[Fibrotest: epistemological evolution and ethical breakthrough].
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Diagnostic Techniques, Digestive System↗
Biomedical subjects
Jean-Marc Combis
Publications and source records attributed to Jean-Marc Combis.
[Assessment of quality of life in chronic hepatitis C: effect of treatment].
OBJECTIVES: To study Quality of Life during chronic hepatitis C infection in patients recruited by hospital-based- or private hepatologists and to assess the effect of antiviral therapy. METHODS: A self-administered quality of life questionnaire (SF36) was proposed before, during, and 6 months after the end of treatment. The quality of life scales were assessed according to treatment response. RESULTS: 599 patients filled in the questionnaire before treatment and 168 patients 6 months after the end of treatment. After 6 months of therapy, patients with treatment response (n=54) showed increased scores in all SF-36 scales, this increase reaching more than 25% for "Role Physical", "General Health Perception" and "Vitality" scores. Non-responders (n=70) had an impairment of physical scores but a general improvement of Mental Health. CONCLUSION: This study confirms that sustained virological response is associated with an improved quality of life in hepatitis C patients. However, non-responders still have a positive "General Health Perception". Together with the development of new therapies, these observations could help to convince reluctant patients to be treated.
Adult↗