Biomedical subjects

Jan Wouters

Publications and source records attributed to Jan Wouters.

At least 19 recordsLinked to original sources

PubMed2007

A dual-process integrator-resonator model of the electrically stimulated human auditory nerve.

A phenomenological dual-process model of the electrically stimulated human auditory nerve is presented and compared to threshold and loudness data from cochlear implant users. The auditory nerve is modeled as two parallel processes derived from linearized equations of conductance-based models. The first process is an integrator, which dominates stimulation for short-phase duration biphasic pulses and high-frequency sinusoidal stimuli. It has a relatively short time constant (0.094 ms) arising from the passive properties of the membrane. The second process is a resonator, which induces nonmonotonic functions of threshold vs frequency with minima around 80 Hz. The ion channel responsible for this trend has a relatively large relaxation time constant of about 1 ms. Membrane noise is modeled as a Gaussian noise, and loudness sensation is assumed to relate to the probability of firing of a neuron during a 20-ms rectangular window. Experimental psychophysical results obtained in seven previously published studies can be interpreted with this model. The model also provides a physiologically based account of the nonmonotonic threshold vs frequency functions observed in biphasic and sinusoidal stimulation, the large threshold decrease obtained with biphasic pulses having a relatively long inter-phase gap and the effects of asymmetric pulses.

Auditory Threshold↗

PubMed2007

Speech understanding in background noise with the two-microphone adaptive beamformer BEAM in the Nucleus Freedom Cochlear Implant System.

OBJECTIVE: This paper evaluates the benefit of the two-microphone adaptive beamformer BEAM in the Nucleus Freedom cochlear implant (CI) system for speech understanding in background noise by CI users. DESIGN: A double-blind evaluation of the two-microphone adaptive beamformer BEAM and a hardware directional microphone was carried out with five adult Nucleus CI users. The test procedure consisted of a pre- and post-test in the lab and a 2-wk trial period at home. In the pre- and post-test, the speech reception threshold (SRT) with sentences and the percentage correct phoneme scores for CVC words were measured in quiet and background noise at different signal-to-noise ratios. Performance was assessed for two different noise configurations (with a single noise source and with three noise sources) and two different noise materials (stationary speech-weighted noise and multitalker babble). During the 2-wk trial period at home, the CI users evaluated the noise reduction performance in different listening conditions by means of the SSQ questionnaire. In addition to the perceptual evaluation, the noise reduction performance of the beamformer was measured physically as a function of the direction of the noise source. RESULTS: Significant improvements of both the SRT in noise (average improvement of 5-16 dB) and the percentage correct phoneme scores (average improvement of 10-41%) were observed with BEAM compared to the standard hardware directional microphone. In addition, the SSQ questionnaire and subjective evaluation in controlled and real-life scenarios suggested a possible preference for the beamformer in noisy environments. CONCLUSIONS: The evaluation demonstrates that the adaptive noise reduction algorithm BEAM in the Nucleus Freedom CI-system may significantly increase the speech perception by cochlear implantees in noisy listening conditions. This is the first monolateral (adaptive) noise reduction strategy actually implemented in a mainstream commercial CI.

Adult↗

PubMed2006

Effects of pulse rate on thresholds and loudness of biphasic and alternating monophasic pulse trains in electrical hearing.

