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Biomedical subjects

Jean-Paul Beregi

Publications and source records attributed to Jean-Paul Beregi.

At least 19 recordsLinked to original sources
PubMed2006

Fibromuscular dysplasia of the main renal arteries: comparison of contrast-enhanced MR angiography with digital subtraction angiography.

PURPOSE: To retrospectively evaluate the sensitivity and specificity of contrast material-enhanced magnetic resonance (MR) angiography by using digital subtraction angiography as the reference standard in patients with hypertension and renal artery fibromuscular dysplasia (FMD). MATERIALS AND METHODS: Institutional review board approval was obtained, with waiver of informed consent. The results of renal contrast-enhanced MR angiography were retrospectively analyzed in 25 patients with hypertension (24 women, one man; mean age, 48 years +/- 19 [standard deviation]; age range, 18-72 years) who had FMD diagnosed on the basis of clinical and angiographic features. All examinations were performed at 1.5 T. Results were analyzed by two readers, and a third reader established a consensus in case of discrepancy. Sensitivity, specificity, and 95% confidence intervals (CIs) were calculated for FMD and for each possible type of FMD lesion ("string of pearls" appearance, stenosis, and aneurysm). A linear-weighted kappa statistic was calculated to determine agreement between digital subtraction angiography and contrast-enhanced MR angiography for the diagnosis of FMD and to determine inter- and intraobserver agreement regarding FMD diagnosis. RESULTS: Fifty main renal arteries were analyzed, 35 of which demonstrated abnormal arteriographic features of FMD (stenosis, 22 arteries; string of pearls, 21 arteries; and aneurysm, four arteries). The sensitivity and specificity of contrast-enhanced MR angiography for the diagnosis of FMD were 97% (95% CI: 83%, 100%) and 93% (95% CI: 66%, 100%), respectively. Sensitivity was 68% (95% CI: 83%, 100%), 95% (95% CI: 74%, 100%), and 100% (95% CI: 40%, 100%) for the diagnosis of stenosis, string of pearls, and aneurysm, respectively. Linear-weighted kappa statistics for inter- and intraobserver agreement regarding FMD diagnosis were 0.63 and 0.92, respectively. CONCLUSION: In patients with renal FMD, contrast-enhanced MR angiography can reliably facilitate diagnosis by demonstrating characteristic lesions.

Adolescent↗
PubMed2006

Results of endovascular repair of the thoracic aorta with the Talent Thoracic stent graft: the Talent Thoracic Retrospective Registry.

BACKGROUND: Endovascular treatment of thoracic aortic diseases demonstrated low perioperative morbidity and mortality when compared with conventional open repair. Long-term effectiveness of this minimally invasive technique remains to be proven. The Talent Thoracic Retrospective Registry was designed to evaluate the impact of this therapy on patients treated in 7 major European referral centers over an 8-year period. METHODS: Data from 457 consecutive patients (113 emergency and 344 elective cases) who underwent endovascular thoracic aortic repair with the Medtronic Talent Thoracic stent graft (Medtronic/AVE, Santa Rosa, Calif) were collected. Follow-up analysis (24 +/- 19.4 months, range 1-85.1 months) was based on clinical and imaging findings, including all adverse events. To ensure consistency of data interpretation and event reporting, one physician reviewed all adverse events and deaths for the whole cohort of patients. In the case of discrepancies, the treating physicians were queried. FINDINGS: Among 422 patients who survived the interventional procedure (in-hospital mortality 5%, 23 patients), mortality during follow-up was 8.5% (36 patients), and in 11 of them the death was related to the aortic disease. Persistent endoleak was reported at imaging follow-up in 64 cases: 44 were primary (9.6%) and 21 occurred during follow-up (4.9%). Seven patients with persistent endoleak had aortic rupture during follow-up, at a variable time from 40 days to 35 months, and all subsequently died. A minor incidence of migration of the stent graft (7 cases), graft fabric alteration (2 cases), and modular disconnection (3 cases) was observed at imaging. Kaplan-Meier overall survival estimate at 1 year was 90.97%, at 3 years was 85.36%, and at 5 years was 77.49%. At the same intervals, freedom from a second procedure (either open conversion or endovascular) was 92.45%, 81.3%, and 70.0%, respectively. CONCLUSION: Endovascular treatment for thoracic aortic disease with the Talent stent graft is associated with low early morbidity and mortality rates also for patients who are at high risk and treated on an emergency basis. Follow-up data indicate a substantial durability of the procedure with a high freedom from related death and secondary interventions.

