Biomedical subjects

Jan Degryse

Publications and source records attributed to Jan Degryse.

4 recordsLinked to original sources

PubMed2006

Spirometry and smoking cessation advice in general practice: a randomised clinical trial.

RATIONALE: To assess the success rate of smoking cessation with the "minimal intervention strategy" in general practice, and to determine the influence of spirometry on this success rate. METHODS: Training in smoking cessation advice was given to 16 general practitioners (GPs). During 12 weeks, these GPs screened their practice population for smoking habits, the degree of dependence on nicotine, and the motivation to quit smoking. Patients willing to stop were randomised to a group that underwent a single office spirometry, or to a control group. The GPs were asked to support the attempts with the minimal intervention strategy. Success rates were compared after 6, 12 and 24 months. RESULTS: On a population of 5590 patients, 1206 smokers were identified (22%). To the vulnerable group, identified following the Prochaska and Di Clemente scheme, the proposal was made to change smoking behaviour. Two hundred and twenty-one patients undertook an attempt of smoking cessation. Nicotine replacement therapy (NRT) or bupropion was prescribed in 51% of the attempts. Sixty-four sustained quitters were counted after 6 months (29%), 43 after 1 year (19%) and 33 after 2 years (15%). We found a small but statistically non-significant difference in success rate in favour of the group that underwent office spirometry. CONCLUSION: GPs can motivate almost 20% of their smoking population to quit smoking. The success rate with the minimal intervention strategy was 19% after 1 year and 15% after 2 years. We found no arguments in favour of confronting smokers with their lung function as a tool for enhancing smoking cessation.

Adolescent↗

PubMed2004

A computerized adaptive knowledge test as an assessment tool in general practice: a pilot study.

Advantageous to assessment in many fields, CAT (computerized adaptive testing) use in general practice has been scarce. In adapting CAT to general practice, the basic assumptions of item response theory and the case specificity must be taken into account. In this context, this study first evaluated the feasibility of converting written extended matching tests into CAT. Second, it questioned the content validity of CAT. A stratified sample of students was invited to participate in the pilot study. The items used in this test, together with their parameters, originated from the written test. The detailed test paths of the students were retained and analysed thoroughly. Using the predefined pass-fail standard, one student failed the test. There was a positive correlation between the number of items and the candidate's ability level. The majority of students were presented with questions in seven of the 10 existing domains. Although proved to be a feasible test format, CAT cannot substitute for the existing high-stakes large-scale written test. It may provide a reliable instrument for identifying candidates who are at risk of failing in the written test.

Algorithms↗

PubMed2004

Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study.

STUDY OBJECTIVES: To determine if spirometry is essential for the early detection of COPD in general practice, compared to the screening value of a short questionnaire. METHODS: A prospective survey of the population aged 35 to 70 years visiting their general practitioner (GP) during a 12-week period, using a questionnaire on symptoms of obstructive lung disease (OLD). Spirometry was performed in all participants with positive answers and in a 10% random sample from the group without complaints. Twenty GPs were provided with a hand-held spirometer, and received training in performance and interpretation of lung function tests. All 35- to 70-year-old patients (n = 3,408) were screened for current use of bronchodilators. The subgroup receiving bronchodilators (n = 250, 7%) was assumed to have OLD, and was excluded. Airflow obstruction was defined according to the European Respiratory Society standards. RESULTS: The positive predictive power of the questionnaire was low (sensitivity, 58%; specificity, 78%; likelihood ratio, 2.6). One hundred twenty-six cases of formerly unknown OLD were detected in the group of patients with complaints, vs an extrapolated number of 90 in the group without complaints. Despite a negative predictive value of 95% for the questionnaire used, 42% of the newly diagnosed cases of OLD would not have been detected without spirometry. CONCLUSIONS: The use of a spirometer is mandatory if early stages of OLD are to be detected in general practice. Screening for airflow obstruction almost doubles the number of known patients with OLD.

Adult↗

PubMed2004

Cardiovascular prevention in general practice: development and validation of an algorithm.

OBJECTIVE: General practice visits are a unique opportunity to identify and treat individuals with a high cardiovascular (CV) risk. However, a case-finding strategy suited to the daily general practice is not provided in the CV prevention guidelines. We wanted to create, validate and test an algorithm for global CV risk assessment and management. METHODS: The algorithm was 1) developed based on evidence from epidemiological studies and clinical trials, 2) validated in a population-based cohort and 3) tested by randomly selected general practitioners (GPs) who rated its usefulness and applicability. RESULTS: 1) Screening for seven clinical risk factors (RF) allowed a quick classification of patients in four CV risk typologies: obvious high risk (previous CV event and/or type 2 diabetes) in 17%, obvious low risk (no RF) in 14%, smoking-related risk (single RF) in 6%, or undetermined risk (any other RF) to further evaluate in 63% patients. Inter-physician reproducibility for risk prediction was excellent. Overall, predicted risk was high, moderate and low in 25, 17 and 58% of the patients, respectively. 2) These risk predictions were validated in a cohort of 962 men followed over 10 years. 3) Most GPs reported that the algorithm was applicable and useful, while half of them started using it frequently in their daily practice. CONCLUSION: This algorithm is a new, pragmatic and evidence-based strategy for systematic and global CV risk management. It was validated at the population level, and shown to be applicable and useful in the daily general practice.

Adult↗