Biomedical subjects

Jerzy Gil

Publications and source records attributed to Jerzy Gil.

14 recordsLinked to original sources

PubMed2004

[Inflammatory bowel diseases--pathogenesis and clinical symptoms].

The common factor of inflammatory bowel diseases is the unknown etiologic agent. It's suggested that it could be genetic predisposition, environment and immunologic factor. It seems probable that the etiology of these diseases has many sources but the pathogenesis is similar. Inflammatory bowel diseases etiology requires more research but the immunological system disturbances are out of the question. The most typical course of these diseases is the one with remissions and relapses. Clinical symptoms vary and depend on localization, phase and presence of complications. In this paper we present some basic information about epidemiology, pathogenesis and the clinical course of inflammatory bowel diseases.

Humans↗

PubMed2004

[Inflammatory bowel diseases--imaging diagnostics].

The basic diagnostic procedure in ulcerative colitis is an endoscopy of gastrointestinal tract. It allows the macroscopic evaluation as well as the specimen taking for histological assessment what is the basis for ultimate diagnosis. In case of Crohn's disease the radiological diagnostics is of equal importance as endoscope evaluation. The imaging of inflammatory changes in Crohn's disease still poses some difficulties, especially, that located in the small intestine. Lately, the range of accessible examinations has been wider. We have in disposal the ultrasonography, the computed tomography, the magnetic resonance imaging and the capsular endoscopy. All of them are of great use in the diagnosis of Crohn's disease. In case of microscopic colitis all the imaging diagnostics has no use. The only one mean to establish the diagnosis is a histological assessment. What is more, in the period of remission the colon tissue could be normal. In this paper we discussed the traditional and contemporary intestine imaging methods in inflammatory bowel diseases. The conclusion is that the further progress in science offers a better imaging and, what is even more important, the more efficient diagnostics and treatment of these diseases.

Humans↗

PubMed2004

[Histoclinic of nonspecific inflammatory bowel diseases].

In the paper pathomorphological indices of changes in inflammatory bowel lesions were presented. Additionally a clinicopathological correlation has been performed. The necessity of collaboration between gastroenterologist and pathomorphologist in diagnostic process of inflammatory bowel lesions has been indicated. The collaboration should mainly result from the lack of repeated morphological changes in most cases of inflammatory bowel lesions, but also from lack of specificity of signs and symptoms in these inflammations.

Humans↗

PubMed2004

[The conservative treatment of nonspecific inflammatory bowel diseases].

The treatment of inflammatory bowel diseases includes the nutritional management, the pharmacotherapy and the surgical treatment. The main aim of treatment is to achieve the remission, to prevent a relapse and to take a decision of surgical treatment. The treatment is introduced in the relevance to the intensification of disease. To assess properly the level of the intensification of disease there is a need of deep knowledge of clinical manifestations of the disease. In the treatment the corticosteroids, 5-aminosalicylic acid (5-ASA) or immunosuppressive treatment are used. Immunosuppressive treatment is now a widely accepted standard in Crohn's disease treatment. Some cases of Crohn's disease could be treated with anti-TNFalpha antibodies that successfully treat the relapses of disease. This treatment is especially well suited to cases that are not successfully treated with the standard pharmacological treatment. The nonsurgical treatment is successful in most cases. There are no standards of treatment of microscopic colitis. We usually start the treatment with 5-ASA and an antidiarrheal agent. In case of failure of this treatment we introduce corticosteroids. In this paper authors present basic information about the current state of knowledge about inflammatory bowel diseases treatment.

Anti-Inflammatory Agents↗

PubMed2004

[Possibilities and limitations of morphological diagnosis in early stages of colitis].

In the paper the most frequent difficulties in diagnosis of early stages of colitis has been presented. Also the most frequent sources of errors depending on methods of obtaining and fixing of material as well as diagnostic possibilities of various kinds of obtained biopsy material has been shown. The role of close cooperation between clinician and pathologist in the earliest stages of diagnostic efforts and final diagnosis has been emphasized.

Biopsy↗

PubMed2004

[Ischaemic intestinal disease--still opened diagnostic clinical and pathomorphological problem].

Contemporary opinions on etiology and pathogenesis of ischaemic colitis have been presented. Diagnostic difficulties in endoscopic and pathologic examination of colonic ischaemic changes have also been discussed. Some aspects of differential diagnosis of ischaemic colitis has been discussed. The literature opinions and authors own experience indicate that ischaemic colitis is still serious histoclinical problem which could be resolved only if close cooperation of gastrologists and pathologists has been applied.

Algorithms↗

PubMed2004

[Irritable bowel syndrome--pathogenesis, management].

Irritable bowel syndrome creates many diagnostic and treatment difficulties in a general practitioner practice as well as in a specialist practice. Etiopathogenesis of this illness still elicit some controversy. In a diagnostic process, apart from an organic basis excluding, the most important is a medical history of a patient because of the fact that a right symptoms interpretation usually allows a correct diagnosis establishment. A treatment is in its premise a symptomatic treatment, is long-lasting and based on a mutual trust between a doctor and a patient. Basic information concerning this illness is presented in this article.

Antidepressive Agents↗

PubMed2004

[Antireflux endoscopic procedures].

In recent few years there took place a significant development of endoscopic antireflux procedures. There appeared a need for review of these procedures. There could be distinguished three basic directions in treatment; endoscopic sewing, injection and implantation technique based on administering polymer-based, biologically neutral substances and the technique based on applying radiation of radiowave length in the region of lower esophageal sphincter.

Endoscopy↗

PubMed2004

[The contemporary endoscopic methods of treatment of gastroesophageal reflux disease complications].