Adult↗
PubMed2006

Midterm results of aortic diameter outcomes after thoracic stent-graft implantation for aortic dissection: a multicenter study.

PURPOSE: To evaluate aortic diameter outcomes after stent-graft implantation for aortic dissection in the descending thoracic aorta. METHODS: Fifty patients with type A dissection after ascending aortic surgery (n = 10), type B dissection (n = 34), or intramural hematoma (n = 6) underwent stent-graft repair in 3 centers. Thrombosis and aortic diameter were analyzed by computed tomographic angiography at different levels of the aorta before stent-graft implantation, at discharge, and at follow-up. Measurements were standardized. RESULTS: In all, 67 stent-grafts were implanted for acute (n = 18) and chronic (n = 32) dissection. Stent-graft placement was successfully performed with high technical success (100%) despite 4 major complications (iliac thrombosis in 2 cases, aortic rupture, and a type A dissection) in 3 (6%) patients. Complete thrombosis of the thoracic false lumen was observed in 42% and 63% of cases at discharge and at follow-up (mean 15 months), respectively. At follow-up, the diameters of the entire aorta (mean 5 mm, p < 0.05) and the false lumen (mean 11 mm, p < 0.0001) decreased. Diameters of the abdominal aorta remained stable in association with persistent false lumen perfusion at this level. Aortic diameter results were better in the subgroup of patients with intramural hematoma compared to patients with Marfan syndrome. Three early deaths unrelated to the stent-graft procedure occurred; 2 patients with partial thrombosis of the false lumen died in follow-up secondary to aortic diameter growth. CONCLUSION: Complete thrombosis of the false lumen by stent-graft coverage of the entry tear results in decreased diameter of the entire aorta. In patients with partial thrombosis of the false lumen, the aneurysm continues to enlarge.

Adult↗
PubMed2006

Multislice computed tomographic angiography versus digital subtraction angiography in the follow-up of nitinol stents in the superficial femoral artery.

PURPOSE: To compare quantitative and qualitative parameters obtained from digital subtraction angiography (DSA) with multislice computed tomographic angiography (MSCTA) in the follow-up of superficial femoral artery (SFA) stents. METHODS: Thirteen patients who had SMART stents implanted in the SFA were examined systematically with DSA and MSCTA (16-row scanner) at 6 months. Quantitative analysis and morphological assessment were performed on DSA images by an independent core laboratory, while the MSCTA images were analyzed by 2 radiologists in consensus. DSA measurements included stent length, minimal lumen diameter and reference diameter at mid stent and 5 mm either side of the stent, and percentage of stenosis. For MSCTA images, lumen area and the minimum, maximum, and mean diameters were also recorded. The images were analyzed qualitatively for diameter stenosis (<50%, 50% to 70%, 71% to 99%, and occlusion), bends, fractures, and calcifications. RESULTS: There were no statistical differences between lengths of stented segments, diameter measurements, or percentages of stenosis from DSA and MSCTA images. The Bland-Altman method showed good agreement between the 2 methods of measurement. MSCTA detected in-stent proliferation with a diameter stenosis <50% in all 13 cases diagnosed on DSA (there was no stenosis >50%). There were no bends or stent fractures on either set of images. The agreement between DSA and MSCTA for the presence and grading of calcifications was moderate (kappa=0.5). CONCLUSION: MSCTA provided quantitative and qualitative data comparable with DSA in the analysis of SFA nitinol stents.

Aged↗
PubMed2006

Drug-eluting and bare nitinol stents for the treatment of atherosclerotic lesions in the superficial femoral artery: long-term results from the SIROCCO trial.

