Fluorescein interference with homocysteine testing.
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Biomedical subjects
Jeffrey L Marx
Publications and source records attributed to Jeffrey L Marx.
Symptoms of musculoskeletal disorders in ophthalmologists.
OBJECTIVE: To describe the presence of musculoskeletal disorders (MSDs) of the neck, low back, and upper extremity among ophthalmologists. DESIGN: Survey. METHODS: Mail survey using a pretested instrument to 2,529 ophthalmologists in the Northeastern United States; 697 ophthalmologists (28%) returned a completed survey. RESULTS: Self-reported prevalence of neck, upper body, or lower back symptoms in the prior month was 51.8%. Low back pain was present in 39% of respondents, followed by upper extremity symptoms (32.9%) and neck pain (32.6%). Approximately 15% of ophthalmologists were slightly to moderately limited in their work as a result of these symptoms. CONCLUSION: MSD symptoms appear to be common among ophthalmologists. With a relatively low response rate, however, it is plausible that asymptomatic subjects represent a large percentage of the nonrespondents. Additional investigation is warranted to evaluate ergonomic risk factor exposure and establish injury prevention guidelines.
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Percutaneous carotid artery angioplasty and stenting for ocular ischemic syndrome.
PURPOSE: To describe percutaneous carotid angioplasty and stenting to treat ocular ischemic syndrome resulting from severe intracranial carotid artery stenosis. DESIGN: Retrospective case series of 3 patients with ocular ischemic syndrome and intracranial carotid artery stenosis. INTERVENTION: All patients underwent carotid artery evaluation, including ultrasound, transcranial Doppler, magnetic resonance imaging or magnetic resonance angiography,and angiography. Carotid angioplasty and stenting was performed in all patients. MAIN OUTCOME MEASURES: Carotid angiography, fluorescein angiography, and transcranial Doppler imaging were used to evaluate cerebral and ocular perfusion. RESULTS: Cerebral perfusion improved in all patients. Fluorescein angiography arteriovenous transit times improved in 2 patients. One patient had a correction in the reversal of flow through the ophthalmic artery. Visual acuity remained stable or improved in all patients. There were no complications associated with the procedure. CONCLUSIONS: Intracranial carotid artery stenosis is a rare cause of ocular ischemic syndrome. With the advent of carotid angioplasty and stenting, stenotic lesions previously not amenable to carotid endarterectomy are now treatable with stenting. A complete work-up of the carotid artery is necessary in all cases of ocular ischemic syndrome to ensure evaluation of the entire carotid artery system. Early diagnosis of intracranial carotid stenosis is important for preservation of visual function and reducing risk of cerebral vascular event.
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Homocysteine: a risk factor for retinal venous occlusive disease.
PURPOSE: Recent studies have shown a relationship between elevated levels of homocysteine and vascular disease including cerebrovascular accidents and myocardial infarctions. We evaluated patients with a recent retinal vein occlusion to determine if there was an associated elevation of homocysteine. DESIGN: Age and gender matched case-controlled study. PARTICIPANTS: Twenty patients with retinal venous occlusive disease within the previous 6-month period and 40 control patients without retinal venous occlusive disease were enrolled in the study. METHODS: Twenty patients with a history of retinal vein occlusion underwent laboratory testing to determine serum homocysteine levels. In addition, a health survey was completed and several laboratory tests relating to vascular disease including cholesterol were checked. Two control groups were selected. The first group included patients with diabetes and no history of retinal vascular occlusive disease. The second control group included nondiabetic patients who also had no prior history of retinal vascular occlusive disease. MAIN OUTCOME MEASURES: The main parameter measured in this study is fasting homocysteine. RESULTS: Fifteen of 20 patients (75%) with retinal vein occlusion disease had an elevated fasting serum homocysteine level, whereas only 5 of 40 control patients (13%) had an abnormal homocysteine level (P < 0.0005). CONCLUSIONS: Patients with retinal venous occlusive disease have higher levels of homocysteine, which may serve as a modifiable risk factor.
Adult↗
Early treatment of cystoid macular edema secondary to branch retinal vein occlusion with intravitreal triamcinolone acetonide.
BACKGROUND AND OBJECTIVE: To determine the efficacy of intravitreal triamcinolone acetonide (IVTA) in the early treatment of severe cystoid macular edema (CME) related to acute branch retinal vein occlusion. PATIENTS AND METHODS: Retrospective, non-comparative case series. Twelve eyes with severe CME (foveal thickness > 450 microm) secondary to acute branch retinal vein occlusion received IVTA. RESULTS: Average follow-up was 15.3 months. Mean visual acuity was 0.88 LogMar units (20/160) initially, 0.55 LogMar units (20/70) at 1 week, 0.46 LogMar units (20/60) at 1 month, and 0.49 LogMar units (20/60) at last follow-up. Visual acuity improved by 3 lines or greater in 42% of patients at 1 week, 50% at 1 month, and 42% at last follow-up. Average foveal thickness was 589 microm (range, 460 to 840 microm) at baseline, 237 microm at 1 week, 196 microm at 1 month, and 235 microm at last follow-up. All eyes showed reduction of foveal thickness as measured by optical coherence tomography. Eight eyes developed recurrent CME at an average of 5.5 months after initial IVTA injection. Ten eyes required additional intervention during the follow-up period. CONCLUSIONS: Early treatment of severe CME secondary to branch retinal vein occlusion with IVTA is effective in reducing foveal thickness as measured by optical coherence tomography and improving visual acuity. However, monotherapy with IVTA can be associated with a significant rate of recurrent CME.
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