Detection thresholds and most comfortable loudnesses (MCLs) were determined as a function of pulse rate for standard biphasic pulse trains (BP) and for anodic and cathodic monophasic phases alternating at fixed intervals (ALT-m). Three different phase durations were examined. With a 100-micros phase duration, thresholds for the ALT-m stimulus were substantially (up to 12 dB) lower than for the BP stimuli at relatively low rates (200 pps), but were similar to the BP thresholds at high rates (1000 pps). Thresholds for BP pulse trains decreased monotonically with increasing rate, whereas the function for ALT-m waveforms was non-monotonic with a maximum between 400 and 1000 pps. These trends occurred for three different cochlear implant devices, different electrode configurations, and, generally, for different phase durations (10.8, 25, and 100 micros/phase). However, at the shorter phase durations, thresholds remained lower for the ALT-m stimulus, even at 5000 pps, the highest rate studied. Dynamic ranges of the BP pulse trains increased with increasing rate, irrespective of the phase duration under test, but for the ALT-m stimuli this was only true at the shorter phase durations tested. At a 100-mus phase duration, dynamic ranges for the ALT-m waveforms did not differ significantly as a function of rate. The results confirm previous reports that delaying charge recovery, in this case by switching from a BP to an ALT-m wave shape, can substantially reduce thresholds [Van Wieringen, A., Carlyon, R.P., Laneau, J., Wouters, J., 2005. Effects of waveform shape on human sensitivity to electrical stimulation of the inner ear. Hear. Res. 200, 73-86; Carlyon, R.P., van Wieringen, A., Deeks, J.M., Long, C.J., Lyzenga, J, Wouters, J., 2005. Effect of inter-phase gap on the sensitivity of cochlear implant users to electrical stimulation. Hear. Res. 205, 210-224]. However, at high pulse rates, this advantage only occurs at short phase durations. In addition, we show that the complex interaction between the effects of pulse shape, rate, and phase duration on thresholds can be captured by the simple linear model described by Carlyon et al.

Adult↗

PubMed2006

Speech perception in preschoolers at family risk for dyslexia: relations with low-level auditory processing and phonological ability.

We tested categorical perception and speech-in-noise perception in a group of five-year-old preschool children genetically at risk for dyslexia, compared to a group of well-matched control children and a group of adults. Both groups of children differed significantly from the adults on all speech measures. Comparing both child groups, the risk group presented a slight but significant deficit in speech-in-noise perception, particularly in the most difficult listening condition. For categorical perception a marginally significant deficit was observed on the discrimination task but not on the identification task. Speech parameters were significantly related to phonological awareness and low-level auditory measures. Results are discussed within the framework of a causal model where low-level auditory problems are hypothesized to result in subtle speech perception problems that might interfere with the development of phonology and reading and spelling ability.

Adult↗

PubMed2006

Asymmetric pulses in cochlear implants: effects of pulse shape, polarity, and rate.

Existing cochlear implants stimulate the auditory nerve with trains of symmetric biphasic (BP) pulses. Recent data have shown that modifying the pulse shape, while maintaining charge balance, may be beneficial in terms of reducing power consumption, increasing dynamic range, and limiting channel interactions. We measured thresholds and most comfortable levels (MCLs) for various 99-pulses-per-second (pps) stimuli. "Pseudomonophasic (PS)" pulses consist of a brief phase of one polarity followed immediately by a longer and lower-amplitude phase of the opposite polarity. We focused on a novel variant of PS pulses, termed the "delayed pseudomonophasic (DPS)" stimulus, in which the longer phase is presented midway between the short phases of two consecutive pulses. DPS pulse trains produced thresholds that were more than 10 dB lower than those obtained with BP pulses. This reduction was much greater than the 0- to 3-dB drop obtained with PS pulses and was still more than 6 dB when a pulse rate of 892 pps was used. A study of the relative contributions of the two phases of DPS suggested that the short, high-amplitude phase dominated the perceived loudness. This study showed major threshold and MCL reductions using a DPS stimulus compared to the widely used BP stimulus. These reductions, which were predicted by a simple linear filter model, might lead to considerable power savings if implemented in a cochlear implant speech processor.

Adult↗

PubMed2006

Factors affecting the use of noise-band vocoders as acoustic models for pitch perception in cochlear implants.

