Biomedical subjects
Publications and source records attributed to Jennifer Towne.
Many hospital execs take it on faith that investing in information technology provides value to their hospitals. But experts say there are concrete ways to measure ROI for IT. This gatefold shows how to do it and provides insights from three health care organizations.
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To maintain their viability, hospitals are being compelled to invest in big capital projects such as information technology and renovation and construction. This gatefold examines the trends in credit and capital, and how they affect hospitals' access to money.
The Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily is important in differentially recognizing pathogen products and eliciting appropriate immune responses. These receptors alter gene expression, mainly through the activation of nuclear factor-kappaB and activating protein 1. SIGIRR (single immunoglobulin IL-1R-related molecule), a member of this family that does not activate these factors, instead negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge. Cells from SIGIRR-deficient mice showed enhanced activation in response to either IL-1 or certain Toll ligands. Finally, biochemical analysis indicated that SIGIRR binds to the TLR-IL-1R signaling components in a ligand-dependent way. Our data show that SIGIRR functions as a biologically important modulator of TLR-IL-1R signaling.
Predictions of the rise of a take-charge health care consumer have proved premature. Opinion polls and data paint a confusing portrait of a consumer who wants quality care at discount prices, but who doesn't know how the system works, what it costs or what his or her role is. When will this super consumer emerge, and will the industry change as a result?
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Controlling costs is not the only catalyst for the increase in outsourcing by hospitals. The 13th annual survey shows that in some areas, outsourcing can affect patient satisfaction.
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