Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold.
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DNA↗
Biomedical subjects
Janarthanan Jayawickramarajah
Publications and source records attributed to Janarthanan Jayawickramarajah.
Synthesis and photophysics of a porphyrin-fullerene dyad assembled through Watson-Crick hydrogen bonding.
A novel porphyrin-fullerene dyad assembled through Watson-Crick hydrogen bonds is described; this system undergoes photoinduced electron transfer upon irradiation with visible light to produce a charge separated state that is substantially longer lived than that of previous dyads of this type.
Aniline Compounds↗
Functionalized base-pairs: versatile scaffolds for self-assembly.
This article discusses the development of synthetic supramolecular systems derived from hydrogen bond driven base-pairing, with a focus on the self-assembly of individual nucleobase analogues.
Base Pairing↗
Enhancing Hoogsteen interactions: a pyrrole-containing purine nucleoside that competes with guanosine self-assembly.
A pyrrole-appended purine nucleoside 1 is described that can form an "extended" three-point Hoogsteen-type interaction due to the stabilization of the donor-acceptor-acceptor (DAA) motif. Nucleoside 1 is shown to bind guanosine 10 (a classic ADD motif) to form ensemble I. This interaction competes effectively with guanosine self-assembly and, as such, is capable of disrupting guanosine quadruplex formation.
Binding, Competitive↗
Novel guanosine-cytidine dinucleoside that self-assembles into a trimeric supramolecule.
[reaction: see text] Synthesis and assembly studies of a guanosine-cytidine dinucleoside 1 that self-assembles into a trimeric supramolecule (I) are presented. Dinucleoside 1 was obtained by utilizing two consecutive palladium-catalyzed cross-coupling reactions. Ensemble I was analyzed by ESI-MS, NMR spectroscopies, size exclusion chromatography (SEC), and vapor pressure osmometry (VPO).
Chromatography, Gel↗