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Biomedical subjects

James Choi

Publications and source records attributed to James Choi.

6 recordsLinked to original sources
PubMed2006

Decrease in emergency department length of stay as a result of triage pulse oximetry.

OBJECTIVES: Many emergency departments do not perform pulse oximetry in triage, in spite of its potential for altering management decisions. We attempted to quantify the decrease in patient throughput time in a pediatric emergency department following the introduction of triage pulse oximetry. METHODS: One hundred fifty-nine bronchiolitis patients from 2004 served as the preintervention group, and were evaluated against 89 severity-matched postintervention bronchiolitis patients from 2005. Their mean lengths of ED stay were compared by a t test. RESULTS: The preintervention group had a mean length of stay of 4 hours and 59 minutes, and the postintervention group had a mean length of stay of 4 hours and 9 minutes, which was significantly different (P = 0.03). The sensitivity of respiratory distress on the triage exam for predicting hypoxia was fair (74%). CONCLUSIONS: Institution of triage pulse oximetry significantly decreases ED throughput times. Clinical exam alone is not a replacement for measurement of oxygen saturation.

Bronchiolitis↗
PubMed2005

A blinded assessment of radiographic criteria for atlanto-occipital dislocation.

STUDY DESIGN: Blinded comparison of 5 methods to diagnose atlanto-occipital dislocation (AOD) on plain radiographs and computerized tomography (CT) of the cervical spine. OBJECTIVE: To determine the best method to diagnose AOD. SUMMARY OF BACKGROUND DATA: Several methods are proposed for the diagnosis of AOD, including the Power's ratio, X-line method, basion-dens interval, condylar gap, and Harris method. No blinded comparison of the results of these methods has been compared to patient outcome, and there is no information available regarding the accuracy of these methods applied to CT scans. METHODS: Plain lateral radiographs and CTs of the cervical spine were reviewed in 104 patients, including 6 with AOD. Images underwent a blinded review by a board certified neurosurgeon (D.K.R.), orthopedist (P.A.A.), radiologist (J.C.), and emergency physician (D.B.B.). Each diagnostic method for AOD was applied for determination of sensitivity, specificity, and positive and negative predictive values. The ability to identify relevant anatomic landmarks was also tabulated. RESULTS: Average values for sensitivities, specificities, positive and negative predictive values for each method applied to plain radiographs are: 0.4625-1.0, 0.8933-0.9725, 0.2775-0.45, and 0.975-1.0, respectively. These values for each method applied to CT scans are: 0.7075-1.0, 0.8725-0.9775, 0.3175-1, and 0.98-1.0, respectively. Identification of relevant anatomic landmarks occurred 99.75% of the time when these methods were applied to CT scans compared to 39% to 84% of the time on plain radiographs. CONCLUSIONS: Sensitivity, specificity, positive and negative predictive values of these methods improve when applied to CT scans because of better visualization of anatomic landmarks. This result suggests CT scans of the cervical spine may be warranted in all trauma patients suspected of having cervical spine injury.

Atlanto-Occipital Joint↗
PubMed2004

Carboplatin desensitization.

BACKGROUND: IgE-mediated carboplatin hypersensitivity reactions occur in up to 30% of patients receiving this agent for chemotherapy of solid tumors, thus limiting therapeutic options. OBJECTIVE: To describe our experience with intravenous carboplatin desensitization regimens, which culminated in a standardized, successful protocol for safe administration. METHODS: Eight consecutive patients with ovarian cancer who had experienced severe anaphylactic reactions to carboplatin were referred to our hospital. Intradermal skin testing was performed by raising a 3-mm bleb by injection of undiluted carboplatin at 10 mg/mL, and the wheal size was read at 20 minutes. The outcomes of the various desensitization regimens were documented prospectively, and the experience gained was used to develop a standardized protocol for administration. RESULTS: All patients had positive intradermal skin test results. The first 3 patients were treated with short (90 minutes to 6 hours) desensitization protocols, and all protocols failed on the first or second infusions. These 3 and a subsequent 5 patients were given intravenous carboplatin according to a protocol of gradual dose escalation over a 4-log dose range given during a 4-day period, with subsequent 3-weekly infusions given more rapidly by omitting the most dilute log dose on each occasion. All patients tolerated the longer infusion protocol without event, and all but 1 patient experienced appropriate tumor marker response. CONCLUSIONS: Short carboplatin desensitization protocols (less than 6 hours) have an unacceptable failure rate in patients with carboplatin allergy, but longer infusion times (days) are well tolerated without recurrence of the allergic reaction and with good tumor response. In cases where carboplatin is the optimal therapeutic agent, clinicians should not be deterred by an anaphylactic reaction to it or by failure of shorter desensitization regimens.

Aged↗
PubMed2002

Is the higher prevalence of benign prostatic hyperplasia related to lower urinary tract symptoms in Korean men due to a high transition zone index?

OBJECTIVE: Asian men generally have smaller prostate gland sizes than their Western counterparts. Nonetheless, the prevalence of lower urinary tract symptoms (LUTS) is similar between native Asian men and men in the Western hemisphere. The purpose of this study was to determine if the enlargement of the transition zone volume (TZV) relative to the overall prostate volume (PV) might account for the prevalence of LUTS among Korean men despite having "smaller" prostates. METHODS: Three hundred and seventy consecutive age-matched men (94 Caucasian, 94 Hispanic, 93 African-American, and 89 Korean) with LUTS were evaluated utilizing the International Prostate Symptom Score (IPSS), peak flow rate (Q(max)), serum PSA and transrectal ultrasound (TRUS). The ratio of TZV to total PV was used to determine the transition zone index (TZI). RESULTS: Mean baseline IPSS and Q(max) were significantly different (p<0.001 and p<0.03) for Korean men (19.9+/-7.6 and 11.3+/-4.2) in comparison to African-American (14.6+/-3.7, 12.6+/-4.1), Caucasian (13.4+/-4.3, 12.5+/-3.8), and Hispanic (13.9+/-3.1, 11.9+/-4.5) men. Regardless of race, TZI correlated with IPSS (r=0.31, p<0.01) and Q(max) (r=0.26, p<0.04). Mean TZI was significantly (p<0.001) higher in Korean and African-American men (0.45+/-0.08 and 0.44+/-0.05, respectively) than Caucasian and Hispanic men (0.39+/-0.03 and 0.38+/-0.02, respectively). CONCLUSIONS: Among age-matched, ethnically diverse men with moderate to severe LUTS, Korean men demonstrated more clinical symptoms and a higher ratio of transition zone enlargement relative to total prostate in comparison to Caucasian, Hispanic, and African-American men. The clinical significance of these findings remains to be determined.

Analysis of Variance↗
PubMedDate not supplied

Imaging of wrist masses.

The wrist is a complex structure with an extensive differential diagnosis for a presenting mass. However, the vast majority of hand and wrist masses are benign, and many of these have a distinctive radiographic appearance. In this article, the imaging characteristics of the most common entities are reviewed with particular attention to magnetic resonance appearance. The 3 most common hand and wrist lesions include ganglion cysts, giant cell tumors of the tendon sheath, and hemangiomas. Other common lesions that can be diagnosed radiographically include lipomas, neural sheath tumors, infection and inflammation, and variant soft-tissue or bony structures. The appearance of the fibrolipomatous hamartoma will also be demonstrated because this is a radiographically distinctive, though rare, lesion.

Abscess↗