Biomedical subjects

Janusz Kaczmarek

Publications and source records attributed to Janusz Kaczmarek.

4 recordsLinked to original sources

PubMed2005

[The sentinel node in cancer of the oral cavity, pharynx and larynx].

AIM OF THE STUDY: The evaluation of the importance of the prognostic of sentinel node biopsy in head and neck cancer with N0 neck. MATERIAL AND METHODS: Prospective study included 19 patients with squamous cell carcinoma of the oral cavity, pharynx and larynx without enlarged lymph nodes in ultrasound examination (N0). The study was carried out in ENT Department of Medical University in Poznań between 2001-2004. Each patient underwent lymphoscintigraphy after administration of radionuclide Technetium 99m (Nanocol). In case of detection of sentinel node, blue dye was injected into the tumour bed and dyed lymph nodes were removed. The specimens were evaluated histologically and immunohistochemically. The patients are still followed up. RESULTS: So far 19 patients were included in our study. The tumours were classified from T1 to T4. In each case sentinel nodes were located. Metastases in removed lymphnodes were found in 5 patients. In one of them regional recidive was observed after 5 month. In the other patients no changes were found in follow up examination. In 14 cases in histological examination no metastases were found in sentinel nodes. In this group in one case local recurrence was observed and in another two lymph nodes metastases were confirmed. In patients with positive sentinel node elective neck dissection was performed. So far immunohistochemical examination has not provided us with any vital information. In no case with negative sentinel node we found micrometastases with the use of cytokeratin. CONCLUSIONS: Based on our preliminary observation of the patients we have found that there is certain correlation confirming the fact that sentinel node may be reliable for the whole neck lymphatic system. Further clinical observation are needed based on a larger number of patients and longer observation period.

Aged↗

PubMed2002

[Multiple primary neoplasms on the face].

A case of 74-year old woman with six separate cancers is presented. Four of them were nonmelanoma skin cancers (2 basal-cell carcinomas and 2 squamous-cell carcinomas), the remaining two were noncutaneous malignancies (invasive lobular carcinoma of the breast and squamous cell carcinoma of the parotid gland). Three lesions were present simultaneously on the head and neck region; basal-cell carcinoma on the cheek, squamous-cell carcinomas on the forehead, and in the parotid gland. All neoplasms were surgically removed, the region of affected parotid gland was additionally radiated. Extreme rarity of the multifocal primary malignancies is emphasized and the non-completely clear etiology, biology and pathology of these tumors is discussed.

Aged↗

PubMed2002

[Sono-morphologic criteria of metastatic and reactive modes in the neck].

Real time high resolution ultrasonography (US) is thought to be the diagnostic tool of high sensitivity in detecting lymph nodes in patients diagnosed and follow-up for head and neck malignancies. Sensitivity and specificity of US are determined by quality of equipment, the kind of transducer and the experience of ultrasonographer. The diagnostic difficulties are met in small lymph nodes, less than 10 mm. Which sonographic picture is ambigious. It is very important in follow-up to avoid false-negative nodes and possibility of overtreatment of patient. The aim of the paper was to determine the sonomorphogic criteria which enable improving the specificity of neck ultrasonography especially in assessing the small, less then 10 mm lymph nodes. MATHERIAL AND METHOD: Ultrasonograph Aloka SSD 3500 and transducer 7.5 Mhz with 42 mm linear probe. The neck US was performed before the surgery. Maximal longitudinal diameter (L), maximal diameter (S), their ratio (S/L) which indicate the lymph node shape, echogenicity and internal echostructure were assessed. The features of the lymph node capsule, i.e. continuity, lost of echos were taken into consideration. The high echogenicity, the round shape of the node, lost of hilus central echo or it's marginal displacement correlate with malignant character of the node. Lost of echos in node capsule are not the indicator of the extracapsular spread. Using sonomorphologic criteria in assessment of small lymph nodes in the neck the authors stated the meaningful improving of US specificity.

Carcinoma, Squamous Cell↗

PubMed2002

[Prognostic significance of Ki 67 and PCNA expression in laryngeal squamous cell carcinoma (morphometric evaluation of labelling index-L1].

There are no certain histological or morphological criteria which would improve the precision of life expectancy and the selection of the most efficient methods of treatment in patients with squamous cell laryngeal carcinoma. The analysis of proliferation activity using immunohistochemical markers such as antigens Ki 67 and PCNA may be helpful to evaluate the aggressiveness of neoplastic cells. The study was conducted in 55 patients (aged 36-86 years, mean 62 years), 52 men and 3 women. Immunohistochemical staining of antigens Ki 67 and PCNA using avidin-biotin method was performed in all cases. Microscopic images were stored, then nuclei of neoplastic cells expressing immunohistochemical reaction were localized using level segmentation method. Next labelling index was calculated. The correlation was observed between the LI for Ki 67 and tumor size (p < 0.00001), stage (p < 0.001), metastases to lymph nodes (p, 0.00001) and site (p < 0.005). A weak correlation was observed between the LI for Ki 67 and presence of distant metastases (p < 0.06). The LI of neoplastic cells for PCNA was correlated with the tumor size (p < 0.00001), stage (p < 0.0001), metastases to lymph nodes (0.0001), site (p < 0.005) and presence of distant metastases (p < 0.03). On the ground of the obtained results both markers can be suggested for the morphological and biological evaluation of the neoplastic cells in laryngeal squamous cell carcinoma.

Adult↗