Although in a number of experiments noise-band vocoders have been shown to provide acoustic models for speech perception in cochlear implants (CI), the present study assesses in four experiments whether and under what limitations noise-band vocoders can be used as an acoustic model for pitch perception in CI. The first two experiments examine the effect of spectral smearing on simulated electrode discrimination and fundamental frequency (FO) discrimination. The third experiment assesses the effect of spectral mismatch in an FO-discrimination task with two different vocoders. The fourth experiment investigates the effect of amplitude compression on modulation rate discrimination. For each experiment, the results obtained from normal-hearing subjects presented with vocoded stimuli are compared to results obtained directly from CI recipients. The results show that place pitch sensitivity drops with increased spectral smearing and that place pitch cues for multi-channel stimuli can adequately be mimicked when the discriminability of adjacent channels is adjusted by varying the spectral slopes to match that of CI subjects. The results also indicate that temporal pitch sensitivity is limited for noise-band carriers with low center frequencies and that the absence of a compression function in the vocoder might alter the saliency of the temporal pitch cues.

Acoustic Stimulation↗

PubMed2006

Horizontal localization with bilateral hearing aids: without is better than with.

This paper studies the effect of bilateral hearing aids on directional hearing in the frontal horizontal plane. Localization tests evaluated bilateral hearing aid users using different stimuli and different noise scenarios. Normal hearing subjects were used as a reference. The main research questions raised in this paper are: (i) How do bilateral hearing aid users perform on a localization task, relative to normal hearing subjects? (ii) Do bilateral hearing aids preserve localization cues, and (iii) Is there an influence of state of the art noise reduction algorithms, more in particular an adaptive directional microphone configuration, on localization performance? The hearing aid users were tested without and with their hearing aids, using both a standard omnidirectional microphone configuration and an adaptive directional microphone configuration. The following main conclusions are drawn. (i) Bilateral hearing aid users perform worse than normal hearing subjects in a localization task, although more than one-half of the subjects reach normal hearing performance when tested unaided. For both groups, localization performance drops significantly when acoustical scenarios become more complex. (ii) Bilateral, i.e., independently operating hearing aids do not preserve localization cues. (iii) Overall, adaptive directional noise reduction can have an additional and significant negative impact on localization performance.

Acoustic Stimulation↗

PubMed2005

Clinical application of dichotic multiple-stimulus auditory steady-state responses in high-risk newborns and young children.

Experience with dichotic multiple-stimulus auditory steady-state responses (ASSRs) in clinical practice is described. ASSR thresholds were assessed in a sample of 60 high-risk newborns and young children between birth and 4 years of age. Amplitudes and signal-to-noise ratios (SNRs) of the ASSR were compared between normal-hearing infants and adults. Age-related changes within a group of infants younger than 3 months of age were investigated. A comparison was made between ASSR, the click-evoked auditory brainstem response and behavioral hearing thresholds in infants with a wide range of hearing threshold levels. Mean ASSR thresholds for normal-hearing infants at an average corrected age of 12 days were 42 +/- 10, 35 +/- 10, 32 +/- 10 and 36 +/- 9 dB SPL for 0.5, 1, 2 and 4 kHz, respectively. Compared to adults, these thresholds were elevated by on average 11 dB and SNRs were 1.7 times smaller. However, based on ASSRs, reasonably accurate estimations could be made of behavioral hearing thresholds obtained at a later age (median delay of 7 months). The predicted thresholds were in 61% of the cases within 10 dB of the corresponding behavioral thresholds, and in 83% of the cases within 15 dB. In less than 1 h, thresholds at four frequencies per ear could be obtained. The optimal age of testing is between 1 week and 3 months corrected age. The dichotic multiple-stimulus ASSR technique is a valuable extension of the clinical test battery for hearing-impaired children, as a follow-up diagnostic after the neonatal hearing screening.

Adult↗

PubMed2005

Improved music perception with explicit pitch coding in cochlear implants.

