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Biomedical subjects

Jehn-Shyun Huang

Publications and source records attributed to Jehn-Shyun Huang.

8 recordsLinked to original sources

The outcome expectancy model for areca-quid chewing behavior.

Outcome expectancies as regards areca-quid chewing played an important role in areca-quid addiction. In this study, areca-quid user expectancies will be explored. A total of 179 adolescents selected from high school completed the areca-quid chewing expectancy questionnaire and related chewing-behavior scale. Three factors (physical/emotional reward, negative consequences and social benefit) relating to areca-quid chewing behavior were explored by factor analysis and the two-dimensional model of chewing expectancy (positive-negative effect of chewing and physical-social reaction to chewing) was found using non-metric multi-dimensional scaling. The structure of the areca-quid chewing expectancy was determined for an adolescent group and the social factors involved in areca-quid chewing clearly warrant further investigation.

Adolescent↗

Extensive maxillary sequestration resulting from mucormycosis.

Mucormycosis is an invasive and potentially lethal infection caused primarily by fungi of the order mucorales. An ulcer or extraction in the mouth can be the port of fungal invasion, particularly when the patient is immunocompromised. Early recognition and aggressive treatment have reduced the mortality and morbidity. We present a case of oral mucormycosis with extensive maxillary osteonecrosis that is of interest because the patient ignored the initial warning signs and was rescued from the fulminating stage by thorough debridement and medical treatment.

Follow-Up Studies↗

Comparison of 2 methods of making surgical models for correction of facial asymmetry.

PURPOSE: Stereolithography is useful in reconstructive surgery in that the surgical template or customized implant can be prefabricated on the models. To correct facial asymmetry, prior reshaping of the replica of the original structures is frequently required before it can be used as a surgical model. This is traditionally accomplished by direct sculpturing. This method has its limitations in clinical use. Recently, we developed a method using computer techniques to reconstruct the required structures. We herein report several of its applications in a variety of clinical situations and compare this virtual method with the traditional method. PATIENTS AND METHODS: With the traditional method, reconstruction of the models was handmade on the replica of the original structures. In the virtual method, the anticipated reconstructions were completed on the computer using various image-processing tools and were verified by the surgeons before sending to stereolithography. Thirteen patients who had undergone surgical correction of facial asymmetry using models made by either method were retrospectively reviewed. The traditional method was used in 5 of them while the virtual method was applied in the other 8 patients. The surgical models and the patients following the reconstruction were evaluated for symmetry and esthetics. RESULTS: To construct implants or to precontour fixation plates, an average of 1.4 models was fabricated for each patient using the traditional method, whereas only 1.1 models were made for each patient in the virtual method group. Both methods worked satisfactorily in restoring symmetry of the bony structures on the models. However, the projection of the chin on the model created by the traditional method was inadequate, as showed postoperatively in 1 patient. There was surface roughness on the customized area of the models made by the virtual method. The surgical result was poor in symmetry in 1 case in the traditional method group. One patient in the virtual method group showed irregularities on the temporal region following augmentation with prefabricated bone cement implant. CONCLUSIONS: Both methods of making models were useful and effective in surgical reconstruction for facial symmetry in selected cases. The virtual method was preferred in cases where midline structures had already been deformed, or when soft tissue was involved in reconstruction. From the technical standpoint, the virtual method was superior because of its versatility, predictability, precision, communicability, and the convenience of storage and documentation.

Adolescent↗

Effects of splinted prosthesis supported a wide implant or two implants: a three-dimensional finite element analysis.

OBJECTIVES: Three-dimensional finite element (FE) models of splinted prosthetic crowns were studied and stress analyses were evaluated with different types of implant support, including standard, wide or two implant(s) for partial, posterior edentulous restorations. MATERIAL AND METHODS: The FE models were constructed based on a cadaver mandible containing the 2nd premolar and the 1st molar. The crowns of these two teeth were modeled as connected and disconnected to mimic the splinted and non-splinted designs, respectively. One standard implant was placed at the premolar region, while three types of implant support, one at a time (the standard implant, wide implant and two implants), were used to support the molar crown. A 100 N oblique load was applied to the buccal cusp on each crown. The FE simulation was validated experimentally via strain gauge measurement. RESULTS: The experimental data were well correlated with the FE predictions (r(2)=0.97). When compared with the standard implant used in the molar area, the wide implant and two implants reduced the peak stress in crestal bone by 29-37% for both splinted and non-splinted cases. Inserting the standard implant into both the premolar and molar area, the bone stresses were identical for splinted and non-splinted designs. However, splinting the adjacent crowns has shown to decrease the bone stresses at the premolar region by 25%, while the wide implant or two implants were placed at the molar region. CONCLUSION: The biomechanical advantages of using the wide implant or two implants are almost identical. The benefit of load sharing by the splinted crowns is notable only when the implants on the premolar and molar regions have different supporting ability.

Alveolar Process↗

The inverted temporalis muscle flap for intraoral reconstruction: its rationale and the results of its application.