PURPOSE: To review clinical outcomes of patients with chronic limb ischemia and TASC type C lesions treated with sirolimus-eluting versus bare SMART nitinol self-expanding stents. METHODS: Data were obtained from a randomized, multicenter, double-blinded study conducted in 2 phases. All 93 patients had chronic limb ischemia and superficial femoral artery (SFA) occlusions or stenoses (average lesion length 8.3 cm). In total, 47 patients (31 men; mean age 66.3+/-9.1 years, range 50-84) received the sirolimus-eluting SMART stent and 46 patients (36 men; mean age 65.9 +/-10.8 years, range 38-83) received a bare SMART nitinol stent. Both groups were followed for a mean 24 months. RESULTS: Both the sirolimus-eluting and the bare SMART stents were effective in revascularizing the diseased SFA and in sustaining freedom from restenosis. For both types of stents, improvements in ankle-brachial indices (ABI) and symptoms of claudication were maintained over 24 months (median 24-month ABI 0.96 for the sirolimus group versus 0.87 for the bare stent group, p>0.05). At 24 months, the restenosis rate in the sirolimus group was 22.9% versus 21.1% in the bare stent group (p>0.05). The cumulative in-stent restenosis rates according to duplex ultrasound were 4.7%, 9.0%, 15.6%, and 21.9%, respectively, at 6, 9, 18, and 24 months; the rates did not differ significantly between the treatment groups. The TLR rate for the sirolimus group was 6% and for the bare stent group 13%; the TVR rates were somewhat higher: 13% and 22%, respectively. Mortality rates did not differ significantly between the groups. CONCLUSION: These data demonstrate that the sirolimus-eluting and the bare SMART stent are effective, safe, and free from restenosis in a majority of patients for up to 24 months. Because the restenosis rate in the bare stent group is unexpectedly low, no significant difference could be found between the sirolimus-eluting and the bare SMART stents.

Adult↗
PubMed2005

PTFE-covered self-expanding nitinol stents for the treatment of severe iliac and femoral artery stenoses and occlusions: final results from a prospective study.

PURPOSE: To evaluate the technical performance, safety, and 1-year clinical efficacy of polytetrafluoroethylene (PTFE)-covered nitinol stents in the treatment of atherosclerotic iliac and superficial femoral artery (SFA) disease. METHODS: The multicenter, prospective, nonrandomized COVENT study involved 98 patients (70 men; mean age 64+/-10 years) who received PTFE-covered nitinol stents in 107 arteries (60 iliac and 47 SFAs) after predilation. The average lesion length was 50 mm in the SFA and 45 mm in the iliac arteries. Postdilation was performed when necessary. Duplex ultrasound and ankle-brachial index (ABI) were performed at discharge and at 1, 6, and 12 months in follow-up. RESULTS: In total, 130 stents were placed successfully in 97 (99%) of 98 patients. One stent was misplaced during deployment and required subsequent surgical removal. The average stenosis grade was reduced from 98% to 6% in the SFAs and from 96% to 4% in the iliac arteries after covered stent placement. There was a significant rise of the mean ABI from 0.64 at baseline to 0.97 and 0.95 at 1 and 12 months, respectively (p<0.001). There were 7 primary covered stent occlusions (6.5% of 107 stented lesions: 3 not treated, 2 bypassed, 2 dilated or stented) and 5 (4.7%) recurrent in-stent occlusions (1 bypassed, 2 dilated, 2 untreated) during the 1-year follow-up. Primary patency rates were 92% at 6 months and 89.8% at 12 months for the entire cohort. Secondary patency rates were 98% and 95.6%, respectively. No statistically significant differences were observed in the primary patency rates for the SFAs (89.3% at both 6 and 12 months) versus the iliac arteries (94.3% at 6 months and 90.7% at 12 months). CONCLUSIONS: Primary implantation of PTFE-covered nitinol stents in the iliac and superficial femoral arteries is technically feasible, safe, and effective, with excellent 1-year patency.

Aged↗
PubMed2005

False aneurysm formation following cutting balloon angioplasty in the renal artery of a child.

PURPOSE: To report the fortuitous discovery of a false aneurysm 7 years after cutting balloon angioplasty for severe renal artery fibromuscular dysplasia in a child. CASE REPORT: A 3-year-old girl with neurofibromatosis was referred to our institution because of high blood pressure (220/160 mmHg). Computed tomography identified coarctation of the aorta and severe bilateral renal artery stenoses. The coarctation was successfully resected. One month later, bilateral renal artery angioplasty with a 3-mm balloon was unsatisfactory, so a second angioplasty one month later was done with a 3.25-mm cutting balloon. This procedure was complicated by a minimal arterial rupture, which resolved spontaneously after inflation of a regular balloon. Normal blood pressure was restored. The child was lost to follow-up until 7 years later, when recurrent hypertension (200 mmHg systolic) prompted referral again. Arteriography showed a very severe stenosis on the right side and a 30-mm false aneurysm of the left renal artery at the rupture site. Due to her age, the patient underwent surgery, which brought the blood pressure under control. CONCLUSIONS: False aneurysm of the renal arteries is a rare complication of percutaneous angioplasty. In a child, the cutting balloon would appear to be contraindicated for concentric dysplastic stenoses that are resistant to regular balloon angioplasty.