Music perception and appraisal is very poor in cochlear implant (CI) subjects partly because (musical) pitch is inadequately transmitted by the current clinically used sound processors. A new sound processing scheme (F0mod) was designed to optimize pitch perception, and its performance for music and pitch perception was compared in four different experiments to that of the current clinically used sound processing scheme (ACE) in six Nucleus CI24 subjects. In the F0mod scheme, slowly varying channel envelopes are explicitly modulated sinusoidally at the fundamental frequency (F0) of the input signal, with 100% modulation depth and in phase across channels to maximize temporal envelope pitch cues. The results of the four experiments show that: (1) F0 discrimination of single-formant stimuli was not significantly different for the two schemes, (2) F0 discrimination of musical notes of five instruments was three times better with the F0mod scheme for F0 up to 250 Hz, (3) melody recognition of familiar Flemish songs (with all rhythm cues removed) was improved with the F0mod scheme, and (4) estimates of musical pitch intervals, obtained in a musically trained CI subject, matched more closely the presented intervals with the F0mod scheme. These results indicate that explicit F0 modulation of the channel envelopes improves music perception in CI subjects.

Adult↗

PubMed2005

Coherent motion detection in preschool children at family risk for dyslexia.

We tested sensitivity to coherent motion (CM) in random dot kinematograms in a group of 5-year-old preschool children genetically at risk for dyslexia, compared to a group of well-matched control children. No significant differences were observed, either in a group analysis or in an individual deviance analysis. Nonetheless, CM-thresholds were significantly related to emerging orthographic skills. In a previous study on the same subjects (Boets, Wouters, van Wieringen, & Ghesquière, in press), we demonstrated that both risk groups already differed on measures of phonological awareness and letter knowledge. Moreover, auditory spectral processing (especially 2 Hz FM detection) was significantly related to phonological ability. In sum, the actual visual and previous auditory data combined, seem to suggest an exclusive relation between CM sensitivity and orthographic skills on the one hand, and FM sensitivity and phonological skills on the other.

Child, Preschool↗

PubMed2005

Auditory temporal information processing in preschool children at family risk for dyslexia: relations with phonological abilities and developing literacy skills.

In this project, the hypothesis of an auditory temporal processing deficit in dyslexia was tested by examining auditory processing in relation to phonological skills in two contrasting groups of five-year-old preschool children, a familial high risk and a familial low risk group. Participants were individually matched for gender, age, non-verbal IQ, school environment, and parental educational level. Psychophysical thresholds were estimated for gap-detection, frequency modulation detection, and tone-in-noise detection using a three-interval forced-choice adaptive staircase paradigm embedded within a computer game. Phonological skills were measured by tasks assessing phonological awareness, rapid serial naming, and verbal short-term memory. Significant group differences were found for phonological awareness and letter knowledge. In contrast, none of the auditory tasks differentiated significantly between both groups. However, both frequency modulation and tone-in-noise detection were significantly related to phonological awareness. This relation with phonological skills was not present for gap-detection.

Child, Preschool↗

PubMed2005

A flexible auditory research platform using acoustic or electric stimuli for adults and young children.

A user-friendly and versatile research platform for use in auditory experiments, referred to as APEX (Application for PsychoElectrical eXperiments), is described. The platform takes care of automatic stimulus presentation and collection of the subject's responses. Acoustical auditory, as well as electrical auditory experiments with CI recipients can be conducted. The platform currently supports LAURA, Nucleus CI22 and Nucleus CI24 cochlear implants. The graphical user interface for the subjects has been extended to allow for testing very young children, by embedding the psychophysical procedures in a computer game. The research platform is available free of charge.

Acoustic Stimulation↗

PubMed2005

Effects of waveform shape on human sensitivity to electrical stimulation of the inner ear.

Psychophysical measures of the electrically stimulated human auditory system were obtained for different types of symmetric and asymmetric charge-balanced waveforms. Absolute detection thresholds of biphasic, pseudomonophasic, and 'alternating monophasic' current waveforms delivered by a bipolar intra-cochlear electrode pair were determined for four subjects implanted with the LAURA device. Thresholds for alternating monophasic stimuli, in which anodic and cathodic phases alternated every 5 ms, were 5-8 dB lower than for the biphasic waveforms for all four subjects. For two of the four subjects, thresholds for the pseudomonophasic waveforms were also significantly lower than for the biphasic waveforms. These pseudomonophasic thresholds were greatly affected neither by a 500-micros gap inserted between the two phases, nor by whether the shorter phase preceded or followed the longer one. Loudness balancing measures performed at the most comfortable levels also showed that, for equal loudness, alternating monophasic stimuli required a lower level than biphasic and pseudomonophasic waveforms. For three of the four subjects, the dynamic ranges of the pseudomonophasic (but not alternating monophasic) waveforms were greater than those of the biphasic waveforms. The results demonstrate that thresholds and dynamic ranges of human cochlear implant users can be controlled by manipulating the way in which the charge produced by the initial phase of an electrical pulse is recovered.

