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Biomedical subjects

Janusz Kamiński

Publications and source records attributed to Janusz Kamiński.

8 recordsLinked to original sources

[Patient with haemoptysis, dyspnoea, fever and lung infiltration].

In this study we presented the case of 55 years old man who was admitted to the Dept. of Lung Diseases and Tuberculosis in Zabrze with haemoptysis, dyspnoea, fever and lung infiltration. Initially the neoplastic disease was diagnosed. From the information gathered from the patient's family it was stated that the patient has been taking acenocoumarol for a considerably long time without any professional supervision. In this study we emphasize the importance of motivating and informing patients about the purposefulness of control examinations while using this kind of drugs.

Acenocoumarol↗

[Invasive pulmonary aspergillosis as a complication of prolonged antibiotic therapy].

In this study we present the case of 53 year old woman hospitalized in the Department of Lung Diseases and Tuberculosis in Zabrze, Silesian Medical University in Katowice, due to chronic cough and infiltration in the chest radiogram. Prior to the admission, the patient received long-lasting antibiotic ambulatory treatment leveled at laryngobronchitis. After admission the patient underwent bronchofiberoscopy during which a sample for mycological examination of bronchoalveolar lavage was taken. The result of the examination made possible to give the diagnosis--invasive pulmonary aspergillosis. Proper antifungal treatment was used and in consequence considerable improvement in both clinical and radiological state was achieved. Invasive pulmonary aspergillosis is mostly diagnosed in immunocompromised patients. The patient described in this case had none risk factors. Based on that particular case we may state a hypothesis that a prolonged antibiotic therapy is an important risk factor of invasive pulmonary aspergillosis incidence.

Anti-Bacterial Agents↗

[Mucoepidermoid carcinoma of the lung--case reports].

Two patients, a young woman and a young man, with mucoepidermoid carcinoma of the lung, who were diagnosed at the Department of Phthisiopneumonology in Zabrze Silesian Medical University in Katowice are described. The principal method of diagnostics in the presented cases were bronchofiberoscopy followed by the histopathological examination of the lesions. There are no cases of massive bleeding as the side effect of this procedures described. This type of carcinoma of the lung is mostly found in young patients, usually without any risk factors of lung cancer, what confirms the rule, that all pulmonological symptoms of unknown origin should be verified by bronchoscopy, because other methods of diagnostics, including TC of chest-like in our patient, may be false-negative. The method of choice in the treatment of mucoepidermoid carcinoma is surgery. One should avoid a through bronchoscope resection, as it may be only partial. Metastases, mostly found in the local lymph nodes, are rarely described.

Adolescent↗

[Survey of bronchoscopy in the Pulmonology Centers of the Upper Silesian region in 2002. Part I. Doctor and patient].

The aim of the study is to present the up-to-date data concerning bronchoscopy in the Silesian region in the year 2002. The study was performed as a survey. The survey was mailed to all the 18 pulmonological centres in the silesian region. Questions included in the survey, were divided into three groups: Doctor, Patient, Performance. This article, which is the first part of the analysis, presents data concerning doctors and patients. We conclude, on the ground of the collected data, that there are differences in performing bronchoscopy in the analysed centres. It may result from the fact, that the practice is often guided by personal experience and some drugs and diagnostic procedures are not equally available. It seems to be necessary to perform prospective clinical studies in order to indicate the optimal procedures in bronchoscopy.

Attitude of Health Personnel↗

[Survey of bronchoscopy in the Pulmonology Centers of the Upper Silesian region in 2002. Part II. Performance].

The aim of the study is to present the up-to-date data concerning bronchoscopy in the Silesian region in the year 2002. The study was performed as a survey. The survey was mailed to all the 18 pulmonological centres in the silesian region. The questions included in the survey, were divided into three groups: Doctor, Patient, Performance. This article, which is the second part of the analysis, presents data concerning the Performance. We conclude, on the ground of the collected data, that there are differences in performing bronchoscopy in the analysed centres. It may result from the fact, that the practice is often guided by personal experience and some drugs and diagnostic procedures are not equally available. It seems to be necessary to perform prospective clinical studies in order to indicate the optimal procedures in bronchoscopy. One should also recommend to work up up-to-date instructions for the postgraduate training in the fields of bronchology.

Bronchoscopy↗

[Broncho-alveolar lavage cells are the most significant reservoir of human cytomegalovirus genome].

The aim of the study is to estimate human cytomegalovirus DNA copy number in different compartments (BAL cells, blood leukocytes, serum) in patients with idiopathic pulmonary fibrosis (IPF). There were 16 patients (mean age 40.87 +/-10.97; 9 males, 7 females) with newly diagnosed and so far not treated IPF included in the study. The diagnosis of IPF was confirmed by typical HRCT findings and/or lung biopsy histopathological examination (result of the biopsy: "usual interstitial pneumonia"). There were also 16 adult volunteers (mean age 36.75 +/- 6.43; 12 males, 4 females) included in the study as a control group. Using the real-time quantitative polymerase chain reaction the HCMV DNA copy number was estimated. The prevalence of HCMV DNA positive subjects in the IPF group (75%) was higher, but did not differ significantly from the control group (69%). The HCMV DNA copy number in 1 million BAL cells was significantly higher comparing to blood leukocytes, both in IPF and control group (log10 = 2.7 vs. 1.2 for IPF and 2.8 vs. 0.9 for control, respectively). Higher mean HCMV DNA copy number was observed in IPF patients comparing to control group (log10 = 3.2 for IPF and 2.0 for control) in 1 mL of blood serum. We concluded that the lungs play an important role in human cytomegalovirus latency and infection reactivation and thus could be a cofactor modulating the course of IPF in humans. The contribution of HCMV infection in IPF patients should be taken into account during immunosuppression therapy planning.

Adult↗

[Chronic obstructive pulmonary disease in inhabitants of Zabrze].

In 2001 a modified MRC questionnaire and spirometry were performed in the inhabitants of Zabrze (Poland). Two hundred and thirty-nine men and 320 women aged 19-69 years were studied. Forty percent of men and 23% of women were smokers. In men but not in women a decline in smoking habit was observed as compared with previous studies in Zabrze carried out in the eighties. More men (32%) than women (19%) gave up smoking. The prevalence of chronic productive cough was closely related to smoking habit. Dyspnea and wheezing were also related to smoking but less strongly than productive cough. The prevalence of COPD (diagnosed according to GOLD criteria) was 10.2%. COPD was more common in smokers than in non-smokers, especially among men (19% and 2% respectively). Persistent productive cough, wheezing and advanced dyspnoea as well as intensive smoking (more than 40 pack years) were strongly connected with the prevalence of COPD. COPD was previously diagnosed in more than 50% of subjects identified as having COPD in this study. Almost 80% of subjects with COPD were not given any treatment in the past year.

Adult↗