Aneurysm, False↗
PubMed2004

Changes in renal blood flow reserve after angioplasty of renal artery stenosis in hypertensive patients.

BACKGROUND: Intra-arterial Doppler is a recent technique which allows assessment of distal vascular disease using measurements of intrarenal blood flow velocities. The purpose of this study was to evaluate intrarenal hemodynamics and renal blood flow reserve before and after percutaneous transluminal angioplasty (PTA) in hypertensive patients with unilateral atherosclerotic renal artery stenosis using intra-arterial Doppler. METHODS: Intra-arterial Doppler was performed during arteriography in 19 hypertensive patients (12 men; mean age, 64 +/- 8 years) in "normal" and in "stenotic" kidneys at baseline, on isosorbide dinitrate, and after selective intra-renal papaverine injection, before, and after PTA. Doppler parameters analyzed were average peak velocity, maximum peak velocity, end diastolic velocity, and renal blood flow (RBF). Changes in Doppler parameters after papaverine injection were also analyzed. RESULTS: The major results were (1) the significant reduction in RBF distal to the stenosis, (2) the lack of arteriolar reactivity in response to papaverine distal to the stenosis, (3) the immediate recovery of arteriolar reactivity after PTA, associated with restoration of RBF in the revascularized kidneys, and (4) no change in arteriolar reactivity in response to papaverine in the "normal" kidneys following PTA. CONCLUSION: Ours results highlighted the benefit of endovascular Doppler to evaluate (1) RBF reserve, and (2) the repercussion of the stenosis on the distal vascularization.

Aged↗
PubMed2004

Observations from multidetector CT imaging of different types of renal artery stents.

PURPOSE: To present an optimized protocol for acquisition and reconstruction of multidetector computed tomographic angiographic (CTA) images of the stents most commonly used in renal arteries. TECHNIQUE: CTA was performed on a 16-detector row CT scanner using 0.75-mm collimation. Multiplanar reformatted images perpendicular to the stents and 2-dimensional curved reformatted images were displayed. Two different view windows ("vascular" and "stent") were used, each adapted to the stent density, the vascular wall density, and the aortic enhancement. Five different types of stainless steel balloon-expandable stents were examined; all caused discernable artifacts. These artifacts became more prominent as the stent density increased, becoming most significant when 2 stents were positioned one inside the other. The "stent" window allowed better appreciation of the stent shape and its position compared to the aortic wall and ostial calcifications. The "vascular" window afforded a better view of the vascular lumen, in addition to visualizing the stent in several planes. CONCLUSIONS: Multidetector CTA using dedicated acquisition and reconstruction protocols is capable of visualizing the vascular lumen of different types of renal stents while avoiding metallic artifacts.

Angiography↗
PubMed2003

Limited uterine artery embolization with tris-acryl gelatin microspheres for uterine fibroids.

PURPOSE: To evaluate the midterm results of limited embolization of the uterine arteries in the management of symptomatic uterine fibroids and to evaluate the efficacy and safety of limited uterine artery embolization (UAE) with use of calibrated tris-acryl gelatin microspheres in the management of symptomatic uterine fibroids. MATERIALS AND METHODS: Twenty women (mean age, 43 years) with symptomatic uterine fibroids underwent bilateral embolization of the uterine arteries with use of calibrated microspheres. Devascularization of the fibroids was achieved and the main uterine artery was left patent in all women. Embolization was offered as an alternative to surgery in all women who had been treated unsuccessfully with medical therapy. RESULTS: All procedures were technically successful. Microspheres 700-900 micro m in diameter were used in 14 women (70%). After a mean follow-up duration of 30.2 months (range, 24-48 mo), all women reported improvement in their symptoms, with 85% reporting complete resolution of menorrhagia at the most recent follow-up. One woman with multiple fibroids required a second embolization procedure because of persisting symptoms at 6 months. She is currently symptom-free after 48 months. In two women with submucosal fibroids, expulsion of necrotic fibroids occurred 2 and 7 months after the procedure, respectively. All women resumed normal menstruation after the procedure. One woman had a successful full-term pregnancy after embolization. CONCLUSION: Early experience with UAE with use of calibrated tris-acryl gelatin microspheres indicates that it is safe and efficacious in controlling menorrhagia.

Adult↗
PubMed2003

Multicenter trial of the Jostent balloon-expandable stent-graft in renal and iliac artery lesions.