PURPOSE: The purpose of this article was to show the discrepancies among the different parts of the temporalis muscle flap (TMF), to introduce a new rotational arc for the TMF based on these findings, and to examine the outcomes associated with the use of this modified method. MATERIALS AND METHODS: Two models were established on 5 human skulls to mimic the situations with the usual dissection technique or the extended dissection technique for the TMF. The lengths of the anterior part, the middle part, and the posterior part of the flap were measured and analyzed for statistical significance. A new rotational arc for the TMF was introduced, in which the flap was inverted beneath the zygomatic arch, placing the temporalis fascia away from the oral side. Seventeen consecutive oral cancer cases treated with either the traditional method or the inverted method of flap transposition were reviewed and divided into 2 groups dictated by the rotational arcs of their flaps. The traditional TMF was used in 11 cases and the inverted TMF was used in 6 cases. Clinical examination and imaging studies were used for assessment of outcome, and the results from the 2 patient groups were compared. RESULTS: The middle and posterior parts of the temporalis muscle were significantly longer than the anterior part on the skull models. However, the middle and posterior parts did not differ greatly in length. The extended dissection technique increased the flap length except for the anterior part. Both flaps were successful in closing the defects in all cases and healed well. No muscle necrosis was observed. However, the patients receiving the traditional TMF developed noticeable cheek fullness in 4 instances, sialocele in 3, significant reduction of range of mouth opening in 2, and distinct velopharyngeal insufficiency in 2, whereas only 1 case in which the inverted TMF was used developed cheek fullness. CONCLUSIONS: The middle or posterior part of the temporalis flap is preferred over the anterior part for covering distant defects because of its extra length. The inverted TMF is simple and safe to apply. It can extend farther in the posterior oral cavity and has fewer complications than the traditional TMF.

Adult↗

Areca quid chewing by Taiwanese adolescents: application of the Attitudes Social Influence Self-efficacy (ASE) model.

AIMS: To investigate the factors associated with areca quid-chewing behaviour using the Attitudes-Social influence-Self-efficacy (ASE) model as a theoretical framework. DESIGN: Cross-sectional survey. SETTING AND PARTICIPANTS: A total of 400 students from a junior high school participated in the study in 2001 in Chia-Yi city (Taiwan). MEASUREMENTS: Expectancy scales (for the attitude component of the ASE), a self-efficacy scale (for the self-efficacy component of the ASE) and a social norm scale (for the social influence component of the ASE) were utilized. These measures displayed good reliability and validity. FINDINGS: Forty-seven students (11.75%) reported that they had tried chewing areca quid previously, eight of them practicing chewing it every day. Positive and negative expectancy (r = 0.43, r=- 0.20), self- efficacy (r = - 0.65), and subject social norm (r = 0.53) were significantly correlated with participants' intentions to chew areca quid. In a regression model, self-efficacy (beta = - 0.46, P < 0.001), social norm (beta = 0.22, P < 0.001), positive expectancy (beta = 0.18, P < 0.001) and negative expectancy (beta = - 0.08, P = 0.040) all made independent contributions to predicting intentions to chew and explained 46.8% of the variance in areca quid-chewing behaviour. CONCLUSIONS: Areca quid chewing appeared to be linked to positive expectancy and social norms pertaining to areca quid chewing associated with adolescents. However, high negative expectancy and high self-efficacy encouraged contrary behaviour. The application of the ASE model as the scenario could improve our understanding of the intention of the areca quid chewing among these adolescents.

Adolescent↗

Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan.

BACKGROUND: Alterations in p21WAF1 protein expression have been observed in a wide variety of human cancers by immunohistochemistry, and both decreased and increased levels of p21WAF1 protein expression have been shown to correlate with poor prognosis. METHOD: To examine the relation between p21WAF1 protein expression and prognosis in oral squamous cell carcinomas (SCCs), we performed an immunohistochemical study with antip21WAF1 antibody on 43 oral SCCs. Immunostaining results were then correlated with p53 protein levels, clinicopathological parameters of the tumors and overall patient survival. RESULTS: Of the 43 patients, 31 (72%) had tumors with positive p21WAF1 nuclear staining and 27 (63%) had tumors with p53 nuclear staining. There was no significant correlation between p21WAF1 and p53 protein expressions and both mutant p53-containing oral SCCs overexpressed p21WAF1 protein. In addition, no significant correlation was found between the p21WAF1 expression and the patients' age, sex, oral habit, cancer location, or primary tumor TNM status at the time of initial presentation. The Kaplan-Meier analysis showed a significant correlation between p21WAF1 protein overexpression and poor patient overall survival (P = 0.049). When p53 and p21WAF1 were evaluated together, the 5-year overall survival was lowest in p53(+)-p21WAF1(+) patients and highest in p53(-)-p21WAF1(-) patients (P = 0.057). CONCLUSION: Combined evaluation of p21WAF1 and p53 expressions may be useful in estimating the prognosis of patients with oral SCCs in Taiwan.

Adult↗