Adult↗

PubMed2005

Effect of inter-phase gap on the sensitivity of cochlear implant users to electrical stimulation.

Human behavioral thresholds for trains of biphasic pulses applied to a single channel of Nucleus CI24 and LAURA cochlear implants were measured as a function of inter-phase gap (IPG). Experiment 1 used bipolar stimulation, a 100-pps pulse rate, and a 400-ms stimulus duration. In one condition, the two phases of each pulse had opposite polarity. Thresholds continued to drop by 9-10 dB as IPG was increased from near zero to the longest value tested (2900 micros for CI24, 4900 micros for LAURA). This time course is much longer than reported for single-cell recordings from animals. In a second condition, the two phases of each pulse had the same polarity, which alternated from pulse to pulse. Thresholds were independent of IPG, and similar to those in condition 1 at IPG=4900 micros. Experiment 2 used monopolar stimulation. One condition was similar to condition 1 of experiment 1, and thresholds also dropped up to the longest IPG studied (2900 micros). This also happened when the pulse rate was reduced to 20 pps, and when only a single pulse was presented on each trial. Keeping IPG constant at 8 micros and adding an extra biphasic pulse x ms into each period produced thresholds that were roughly independent of x, indicating that the effect of IPG in the other conditions was not due to a release from refractoriness at sites central to the auditory nerve. Experiment 3 measured thresholds at three IPGs, which were less than, equal to, and more than one half of the interval between successive pulses. Thresholds were lowest at the intermediate IPG. The results of all experiments could be fit by a linear model consisting of a lowpass filter based on the function relating threshold to the frequency of sinusoidal electrical stimulation. The data and model have implications for reducing the power consumption of cochlear implants.

Action Potentials↗

PubMed2005

Comparison of MASTER and AUDERA for measurement of auditory steady-state responses.

Two approaches to assess auditory steady-state responses (ASSR) are compared under similar test conditions: a monaural single-frequency technique with a detection method based on phase coherence (AUDERA), and a binaural multiple-frequency technique using the F-test (MASTER). ASSR thresholds at four frequencies were assessed with both methods in both ears of ten normal-hearing and ten hearing-impaired adult subjects, within a test duration of one hour. The test-retest reliability and the influence of prolonging the test duration are assessed. For the total subject group the multiple-frequency technique outperforms the single-frequency technique. In hearing-impaired subjects, however, both techniques perform equally well. Hearing thresholds can be estimated with a standard error of the estimate between 7 and 12 dB dependent on frequency. About 55% of the estimates are within 5 dB of the behavioral hearing threshold, and 94% within 15 dB. Prolonging the test duration improves the performance of both techniques.

Acoustic Stimulation↗

PubMed2005

SVD-based optimal filtering for noise reduction in dual microphone hearing aids: a real time implementation and perceptual evaluation.

In this paper, the first real-time implementation and perceptual evaluation of a singular value decomposition (SVD)-based optimal filtering technique for noise reduction in a dual microphone behind-the-ear (BTE) hearing aid is presented. This evaluation was carried out for a speech weighted noise and multitalker babble, for single and multiple jammer sound source scenarios. Two basic microphone configurations in the hearing aid were used. The SVD-based optimal filtering technique was compared against an adaptive beamformer, which is known to give significant improvements in speech intelligibility in noisy environment. The optimal filtering technique works without assumptions about a speaker position, unlike the two-stage adaptive beamformer. However this strategy needs a robust voice activity detector (VAD). A method to improve the performance of the VAD was presented and evaluated physically. By connecting the VAD to the output of the noise reduction algorithms, a good discrimination between the speech-and-noise periods and the noise-only periods of the signals was obtained. The perceptual experiments demonstrated that the SVD-based optimal filtering technique could perform as well as the adaptive beamformer in a single noise source scenario, i.e., the ideal scenario for the latter technique, and could outperform the adaptive beamformer in multiple noise source scenarios.

