Increasing ciprofloxacin resistance in gonorrhoea.
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Biomedical subjects
Publications and source records attributed to Jane Morgan.
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Two cases of group A streptococcus (GAS) causing vulvovaginitis in premenopausal adults are described. A review of the literature of genital GAS is made, as this is an uncommon cause of vulvovaginitis in premenopausal adults. Contrasts are made between anogenital carriage of GAS and group B streptococcus (GBS) to highlight the differences in anogenital carriage between these two organisms.
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Changing lifestyles and dietary patterns over the last 20 years have conspired to increase a number of imbalances in the dietary patterns of the toddler population in the UK. The risk of the development of nutritionally-related diseases such as obesity and iron deficiency anaemia are a cause for concern. In this review, the paradox of falling levels of energy intake against a backdrop of rising levels of obesity is explored. New areas of research are highlighted, the findings of which have the potential to enhance the health and well-being of toddlers. Part 1 of the review considers current nutritional recommendations for toddlers and whether they are being met. Part 2, to be published in issue 15(3) of Journal of Family Health Care, will consider issues of particular concern, including the influence of contemporary lifestyles; dietary imbalances; obesity; and iron deficiency anaemia. Practical steps will be suggested to prevent obesity and iron deficiency anaemia.
Part 2 of a two-part review of toddler nutrition considers some current concerns, including the influence of changing lifestyles on dietary patterns; dietary imbalances; obesity; and iron deficiency anaemia. The review includes some practical steps to prevent obesity and iron deficiency anaemia.
OBJECTIVE: The impact of specific complementary foods on health outcomes has been poorly studied. We aimed to determine if meat consumption and breastfeeding influence growth and neurocognitive outcome in infants up to 24 months of age. METHODS: In a longitudinal cohort study, 144 full-term infants were recruited at 4 months. Their red and white meat consumption was recorded in sequential 7-day weighed food intake diaries at 4, 8, 12, 16, 20 and 24 months. Growth data were collected at the same census points as the dietary data. Neurocognitive outcome (psychomotor developmental indices and mental developmental indices) derived from the Bayley Scales of Infant Development II was measured at 22 months. RESULTS: Meat intake from 4-12 months was positively and significantly related to weight gain (P < 0.05); further analysis suggested this association might be mediated via protein intake but was independent of energy, zinc or iron intake. There was no interaction between meat intake and breastfeeding on growth. Meat intake from 4-12 and 4-16 months was positively and significantly related to psychomotor developmental indices (P < 0.02 and 0.013, respectively) but there was no association between breastfeeding and psychomotor developmental indices nor any interaction between meat intake and breastfeeding. Conversely, breastfeeding was positively and significantly related to mental developmental indices (P < 0.01) but there was no association between meat intake and mental developmental indices nor any interaction between breastfeeding and meat intake. These findings remained after adjustment for potential confounding factors. CONCLUSION: Meat intake, possibly via its effect on protein intake, is associated with increased weight gain in infants up to 12 months of age. Meat intake is also positively associated with psychomotor development at 22 months. These findings highlight the need for further investigation of the role of complementary foods in relation to health outcomes.
Nutrient insults in early pregnancy, such as nutrient deprivation during famines, are often associated with an unfavourable outcome. Suboptimal nutrition in the early stage of gestation has been linked to a number of adverse effects on fetal growth and development. Historically, nausea and vomiting in pregnancy (NVP) was an important contributor to pregnancy-related mortality; indeed, Charlotte Bronte died from starvation and dehydration after suffering very severe NVP 4 months into her first pregnancy (Gaskell, 1858). Although NVP seldom now progresses to be life-threatening, it affects the majority of pregnant women, and potentially presents a challenge to nutrient intake in the most vulnerable period of development. Symptoms range from mild (nausea only) to severe (a level of vomiting that restricts nutrient intake and ultimately threatens metabolic and electrolyte balance). Although NVP has been documented for thousands of years, its cause has not yet been satisfactorily elucidated, but seems to be related to endocrinological changes. Pregnant women also frequently report dietary cravings and aversions during pregnancy which can be linked to both the incidence and severity of NVP. Paradoxically, NVP appears to be positively associated with a favourable outcome of pregnancy, including increased birth weight and gestational age. The mechanisms by which NVP favours the outcome of pregnancy are not known. They may be related to women increasing their nutrient intake to alleviate symptoms, improving the quality of their diet or reducing energy expenditure. Alternatively, adaptation to a reduced nutrient intake might stimulate the expression of growth factors and affect placentation or metabolism, thus favouring fetal growth when NVP resolves.
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