Biomedical subjects

Jerzy Kopeć

Publications and source records attributed to Jerzy Kopeć.

4 recordsLinked to original sources

PubMed2006

[Diagnostic and therapeutic aspects of dialysis-related amyloidosis].

The definitive diagnosis of dialysis-related amyloidosis based on histologic findings suffers from invasive surgical procedure and punctual information. Imaging techniques: ultrasonography, X-ray, computed tomography or magnetic resonance are relatively nonspecific and not sensitive enough. Scintigraphy using radio-labelled beta-2-microglobulin currently represents the most specific method to noninvasively diagnosis dialysis-related amyloidosis. Available therapeutic methods include the removal of BMG and palliation of symptoms. Hemodialysis high-flux and hemodiafiltration based on convection are more effective in elimination of BMG than standard hemodialysis with diffusive transport as a dominant mechanism. Use of the adsorption columns Lixelle reduces plasma BMG concentration and leads to clinical improvement of DRA. Medical therapy consists of the use of low dose corticosteroids and non-steroidal anti-inflammatory drugs. Surgical therapy is often necessary in the late stages of DRA. Renal transplantation is still the optimal method of DRA treatment.

Adsorption↗

PubMed2005

[Factors predisposing to malnutrition development in the patients on maintenance hemodialysis].

Malnutrition of maintenance hemodialysis patients is a serious clinical problem, strongly and negatively affecting their outcome. However, very few studies are available concerning assessment of nutritional state and its predisposing factors in the Polish hemodialysed patient population. Included were 103 patients: 49 man and 54 woman (aged 48.57 years), on maintenance hemodialysis for an average of 71.46 +/- 64.3 months. They were subjected to anthropometry, SGA scale and biochemical evaluation. Simultaneously we calculated dialysis adequacy indicators. Then we compared obtained results with anthropometrical and biochemical norms and results obtained from the group of 29 healthy volunteers. Hemodialysed patients have been significantly underweight (62.51 vs. 73.55 kg in controls). Muscle mass loss dominated: AMA/50 centile AMA in the patients vs. controls have been 75.75 vs. 99.3%. Analysing body weight after dialysis to standard body weight (obtained from anthropometric data) ratio of 5.8% of patients were severely malnourished, 60.2% moderately malnourished. Analysing the patient study group 8.4% had albumin < 35 g/l and 33.3% prealbumin < 0.3 g/l. Only 34% achieved 10-12 points in the SGA scale. Normalized pcr < 1.2 g/kg/day was obtained in 54.4% patients. In the elderly we observed malnutrition more frequently than in the younger population. When pcr increases, also LBM and albumin level in blood increases. The patients who had metabolic acidosis revealed higher pcr and lower albumin. We did not find any relationship between Kt/V and AMA, LBM or albumin. The patients, who were underdialysed revealed lower prealbumin levels.

Adult↗

PubMed2003

[Carbonyl stress significance in the pathogenesis of dialysis-related amyloidosis].

Advanced glycation end products play a causal role in the pathogenesis of diabetic complications. Increased concentration of advanced glycation and lipooxidation end products in uremia are independent of hyperglycemia and decreased glomerular filtration rate. Increased carbonyl stress in chronic renal failure leads to nonenzymatic protein modification. Beta-2-microglobulin modified with carbonyl stress induces cell reaction, which may initiate dialysis arthropathy.

Amyloidosis↗

PubMedDate not supplied

[The "Functional -QEMG" method -- a substantial progress in electromyography (EMG)].

In contradistinction to the traditional quantitative EMG, our new "Functional-QEMG" method provides new information about structural and functional changes in the whole population of active motor units (MUs) in various neuromuscular disorders. Individual motor unit action potentials (MUAPs) and the interference pattern (IP) recordings are analyzed not as complementary measurements but as one integral test. Such a complex of EMG signals is submitted to a non-linear dynamic analysis determining interrelationships between an active MU size and its functional properties. Structural changes in MU size represent the primary destructive process, while the resulting changes in MU functional properties due to a compensatory mechanism (a secondary restorative process) provide new and very useful diagnostic information. All EMG data are processed online and automatically classified by a special computer-assisted diagnostic program as either a normal or pathological (myogenic or neurogenic) EMG recording. At the same time severity of muscle damage is assessed. This article illustrates how both the efficacy and limitations of compensatory mechanisms are related to structural damage in various neuromuscular disorders. The "Functional-QEMG" method application in clinical practice for over ten years has evidenced that this new approach is a turning point in improving the EMG diagnosis. This automatic method provides online reliable answers to most of the questions facing an electromyographer in daily routine investigations.

Adolescent↗