PURPOSE: To report the results of a multicenter feasibility study of the Jostent balloon-expandable stent-graft in the treatment of renal and iliac artery lesions. METHODS: Twenty-three patients (17 men; mean age 62 years, range 38-80) with lesions in the renal (n=12) or iliac arteries (n=12) were enrolled in 6 centers over a 1-year period. Preprocedural computed tomography (CT) and angiography were performed in all patients. The Jostent device was implanted in the 24 arteries to treat 11 in-stent stenoses, 2 arterial ruptures, 2 aneurysms, 2 dissections, 2 ulcerated stenoses, and 5 chronic occlusions. Follow-up included color duplex ultrasound examination on the day after the procedure and at 6 months; patients with renal artery stent-grafts were also evaluated with CT angiography. RESULTS: Twenty-seven stent-grafts were deployed successfully in the 24 (100%) arteries. Seven (30%) patients required adjunctive procedures to address 1 acute in-stent thrombosis, 2 dissections, and 4 in-stent residual stenoses. At 6-month follow-up, 2 (8.3%) restenoses occurred in the renal arteries; these were treated successfully using balloon angioplasty. CONCLUSIONS: These data suggest that a balloon-expandable stent-graft may be safe and useful in patients with selected peripheral indications.

Adult↗
PubMed2003

Endovascular treatment of acute complications associated with aortic dissection: midterm results from a multicenter study.

PURPOSE: To evaluate endovascular procedures in the management of acute ischemic complications and rupture of the false lumen in aortic dissections. METHODS: Data on patients with aortic dissection and noncardiac acute complications (peripheral ischemia or thoracic aortic rupture) treated with endovascular techniques were collected from 10 institutions and retrospectively analyzed. From March 1997 to January 2000, 58 patients (50 men; mean age 59.6+/-12.8 years) were treated for 19 (33%) type A and 39 (67%) type B dissections. Twelve (21%) patients had thoracic aortic rupture; 46 (79%) patients had one or more peripheral ischemic complications that included bowel pain (19, 41%), anuria associated with acute renal insufficiency (18, 39%), lower limb ischemia (15, 33%), and/or uncontrolled hypertension with renal ischemia (14, 30%). RESULTS: In the thoracic rupture cohort, all 12 patients were treated successfully with stent-grafts; one distal endoleak required a secondary procedure. There were 2 (12%) periprocedural deaths; one patient developed transient paraplegia after a secondary surgical procedure. In the 46 patients treated with stent implantation, fenestration, or both for peripheral ischemic symptoms, 44 (96%) had patency restored to the malperfused vessel. Eight (17%) patients died within 30 days. Over a mean follow-up of 8.2+/-8.9 months, the false lumen had thrombosed in 7 (70%) of the stent-graft patients. In the 38 surviving ischemic patients, the diameters of the true and false lumens and maximum transverse aorta all increased; only 4 (11%) had total thrombosis of the false lumen. CONCLUSIONS: Endovascular treatment of noncardiac acute complications associated with aortic dissection has favorable early and midterm outcomes.

Acute Disease↗
PubMed2003

Relationship of intimal flap position to endovascular treatment of malperfusion syndromes in aortic dissection.

PURPOSE: To propose a classification system based on the position and extension of the intimal flap to assist in the endovascular repair of aortic dissection complicated by a malperfusion syndrome. METHODS: Forty-one patients (34 men; mean age 58 years, range 22-78) with 19 type A and 22 type B dissections complicated by a malperfusion syndrome were treated with stenting, fenestration, or both for the peripheral ischemia. A retrospective review of the preprocedural imaging studies (computed tomographic angiography and arteriography) was performed to determine and categorize the position of the aortic intimal flap. In type 1, the flap was either parallel to or perpendicular to the origin of the malperfused collateral artery; type 2 referred to extension of the dissection into the collateral vessel, while type 3 represented the presence or absence of an avulsed branch ostium. RESULTS: Patients treated with stenting (n=19) alone had type 2 or type 3 arterial dissections, whereas the 12 patients who were treated with fenestration alone had type 1 lesions. Ten patients treated with stenting and fenestration had arterial lesions in which a type 1 dissection was associated with types 2 or 3. CONCLUSIONS: This appearance-based imaging approach combined with the symptoms of malperfusion syndromes during aortic dissection can help guide the endovascular treatment strategy.

Adult↗
PubMed2002

Coarctation of the aorta: comparison of aortic dimensions between conventional MR imaging, 3D MR angiography, and conventional angiography.