Adult↗

PubMed2004

Multichannel place pitch sensitivity in cochlear implant recipients.

Cochlear implant recipients perceive a rise in pitch when the site of stimulation is moved from the apex toward the base. The place pitch sensitivity is typically measured using the stimulation of single channels. However, all current cochlear implant devices stimulate multiple channels simultaneously or with pulses temporally interleaved. The primary goal of the present study is to test whether the sensitivity of a cochlear implant recipient to changes in perceived pitch associated with changes of place of excitation improves or deteriorates when the number of active channels is increased, compared with stimulation with only one active channel. Place pitch sensitivity was recorded in four Nucleus CI24 subjects as a function of number of active channels (from 1 to 8). Just noticeable differences were estimated from a constant stimuli 2AFC pitch-ranking experiment with roving loudness. Reference and comparison stimuli contained the same number of active channels but were shifted one or two electrodes toward the base or toward the apex. The place pitch sensitivity was measured using monopolar stimulation at two locations along the electrode array. To minimize cues related to loudness, the multichannel stimuli were loudness balanced relative to the single-channel stimuli presented at C-level. The number of active channels did not affect place pitch sensitivity. This is consistent with a model that compares the edges of the excitation pattern irrespective of the overlap between excitation patterns. There was a significant difference in sensitivity to place pitch among subjects. The average just noticeable differences of place pitch, extrapolated from a fitting procedure, for the subjects ranged from 0.25 mm to 0.46 mm.

Acoustic Stimulation↗

PubMed2004

Objective assessment of frequency-specific hearing thresholds in babies.

OBJECTIVE: To report on clinical experience using dichotic multiple-stimulus auditory steady-state responses (ASSRs) as an objective technique to estimate frequency-specific hearing thresholds in hearing-impaired infants. METHODS: A comparison was made between the click-evoked auditory brainstem response (ABR), auditory steady-state responses and behavioral hearing thresholds (BHTs). Both ears of 10 infants between 3 and 14 months of age were tested. ABR and ASSRs were recorded during the same test session. ABR was evoked by 100 micros clicks. ASSRs were evoked by amplitude- and frequency-modulated tones with carrier frequencies of 0.5, 1, 2 and 4 kHz and modulation frequencies ranging from 82 to 110 Hz. Eight signals (four to each ear) were presented simultaneously. ASSR thresholds were derived after separate recordings of approximately 5, 7.5 and 10 min to compare the influence of test duration. BHTs were defined in later test sessions as soon as possible after the ASSR test, dependent on medical and developmental factors. RESULTS: For the subjects tested in this study 60% of ABR thresholds and 95% of ASSR thresholds for 1, 2 and 4 kHz were found at an average age of 7 months. Only 51% of frequency-specific BHTs could be obtained but on average 5 months later. The correlation of ABR thresholds and ASSR thresholds at 2 kHz was 0.77. The correlation of ASSRs and BHTs was 0.92. The mean differences and associated standard deviations were 4 +/- 14, 4 +/- 11, -2 +/- 14 and -1 +/- 13 dB for 0.5, 1, 2 and 4 kHz, respectively. The average test duration was 45 min for ABR (one threshold in both ears) and 58 min for ASSR (four thresholds in both ears). By reducing the duration of the separate recordings of ASSR, the precision of the hearing threshold estimate decreased and the number of outlying and missing values increased. Correlation coefficients were 0.92, 0.89 and 0.83 for recordings of maximum 10, 7.5 and 5 min, respectively. A compromise between test duration and precision has to be sought. CONCLUSIONS: Multiple-frequency ASSRs offer the possibility to estimate frequency-specific hearing thresholds in babies in a time-efficient way.

Adolescent↗