PubMed Health⌕ Search

Biomedical subjects

Jennifer Anderson

Publications and source records attributed to Jennifer Anderson.

32 records · Page 2Linked to original sources
PubMed2003

Use of the stages of change model in improving nutrition and exercise habits in enlisted Air Force men.

Thirty-nine U.S. Air Force enlisted men participated in a randomized controlled study that evaluated an experimental program designed to enhance fitness. Subjects were assigned to either a treatment (access to the program) or control (no access to program) group for 6 months. To improve treatment group fitness (as measured by VO2, subjects received individually tailored information (based on a behavior change model) via the Internet to encourage adoption of positive diet and exercise behaviors. Results showed no significant effect in improving fitness in treatment. However, significant effects were observed for secondary outcomes such as weight (controls, +1.0 kg vs. treatment, -2.2 kg, p < 0.05), body mass index (+0.3 kg/m2 vs. -0.7 kg/m2, p < 0.05), and percent body fat (+0.6% vs. -1.5%, p < 0.001). The data suggest that the individually tailored exercise information was not effective in encouraging sufficient exercise intensity to impact fitness. However, the dietary tailored information appears to have encouraged the adoption of more positive nutritional practices as demonstrated by the beneficial effects reflected in secondary outcomes.

Adult↗
PubMed2002

Use of laboratory tests and clinical symptoms for identification of primary HIV infection.

OBJECTIVE: To determine the sensitivity and specificity of symptoms, three HIV-1 RNA assays, a p24 antigen EIA and a third-generation enzyme immunoassay (EIA) antibody test for diagnosis of primary HIV infection (PHI). DESIGN: Prospective cohort in a university research program. PARTICIPANTS: Of 258 eligible persons screened for PHI, 40 had primary/early infection (22 preseroconversion, 18 within 6 months of seroconversion) and 218 did not. Seven participants with preseroconversion HIV-1 from a second center were added for evaluating laboratory tests. MAIN OUTCOME MEASURE: PHI, defined as a negative or indeterminate antibody test with subsequent conversion. Symptom analysis also included persons with antibody conversion of less than 6 months' duration. RESULTS: The symptoms most strongly associated with PHI in multivariate analysis were fever [odds ratio (OR) 5.2; 95% confidence interval (CI) 2.3-11.7] and rash (OR 4.8; 95% CI 2.4-9.8). The sensitivity and specificity, respectively, for detecting preseroconversion HIV infection were: p24 antigen, 79% and 99%; third-generation EIA, 79% and 97%; HIV-1 RNA by branched chain DNA 100% and 95%; HIV-1 RNA by polymerase chain reaction 100% and 97%; HIV-1 RNA by transcription-mediated amplification testing, 100% and 98%. False-positive HIV-1 RNA tests were not reproducible and had values < 3000 copies/ml, while only one person with confirmed PHI was in this range. CONCLUSIONS: Rash and fever indicated the highest risk of PHI. HIV-1 RNA tests are very sensitive for PHI but false-positive results occur. False-positive results can be reduced through duplicate testing and considering tests < 5000 copies/ml as indeterminate results requiring additional testing. p24 antigen was more specific than HIV-1 RNA testing but less sensitive.

Adult↗
PubMed2002

Adjustment in children with intractable epilepsy: importance of seizure duration and family factors.

Seventy-five families of children with intractable epilepsy but without a severe learning disability (mean age 7 years 1 month, SD 2 years 6 months; range 2 to 12 years) who attended a regional paediatric neurology service, were surveyed. A postal questionnaire was used which included standardized measures of child and family adjustment; forty-eight families responded (64%; 31 males, 17 females). There was no significant difference between responders and non-responders in terms of age, sex, number of other chronic illnesses and disabilities, age at epilepsy diagnosis, seizure type, nor number of antiepileptic drugs currently prescribed (p > 0.05). The importance of including multidimensional measures of outcome was highlighted by the finding that epilepsy, pharmacological, and psychosocial factors were differentially associated with specific adjustment difficulties. Two factors appeared to be most pervasively implicated across a range of adjustment problems: frequency of rectal diazepam administration and family patterns of relating to each other (p < 0.05). It appeared that duration of seizures (as indicated by frequency of rectal diazepam administration), rather than the frequency of seizures per se, was more pernicious in terms of poor adjustment. Intrafamilial relations (degree of conflict/cohesion and soon) were not only associated with adjustment difficulties in the child, but also with the frequency of seizures themselves. Implications for psychological interventions in intractable epilepsy in childhood are highlighted.

Adaptation, Psychological↗
PubMed2001

Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.

