Adult↗

PubMed2002

Depression, adult attachment, and recollections of parental caring during childhood.

The onset and course of depressive symptoms are influenced by a variety of interpersonal factors. Attachment theory provides a developmental framework for understanding the relationship between depressive symptoms and insecure attachment to one's parents and current romantic partner. The present study examined attachment theory for understanding depression and marital adjustment among 84 psychiatric inpatients diagnosed with major depressive disorder. Participants completed a diagnostic interview and self-report measures of depressive symptoms, adult attachment, marital adjustment, and recollections of childhood relationships with parents. Avoidant (but not anxious) adult attachment mediated the link between current depressive symptoms and patients' recollections of relationships with opposite-sex parents. Although nearly three fourths of the current sample of depressed psychiatric inpatients acknowledged the presence of marital problems, the negative correlation between depressive symptoms and marital adjustment did not reach statistical significance. Attachment theory may aid therapeutic approaches to depression within the context of marriage and other long-term romantic relationships.

Adaptation, Psychological↗

PubMed2002

Treatments for depression: wisdom imparted from treatments discarded.

Many different forms of treatment have been used with patients suffering from depression. It can be difficult to examine current treatments and anticipate problems, mistakes, and limitations. However, a historical perspective allows an appreciation of the strengths and limitations of older treatments, and sheds light on current strategies. A variety of effective treatments have been discarded and forgotten. Important lessons can be learned by reviewing the history of treatments for depression. Many treatment strategies were based on accidental discovery, but nonetheless were found effective in reducing the symptoms of depression. Both case examples and group studies have documented the effectiveness of these older treatments. A review of discarded treatments reveals how a biological model can be limited in its ability to produce a lasting cure. Caution and skepticism are encouraged when innovative treatments are proposed.

Depressive Disorder↗