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Biomedical subjects

Javier Escrig-Sos

Publications and source records attributed to Javier Escrig-Sos.

6 recordsLinked to original sources
PubMed2006

[Diagnostic tests: basic concepts for their correct interpretation and use].

The present article aims to disseminate knowledge of a topic that is important in clinical epidemiology: evaluation of diagnostic tests. Mathematical formulae are kept to a minimum. The significance and interpretation of the most important diagnostic indexes characterizing these tests are explained in order to describe their use in daily clinical practice, especially their role in the design of diagnostic protocols. Features related to evidence-based medicine, which represent the next step after mastery of these concepts, are not analyzed.

Clinical Protocols↗
PubMed2006

[Bull horn wounds in Castellon General Hospital. A study of 387 patients].

UNLABELLED: Bull horn lesions are frequent in the Latin world due to spectacles involving these animals. These wounds have special characteristics that distinguish them from all other lesions. MATERIAL AND METHOD: A retrospective analysis of the medical records of patients with bull horn lesions admitted to our service between January 1978 and October 2005 was performed. RESULTS: A total of 387 patients with bull horn lesions were admitted to our service. There were 12 readmissions due to a new wound in a previously treated patient. Twenty-seven patients had two or more lesions. The location of the wounds was: head and neck in 12 (3.1%), thorax in 21 (5.4%), upper extremities in 19 (4.9%), abdomen in 44 (11.3%), perineum in 41 (10.5%), back and lumbar region in 6 (1.5%), and lower extremities in 244 (63%). Thirty-one laparotomies were performed and there were 23 visceral lesions. Surgical treatment in addition to specific procedures consisted of irrigation with antiseptic solution, Friedreich, and primary closure over drains. Antibiotic and antitetanus vaccinations were administered in all patients. The most frequent early complications were: wound devitalization (7 patients) and infection (6 patients). The most frequent late complication was incisional hernia. Three patients died as a result of hypovolemic shock, septic shock and gas gangrene. CONCLUSION: Bull horn wounds have special characteristics. Familiarity with these lesions is important in areas where bullfighting is practiced. Although bull horn wounds are severe, their prognosis is good, with few complications and a mortality rate of less than 1%.

Adolescent↗
PubMed2006

[Gastric cancer: probability assessment after lymph node-negative staging and its consequences].

OBJECTIVE: To provide an approach to calculating the probability of error after lymph node-negative staging in gastric cancer. PATIENTS AND METHOD: Retrospective data of 75 gastric resections for cancer were used to calculate the probability of error in general, according to T staging of the TNM classification (6th edition) and according to the type of lymphadenectomy performed. A modification of a procedure based on Bayes' theorem was used. RESULTS: For all tumors, at least 11 negative lymph nodes were required to ensure a true pN0. Two lymph nodes were required for T1 tumors, 11 for T2 tumors, and 14 for T3 tumors. A greater number of lymph nodes were required for a D2 lymphadenectomy than for a D1 lymphadenectomy. However, in D2 lymphadenectomy, pN0 stages were almost always reliable, while in D1 lymphadenectomy 24% of stagings were unreliable. CONCLUSIONS: The present study describes a simple and reproducible mathematical model that could help surgeons to determine the accuracy of lymph node-negative stages in a substantial group of patients with gastric cancer.

Bayes Theorem↗
PubMed2005

[On how to analyze the credibility of a clinical trial or meta-analysis whose main result is expressed in odds ratio, relative risk or hazard ratio].

Beyond the type of design or the statistical analysis applied, the credibility of a research study lies in the compatibility of its results with the intensity that the reader could accept that the phenomenon studied might have from a biological point of view. Ultimately this requires a value judgment. The present article describes a procedure that can be used to objectively approach the limits of intensity that that a biological phenomenon could have, according to the data presented, so that, based on the reader's judgment derived from the available knowledge of the problem, the study can be deemed credible. The procedure is valid when the results of the study are expressed in odds ratio, relative risk or hazard ratio. Although these statistics are difficult to interpret, they are probably the most widely used in clinical trials and meta-analyses, that is, in studies whose methodological designs provide the highest level of evidence.

Clinical Trials as Topic↗