The sordarin class of natural products selectively inhibits fungal protein synthesis by impairing the function of eukaryotic elongation factor 2 (eEF2). Mutations in Saccharomyces cerevisiae eEF2 or the ribosomal stalk protein rpP0 can confer resistance to sordarin, although eEF2 is the major determinant of sordarin specificity. It has been shown previously that sordarin specifically binds S. cerevisiae eEF2 while there is no detectable binding to eEF2 from plants or mammals, despite the high level of amino acid sequence conservation among these proteins. In both whole-cell assays and in vitro translation assays, the efficacy of sordarin varies among different species of pathogenic fungi. To investigate the basis of sordarin's fungal selectivity, eEF2 has been cloned and characterized from several sordarin-sensitive and -insensitive fungal species. Results from in vivo expression of Candida species eEF2s in S. cerevisiae and in vitro translation and growth inhibition assays using hybrid S. cerevisiae eEF2 proteins demonstrate that three amino acid residues within eEF2 account for the selectivity of this class of compounds. It is also shown that the corresponding residues at these positions in human eEF2 are sufficient to confer sordarin insensitivity to S. cerevisiae identical to that observed with mammalian eEF2.

Amino Acid Sequence↗
PubMedDate not supplied

Using computer-based assessments to evaluate interactive multimedia nutrition education among low-income predominantly Hispanic participants.

OBJECTIVE: This research was conducted to measure the effectiveness of interactive multimedia (IMM) with low-income Hispanic persons. DESIGN: The effectiveness of the program was examined using a quasi-experimental pretest/post-test control group design. SETTING: Subjects were recruited from nutrition, health, and English as a Second Language (ESL) programs in Colorado. PARTICIPANTS: Thirty-six intervention and 34 control participants formed a convenience sample of low-income and predominantly Hispanic persons. INTERVENTION: Intervention participants received a 15-minute module about breakfast. Control participants received a non- nutrition-related IMM module. MAIN OUTCOME MEASURES: Primary variables included knowledge, attitude, and stage of change scores. ANALYSIS: Paired and independent sample t tests, chi-square analysis, and repeated-measures analysis of covariance (ANCOVA) were used. RESULTS: Intervention participants significantly increased knowledge, attitude, and total scores (P <.001) between pretest and post-test and had significantly greater increases than the control group (P <.001). CONCLUSIONS: The results support using IMM to disseminate nutrition education to the target population and the feasibility of using computer-based questionnaires to evaluate the effectiveness of IMM nutrition education programs. IMPLICATIONS: This research provides the basis for the continued development of computer-based assessment tools.

Adult↗
PubMedDate not supplied

Economic analysis of bilingual interactive multimedia nutrition education.

CONTEXT: Interactive multimedia (IMM) provides a means to deliver accurate, consistent, and convenient nutrition education. OBJECTIVE: To compare direct costs of bilingual IMM and peer nutrition education methods. DESIGN: Cost per unit of nutrition education for each delivery method was calculated. SETTING: Touch-screen computer kiosk systems in food assistance programs. PARTICIPANTS: Approximately 727 low-income and Hispanic persons. INTERVENTION: Bilingual IMM and nutrition education classes taught by peer educators. MAIN OUTCOME MEASURES: Cost per unit of nutrition education delivered. ANALYSIS: Descriptive: to compare costs and determine break-even points. RESULTS: Initially, costs for both methods dropped and then nearly leveled for the peer method at a break-even point of 633 units, whereas those for IMM continued to decrease. CONCLUSIONS: Interactive multimedia is a cost-effective method of delivering nutrition education, especially to large numbers of people. IMPLICATIONS: Use of this technology could reach additional low-income persons at decreasing costs.

Computer-Assisted Instruction↗
PubMedDate not supplied

Validation of a tool to measure processes of change for fruit and vegetable consumption among male college students.

OBJECTIVE: To develop a valid tool to measure processes of change for fruit and vegetable consumption, and examine the relationship between stage and processes of change among several cultural groups. DESIGN: Cross-sectional, using a self-report questionnaire. SETTING: Convenience sample of male college students living in apartments. PARTICIPANTS: 105 US white, 53 international Latino, and 92 international Asian males. MAIN OUTCOME MEASURES: Fruit and vegetable intake, stage and processes of change characterizations. ANALYSIS: Analysis of covariance, with age as a covariate, was used to determine differences in processes of change scores among 3 cultural groups and stages of change. Two-way analysis of variance investigated relationships between stage of change and fruit and vegetable consumption. The pattern of differences across cultural groups was examined using chi-squared analysis. RESULTS: Self-reported fruit and vegetable intake was higher (P < .01) in action and maintenance than in other stages. Participants in precontemplation/contemplation used significantly less of any process of change than those in preparation or action/maintenance. There were no significant interactions between stage of change and culture for any of the processes of change, but international Asians used significantly more dramatic relief and environmental reevaluation than did US whites and more stimulus control processes than US whites or international Latinos. At all stages, students used significantly more cognitive/experiential processes than behavioral processes. CONCLUSIONS AND IMPLICATIONS: The use of processes increased within action-oriented stages, consistent with previous studies using the Transtheoretical Model in the nutritional area. The greater use of cognitive/experiential than behavioral processes at all stages was not consistent with predictions. Evidence of cultural differences in the use of processes of change was found.

Adolescent↗
PubMedDate not supplied

Using social marketing principles to guide the development of a nutrition education initiative for preschool-aged children.