Magnetic resonance angiography is increasingly used as a non-invasive method in the evaluation of coarctation of the aorta. The aim of this study was to compare aortic dimensions calculated by MR angiography and those obtained by more conventional MR sequences and conventional angiography. Twenty-six consecutive patients with coarctation underwent three-dimensional MR angiography. Two independent observers retrospectively evaluated three aortic segments, site of coarctation, presence of aneurysm and existence of collateral circulation. Three aortic segments were also compared with those obtained on classical MR sequences and conventional angiography. The MR angiography was successfully performed in all showing 1 aneurysm and collateral circulation in 8 patients. Almost perfect intraobserver ( r(2)>0.91) and excellent interobserver ( r(2)>0.80) reliabilities were obtained for each aortic segment no matter which MR sequence was employed. Similarly, mainly excellent ( r(2)>0.80) concordance analysis was observed between MR angiography measurements and those calculated by either spin-echo/gradient-echo sequences or conventional angiography. This study demonstrates that MR angiography is a fast, accurate and reproducible method in the evaluation of coarctation of the aorta. It provides excellent anatomic information and reliably detects collateral vessels. Magnetic resonance angiography could probably replace the conventional angiography and will provide an additional diagnostic value in combination with turbo spin-echo sequence.

Adolescent↗
PubMed2002

Cortical thickness: an early morphological marker of atherosclerotic renal disease.

BACKGROUND: Although kidney size is still the most commonly used morphological parameter, it is not sensitive enough for early detection of atherosclerotic renal disease (ARD). The purpose of this work was to evaluate morphological abnormalities on both post-stenotic and contralateral kidneys, by using spiral computed tomography angiography (CTA). METHODS: Spiral CTA was performed in 49 hypertensive patients. Renal diameters, renal length, and cortical thickness were measured in 26 post-stenotic kidneys, 26 contralateral kidneys and 46 control kidneys. Mean cortical thickness, cortical area, and medullary length were calculated. RESULTS: The right and left control kidneys were of comparable morphology. The post-stenotic kidneys showed significant cortical atrophy. The contralateral kidneys also underwent cortical disease, as judged by comparison with control kidneys. A threshold of 800 mm2 was identified for the cortical area that allowed us to distinguish control kidneys from post-stenotic kidneys. Similarly, a threshold of 8 mm was identified for mean cortical thickness. Renal length was still within normal range in all kidney groups. The measurement of superior pole segments appeared to be more sensitive than measurement at other locations for identifying significant intrarenal lesions. There was no significant correlation between clinical and morphological parameters. CONCLUSIONS: These results suggest that cortical parameters are more sensitive for early diagnosis of ARD than kidney size. Cortical atrophy should be a useful marker for guidance for revascularization.

Adult↗
PubMed2002

Parenchymal consequences of fibromuscular dysplasia renal artery stenosis.

PURPOSE: The aim of this study is to assess parenchymal consequences of fibromuscular dysplasia (FMD) renal artery stenosis (RAS) in hypertensive patients by spiral computed tomographic angiography (CTA). METHODS: Spiral CTA was performed in 20 essential hypertensive (EH) patients (40 EH kidneys and 20 hypertensive patients with unilateral FMD stenosis (20 poststenotic [S] kidneys, 20 opposite [OPP] kidneys). Renal length (RL; in millimeters), mean cortical thickness (MCT; in millimeters), cortical area (CA; in square millimeters), and medullary length (ML; in millimeters) were evaluated. RESULTS: Blood pressure, creatinine clearance, and long-standing hypertension were similar in both groups of patients. Compared with EH kidneys, S and OPP kidneys showed significant cortical thinning (MCT(EH) = 9.2 +/- 0.8 mm versus MCT(OPP) = 7.8 +/- 1.0 mm versus MCT(S) = 7.3 +/- 1.0 mm; P < 0.0001). RL and ML were reduced only in the S kidney group, with RL(EH) = 103 +/- 11 mm versus RL(OPP) = 105 +/-10 mm versus RL(S) = 96 +/- 11 mm; P = 0.05; and ML(EH) = 84 +/- 11 mm versus ML(OPP) = 89 +/- 9 mm versus ML(S) = 81 +/- 10 mm; P = 0.05, respectively. CA and MCT correlated significantly with creatinine clearance in the entire population (r = 0.43; P = 0.005; r = 0.35; P = 0.02, respectively). CONCLUSION: Unilateral RAS was associated with bilateral cortical thinning in FMD disease. Cortical atrophy appears to be an accurate marker of unilateral RAS. Its use as a potential screening method for RAS should be investigated further.

Age Factors↗