Gastroesophageal reflux disease (GERD) is one of the most common publication subjects in gastroenterology field for more than twenty years. The following article is a review of endoscopic methods of treatment of GERD complications. It is interesting that complications of disease are quite common despite the constant development of diagnostics and treatment methods. It is still common to diagnose the disease when the first manifestation is the esophagus constriction. The complication of GERD is the intestinal metaplasia and adenocarcinoma of the distal part of the esophagus. There are effective endoscopic methods of GERD complications treatment. The most effective are esophagus dilations and endoscopic pathological mucosae layer removal like photodynamic therapy, laser ablation, argon coagulation, multipolar coagulation or mucosectomy.

Endoscopy↗

PubMed2004

[Complications of endoscopic procedures].

Endoscopic procedures became the widely accepted standard diagnostic tool used in diagnostics and treatment of gastrointestinal tract diseases. There are complications associated these procedures are quite rare but can be very serious and even life-threatening. The following paper presents the current knowledge about the prevalence, risk factors and the character of these complications. We should distinguish complications connected with the upper GI endoscopy, complications of colonoscopy and complications connected with endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincteropapillotomy (ES) procedures.

Cholangiopancreatography, Endoscopic Retrograde↗

PubMed2004

[Assessment of duodenogastric reflux 24h variability in subjects with functional dyspepsia].

Symptoms of functional dyspepsia demonstrate significant variability, among others dependently on the time of the day and on consumed meals. The aim of the study was to find out whether duodenogastric reflux is observed in subjects with nonulcer (NUD) and dysmotor dyspepsia (DD) and whether its intensification changes within 24 h. Investigations comprised 25 subjects with NUD and 25 with DD, aged 19-43 years after exclusion of other diseases and H. pylori infection. The gastric content of bilirubin was registered with Bilitec 2000 Synectics Medical. Duodenogastric reflux episodes were observed in both groups but their intensification and 24h dynamics were differentiated. In subjects with DD total reflux index was significantly higher than in those with NUD (mean=18.0+/-9.5% and mean=6.3+/-4.1%; p<0.05). These differences were particularly visible in after meal (mean=21.2+/-7.9% and mean=10.4+/-6.6%; p<0.01) and night time (mean=8.7+/-3.6% and mean=2.9+/-0.9%; p<0.01). The results of the study indicate that bilimetry may be useful in differentiation of the form of dyspepsia and in selection of rational therapy.

Adult↗

PubMed2004

[Peptic ulcer disease etiology, diagnosis and treatment].

Authors in this article present etiology, clinical manifestations, diagnostic procedures and treatment of peptic ulcer disease in children and adults. Increased gastric acid output, Helicobacter pylori, NSAIDs and stress are the basic risk factors in peptic ulcer disease. H. pylori infection is a widely known risk factor in peptic ulcer disease and influences diagnostic and treatment procedures. Primary ulcer disease concerns mainly duodenum and is accompanied by H. pylori infection. Gastroscopy and Helicobacter tests are the only reliable procedures to diagnose peptic ulcer disease. Nowadays the most important aim in peptic ulcer treatment is the H. pylori eradication. Therapy with two antibiotics and a protein pomp inhibitor eradicates the bacteria, treats the ulceration and lowers the number of ulcer recurrence. In non-infected H. pylori ulcers or in a long-term treatment protein pomp inhibitors and H2-inhibitors are effective as well in gastroprotective therapy.

Adult↗

PubMed2004

[Complication of NSAIDs treatment in gastrointestinal tract].

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the common medicaments administered to relieve pain and other inflammation symptoms. Apart from indisputable advantages, the use of these can cause the undesired complications especially concerning gastrointestinal tract. Some of them could be serious. The most disturbing is that some of the gastrointestinal tract damage done by NSAIDs is asymptomatic. It is imperative to identify risk factors in patients who use NASIDs and to undertake the appropriate preventive measures. Nowadays it is possible to implement prophylaxis and to avoid complications and to improve the safety profile. In this paper authors presented conditions under which the complications of use of NSAIDs could appear and the possible prophylactic measures that could be undertaken. The most common is the use of proton pump inhibitor.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMed2004

[The influence of Helicobacter pylori eradication on oesophageal pH-metry and bilimetry results in patients with nonulcer dyspepsia].

Substernal, fasting and night pains with no endoscopic findings in the upper gastrointestinal tract are the leading symptoms of nonulcer dyspepsia (NUD). Our study aimed at determining whether there is duodenogastroesophageal reflux in patients with NUD and to evaluate what role Helicobacter pylori plays in NUD pathophysiology. The study comprised 40 patients, in whom endoscopy, breath test (UBT-13C), 24-hour pH-metry (Digitrapper III) and bilimetry (Bilitec 2000) of the esophagus were performed before and after 7-day antibacterial treatment (pantoprazole 2 x 40 mg, amoxicillin 2 x 1000 mg, clarithromycin 2 x 500 mg). Eradication was achieved in 29 patients, in whom total index of acid reflux (t% pH < 4.0) decreased from 23.1+/-10.4% to 13.1+/-6.2% (p<0.05) and alkaline reflux index (t% abs > 0.14) from 12.9+/-6.3 to 8.1+/-5.7% (p>0.05). Positive correlations between urea breath test results and the indexes of acid (r=0.692) and alkaline refluxes (r=0.246) were observed. In patients with nonulcer dyspepsia infected with Helicobacter pylori complex functional disorders are present. They are expressed as duodenogastroesophageal reflux. The refluxes intensity depends on the extent of Helicobacter pylori infection, which should be remembered when planning antibacterial treatment.

Adult↗