Within the field of nutrition education, social marketing has become a promising framework to systematically approach problems related to nutrition behavior. In 1997, the Colorado Nutrition Network began developing a social marketing campaign to promote healthful food choices among low-income Coloradans. A multifaceted formative evaluation plan that included focus groups, campaign concept pretesting, and a food frequency questionnaire was used to segment and scrutinize the target audience. The resulting pilot program was a blend of educational and marketing strategies targeting preschoolers that was implemented in Head Start classrooms. The 12-week intervention contained a narrow, behavior-based "try new foods" message, multiple nutrition education activities, and repeated opportunities to taste 13 novel foods. Key strategies used and findings from the formative evaluation process are presented herein in an effort to provide insight for nutrition educators interested in developing similar interventions.

Child↗
PubMedDate not supplied

Assaultive behavior intervention in the Veterans Administration: psychodynamic group psychotherapy compared to cognitive behavior therapy.

PURPOSE: To compare the efficacy of a psychodynamic psychotherapy group (PPG) and a cognitive-behavior group (CBG) for male veterans with a history of assault. METHODS: Data collected included the Addiction Severity Index, the Overt Aggression Scale, and the State-Trait Anger Expression Inventory. Subjects (N = 27) were assigned randomly to a central group, PPG, or CBG. Analyses included an overall comparison of the groups as well as repeated-measures analyses and adjustments for covariates. FINDINGS: The PPG showed a trend toward improvement of overt aggression and significant improvement of trait aggression compared with CBG. There were no differences in state aggression or efforts to control aggression. CONCLUSIONS: Both the PPG and CBG are effective treatments for aggression.

Cognitive Behavioral Therapy↗
PubMedDate not supplied

Follicular carcinoma of the thyroid with aggressive metastatic behavior in a pregnant woman: report of a case and review of the literature.

Distant metastases as initial presentation of follicular carcinoma of the thyroid is rare, especially in young patients. We report the clinical and pathological features of a 33-year old pregnant patient with follicular carcinoma of the thyroid who presented with widespread bone and lung metastases at the time of diagnosis. the resected tumor had a focal insular component that showed extensive vascular invasion spreading beyond the thyroid capsule, and was associated with widespread bone and lung metastases. Despite its aggressive behavior, the tumor had low mitotic activity and Ki-67 nuclear labeling index. tumor cells showed high microvascular density and down-regulation of E-cadherin, a calcium-dependent trans-membrane epithelial protein molecule known to promote intercellular adhesion. We suggest that architectural differentiation of the tumor and cell proliferation rate are not reliable markers of metastatic behavior in this particular thyroid neoplasm. Microvascular density and down-regulation of E-cadherin expression in the tumor should be included among histologic hallmarks of metastatic potential. the role of pregnancy in the aggressive behavior of this tumor is discussed along with a literature review.

Adenocarcinoma, Follicular↗
PubMedDate not supplied

Using self-efficacy and a transtheoretical model to develop a physical activity intervention for obese women.

PURPOSE: To assess the effectiveness of applying behavior change theory to a physical activity intervention for obese, sedentary women. DESIGN: A 48-week randomized controlled trial. Subjects were randomized to one of two intervention groups. SETTING: A university classroom and a local health club. SUBJECTS: Fifty-eight sedentary, obese women. INTERVENTIONS: A 24-week theory-based physical activity program that aims to change the way subjects think and behave in relation to physical activity (treatment group, n = 29) and a traditionally structured exercise program (control group, n = 29). MEASURES: Questionnaires on physical activity, stage of change, processes of change, and self-efficacy were completed at baseline, 24 weeks, and 48 weeks. RESULTS: Twenty-seven of the 29 participants in the treatment group and 17 participants in the control group completed the study. Analysis of variance revealed significant and positive changes in measures of eight processes of change, self-efficacy, physical activity, and cardiorespiratory fitness in the treatment group at 24 weeks. All but one of these changes were maintained at 48 weeks. In the control group, significant changes occurred in only two processes of change, and no change occurred in self-efficacy, physical activity, or cardiorespiratory fitness at 24 or 48 weeks. CONCLUSION: A theory-based intervention is more likely to change the way obese women think and behave in relation to physical activity than a traditional exercise program that does not incorporate behavior change theory.

Adult↗
PubMedDate not supplied

Evaluation of a social marketing campaign targeting preschool children.

OBJECTIVES: To determine the effectiveness of a pilot social marketing program to increase preschoolers' willingness to try new foods. METHODS: Four Head Start centers participated (2 experimental, 2 control) in a study using a quasi-experimental design. Experimental sites received a 12-week intervention developed using social marketing techniques. The program was evaluated via preference assessments, classroom observations, and teacher surveys. RESULTS: Increased preference for and willingness to try new foods were observed in children from the experimental sites (P<0.05). The program was positively received by Head Start staff. CONCLUSIONS: A social marketing campaign is an effective method to reduce children's neophobia.

Child, Preschool↗