Biomedical subjects

Jeong Soon Lee

Publications and source records attributed to Jeong Soon Lee.

5 recordsLinked to original sources

PubMed2006

[Effects of a tilting training program on lower extremities function, depression, and self-efficacy among stroke inpatients].

PURPOSE: The purpose of this study was to identify effects of a tilting training program on lower extremities function, depression, and self-efficacy among stroke inpatients. METHOD: The subjects were 60 stroke patients hospitalized in an oriental medical hospital; 31 in the experimental group and 29 in the control group. A nonequivalent control group pretest-posttest design was used. The tilting training program consisted of 3 sessions and was implemented for 30 minutes daily during 3 weeks. Data was collected from Feb to July 2003, and analyzed by percentage, Fisher's exact probability, chi2-test, and t-test using the SPSS/Win 10.0 computerized program. RESULT: After treatment with the tilting training program, the experimental group was significantly increased in the mean score for function of lower extremities (t=2.72, p=.009) compared to the control group, especially for keeping standing balance (t=2.78, p=.007) and standing by oneself (t=3.32, p=.002). However, in the mean scores of depression and self-efficacy, there were no significant differences between the two groups. CONCLUSION: The tilting training program was effective for increasing the function of lower extremities and to improve walking ability earlier among stroke inpatients. Therefore, the tilting training program is applicable to increase the balance level in standing and walking ability at the early rehabilitation stage for stroke patients.

Adult↗

PubMed2005

Simultaneous measurements of atmospheric pollutants and visibility with a Long-Path DOAS system in urban areas.

In this paper, the applicability of a Long-Path Differential Optical Absorption Spectroscopy (LP-DOAS) system was checked for the feasibility of the simultaneous measurement of trace gases (such as 03, NO2, SO2, and HCHO) and atmospheric visibility (light extinction by aerosols) in Asian urban areas. Field studies show that an LP-DOAS system can simultaneously measure the key pollutants (such as O3, NO2, SO2, and HCHO) at detection limits in the ppb/sub-ppb range as well as the Mie extinction coefficient with an uncertainty of approximately 0.1 km(-1) at time resolution of a few minutes. It is thus concluded that the use of LP-DOAS system is feasible for simultaneous measurement of gaseous pollutants as well as an atmospheric extinction coefficient which is tightly bound to fine particulate concentration.

Aerosols↗

PubMed2004

Polyozellin isolated from Polyozellus multiplex induces phase 2 enzymes in mouse hepatoma cells and differentiation in human myeloid leukaemic cell lines.

Induction of cellular phase 2 detoxifying enzymes is associated with cancer preventive potential. Quinone reductase (QR) has been used as a prototype for anticarcinogenic phase 2 enzymes because of its widespread distribution in mammalian systems, large amplitude of inducer response, and ease of measurement in murine hepatoma cells. Methanol extract of Polyozellus multiplex, which shows a strong QR induction potential, was subjected to bioassay-guided fractionation, and polyozellin (PM1) appeared to be a major active component. In in vitro cultured cells (hepa1c1c7 and BPRc1 cells), polyozellin enhanced QR, glutathione S-transferase (GST) activities, and glutathione (GSH) content in a dose-dependent manner. The compound also significantly promoted differentiation of HL-60 human promyelocytic emia cells. In conclusion, polyozellin deserves further in vivo study to evaluate its potential as a cancer preventive agent.

Agaricales↗

PubMed2003

Anticarcinogenic properties of a daidzein-rich fraction isolated from soybean.

In a previous study, we demonstrated that the methanol extract of soybean powder contains an active component(s) that promotes the differentiation of HL-60 cells. Partial purification of the extract, using solvent fractionation and silica gel chromatography, produced an active fraction rich in daidzein. The daidzein-rich fraction (DRF) was evaluated for its cancer preventive potential by assessing its cytotoxic activity and effect on the expression of the transforming growth factor beta (TGF-beta) family of cytokines and their receptors. DRF appeared to exert cytotoxic activity via an apoptotic pathway as evaluated by a DNA fragmentation assay and caspase-3 induction. DRF also increased the expression of TGF-beta2, but had little effect on the expression of other members of the TGF-beta family of cytokines and their receptors, or on the expression of the vascular endothelial growth factor gene. In conclusion, the DRF isolated from the methanol extract of soybean may have the potential to prevent tumorigenesis and, therefore, deserves to undergo further evaluation of its active component(s) and in vivo evaluation for anticarcinogenic efficacy.

Animals↗

PubMed2003

Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.

In the process of screening for pancreatic lipase inhibitors, which could be used as an anti-obesity measure, the methanol extract of Dioscorea nipponica Makino powder (DP) appeared to have potent inhibitory activity against porcine pancreatic lipase with an IC50 value of 5-10 microg/ml, where the enzyme activity was assayed by using 4-methylumbelliferyl oleate as a substrate. Further purification of active components present in the herb generated dioscin that belongs to the saponin family. Dioscin and its aglycone, diosgenin, both suppressed the time-dependent increase of blood triacylglycerol level when orally injected with corn oil to mice, suggesting their inhibitory potential against fat absorption. Sprague-Dawley rats fed on a high-fat diet containing 5% Dioscorea nipponica Makino and 40% beef tallow gained significantly less body weight and adipose tissue than control animals fed on a high-fat diet alone during an 8-week experimental period (P<0.05).

Adipose Tissue↗