Biomedical subjects

Jerry G Blaivas

Publications and source records attributed to Jerry G Blaivas.

40 records · Page 3Linked to original sources

PubMed2002

Nocturnal polyuria versus overactive bladder in nocturia.

The purpose of this article is to review the current state of knowledge on contributions of nocturnal urine overproduction and overactive bladder to the syndrome of nocturia. We review the recent literature and current state of the art in differential diagnosis, pathophysiology, and classification of nocturia. We found that multiple pathologic factors may result in nocturia, including cardiovascular disease, diabetes mellitus or insipidus, third spacing of fluid, sleep apnea, lower urinary tract obstruction, primary sleep disorders, and behavioral and environmental factors. Thus, nocturia may be attributed to nocturnal polyuria (nocturnal urine overproduction), diminished nocturnal bladder capacity, or both. Distinction between these conditions is made by a simple arithmetic analysis of the 24-hour voiding diary. Understanding the manifold origins of nocturia will lead to rational treatment of specific contributing pathophysiologic factors.

Aged↗

PubMed2002

Role of cystometry in evaluating patients with overactive bladder.

Overactive bladder (OAB) can be caused by a variety of conditions. We believe that cystometrography (CMG) is an essential part of the diagnostic evaluation, both in defining underlying pathophysiology and directing treatment. Essential to the diagnosis of OAB syndrome is some combination of urinary frequency, urgency, urge incontinence, and pain. CMG can be thought of simply as a provocative test to determine whether bladder filling, involuntary detrusor contractions, or low bladder compliance in fact reproduces any of these symptoms, and whether the symptoms abate when the bladder is empty or when the pressure decreases. At another level, the CMG has been likened to "the reflex hammer" of the lower urinary tract and, as such, provides important neurologic information. Finally, the voiding phase of the CMG is an essential component of the detrusor pressure/uroflow study, which is the only accurate method of diagnosing urethral obstruction and impaired detrusor contractility. Both of these conditions can coexist with detrusor overactivity. The treatment of OAB depends on the underlying cause. We believe that only by understanding the particular cystometric characteristics of patients with OAB can we determine the appropriate treatment. Urodynamic testing should serve as an essential part of therapy and guide future research in diagnosis and management.

Aged↗

PubMed2002

Evaluating incontinence in women.

Urinary incontinence in women has a multitude of presentations and can be a pure and simple entity or a complicated combination of overlying disorders. The diagnosis and work-up of the incontinent woman should proceed from the classic tools of medical treatment, as well as the history and physical exam, and should incorporate modern techniques of dynamic imaging. It is vital to remember that it is often not until a simple treatment has failed that we appreciate a patient's complex problem, and, for this reason, we advocate appropriate use of the available technologies in order to separate more carefully the straightforward disorder from the intricate and convoluted problems. A thorough investigation of the multiple dimensions of urinary incontinence in the female patient, using subjective and objective testing, is the key to diagnostic and clinical success.

Adult↗

PubMed2002

Non-neurogenic female voiding dysfunction.

PURPOSE OF REVIEW: The pathophysiological mechanisms of female voiding phase dysfunction are poorly understood, and there are neither standard definitions nor guidelines for diagnosis and treatment. The aim of this review is to present up-to-date data and controversies associated with non-neurogenic female voiding dysfunction. RECENT FINDINGS: Conceptually, voiding phase dysfunction may have bladder or urethral causes. Bladder causes include detrusor contraction of inadequate magnitude or duration to effect bladder emptying (detrusor underactivity), or the absence of detrusor contraction (detrusor arreflexia). Urethral causes consist of bladder outlet obstruction as a result of urethral overactivity (functional obstruction), or anatomical (mechanical obstruction) pathologies. The specific prevalence and contribution of each of the above mechanisms is unknown. Furthermore, a correct and timely diagnosis may be difficult, because clinical features are very similar to those of other lower urinary tract symptoms, and diagnostic modalities are often inconclusive or even misleading. A full urodynamic evaluation is essential in making the diagnosis; however, standard urodynamic definitions are still lacking. In the following review, we will present recent findings associated with the prevalence, etiology and diagnosis of each of the different categories of female voiding phase dysfunction, and highlight new advances presented during the past year. SUMMARY: Further epidemiological and pathophysiological investigations are needed to evaluate the causes and main risk factors of voiding dysfunction in women. A better understanding of the pathophysiological mechanisms associated with this challenging condition may provide the possibility to use appropriate diagnostic and treatment modalities, thus avoiding unnecessary interventions.

Female↗